Stub

Regimens that have not proven to be superior to a standard-of-care comparison and are thus unlikely to be expanded upon unless new evidence comes forward. This page is primarily to drive the HemOnc Ontology and for historic interest.

Last updated on 2024-07-23: 410 regimens on this page 410 variants on this page

Regimens

3M

3M: Mitomycin, Mitoxantrone, Methotrexate

Regimen

Chemotherapy

• Mitomycin (Mutamycin)
• Mitoxantrone (Novantrone)
• Methotrexate (MTX)

4d+7

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

4i+7

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Idarubicin (Idamycin)

5-FU & RT

Regimen

Chemotherapy

• Fluorouracil (5-FU)

Radiotherapy

• Concurrent radiation therapy

5-FU, Cyclophosphamide, Dactinomycin

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Dactinomycin (Cosmegen)
• Fluorouracil (5-FU)

7+2d

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

7+3a

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Doxorubicin (Adriamycin)

7+3d & Azacitidine

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)
• Azacitidine (Vidaza)

7+3d & GM-CSF

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

Growth factor therapy

• Sargramostim (Leukine)

7+3d & Zosuquidar

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

7+3i & Clofarabine

7+3i & Clofarabine: 7 days of cytarabine, 3 days of idarubicin, Clofarabine

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Idarubicin (Idamycin)
• Clofarabine (Clolar)

7+3i & Lenalidomide

7+3i & Lenalidomide: 7 days of cytarabine, 3 days of idarubicin, Lenalidomide

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Idarubicin (Idamycin)

Targeted therapy

• Lenalidomide (Revlimid)

7+4d

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

7+4i

7+4i: 7 days of cytarabine, 4 days of idarubicin

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Idarubicin (Idamycin)

7+5d

7+5d: 7 days of cytarabine, 5 days of daunorubicin

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

7+5i & Quinine

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Idarubicin (Idamycin)
• Quinine (Qualaquin)

10+3d

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

A-C

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)

A-CHOP-14

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)
• Vincristine (Oncovin)

Glucocorticoid therapy

• Prednisone (Sterapred)

Targeted therapy

• Alemtuzumab (Campath)

A-D-CMF

Regimen

Chemotherapy

• Docetaxel (Taxotere)
• Doxorubicin (Adriamycin)
• Cyclophosphamide (Cytoxan)
• Methotrexate (MTX)
• Fluorouracil (5-FU)

A-D

Regimen

Chemotherapy

• Docetaxel (Taxotere)
• Doxorubicin (Adriamycin)

A-ICE

A-ICE: ATRA, Idarubicin, Cytarabine, Etoposide

Regimen

Targeted therapy

• All-trans retinoic acid (ATRA)

Chemotherapy

• Cytarabine (Ara-C)
• Mitoxantrone (Novantrone)
• Etoposide (Vepesid)

Abiraterone & Enzalutamide

Regimen

Endocrine therapy

• Abiraterone (Zytiga)
• Enzalutamide (Xtandi)

Abiraterone & Ipatasertib

Regimen

Endocrine therapy

• Abiraterone (Zytiga)

Targeted therapy

• Ipatasertib (GDC-0068)

Abiraterone, Radium-223, Prednisone

Regimen

Endocrine therapy

• Abiraterone (Zytiga)
• Prednisone (Sterapred)

Radiotherapy

• Radium-223 (Xofigo)

ABV

ABV: Adriamycin (Doxorubicin), Bleomycin, Vinblastine

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Bleomycin (Blenoxane)
• Vinblastine (Velban)

ABVP

ABVP: Adriamycin (Doxorubicin), Bleomycin, Vinblastine, Platinol (Cisplatin)

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Bleomycin (Blenoxane)
• Vinblastine (Velban)
• Cisplatin (Platinol)

AC-KP

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)

Targeted therapy

• Pertuzumab (Perjeta)

Antibody-drug conjugate therapy

• Trastuzumab emtansine (Kadcyla)

Acalabrutinib & Venetoclax

Regimen

Targeted therapy

• Acalabrutinib (Calquence)
• Venetoclax (Venclexta)

ACP

ACP: Atezolizumab, Carboplatin, Paclitaxel

Regimen

Immunotherapy

• Atezolizumab (Tecentriq)

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

AD-CMF

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Docetaxel (Taxotere)
• Cyclophosphamide (Cytoxan)
• Methotrexate (MTX)
• Fluorouracil (5-FU)

Adavosertib & Gemcitabine

Regimen

Targeted therapy

• Adavosertib (MK-1775)

Chemotherapy

• Gemcitabine (Gemzar)

Afatinib & Vinorelbine

Regimen

Chemotherapy

• Vinorelbine (Navelbine)

Targeted therapy

• Afatinib (Gilotrif)

Alisertib monotherapy

Regimen

Targeted therapy

• Alisertib (MLN-8237)

Altretamine & Melphalan

Regimen

Chemotherapy

• Altretamine (Hexalen)
• Melphalan (Alkeran)

AME

AME: Ara-C (Cytarabine), Mitoxantrone, Etoposide

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Mitoxantrone (Novantrone)
• Etoposide (Vepesid)

Amonafide & Cytarabine

Regimen

Chemotherapy

• Amonafide (Quinamed)
• Cytarabine (Ara-C)

Amrubicin & Cisplatin

Regimen

Chemotherapy

• Amrubicin (Calsed)
• Cisplatin (Platinol)

Amsacrine & Cytarabine

Regimen

Chemotherapy

• Amsacrine (Amsidine)
• Cytarabine (Ara-C)

Amsacrine & IDAC

Amsacrine & IDAC: Amsacrine & Intermediate Dose Ara-C (Cytarabine)

Regimen

Chemotherapy

• Amsacrine (Amsidine)
• Cytarabine (Ara-C)

Amsacrine monotherapy

Regimen

Chemotherapy

• Amsacrine (Amsidine)

Anastrozole and Everolimus

Regimen

Endocrine therapy

• Anastrozole (Arimidex)

Targeted therapy

• Everolimus (Afinitor)

Anastrozole and Lapatinib

Regimen

Endocrine therapy

• Anastrozole (Arimidex)

Targeted therapy

• Lapatinib (Tykerb)

Anastrozole and Tamoxifen

Regimen

Endocrine therapy

• Anastrozole (Arimidex)
• Tamoxifen (Nolvadex)

Anlotinib monotherapy

Regimen

Targeted therapy

• Anlotinib (Fukewei)

API

API: Adriamycin (Doxorubicin), Platinol (Cisplatin), Ifosfamide

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Cisplatin (Platinol)
• Ifosfamide (Ifex)

Atezolizumab & RT

Regimen

Immunotherapy

• Atezolizumab (Tecentriq)

Radiotherapy

• External beam radiotherapy

ATRA, Cytarabine, Etoposide

Regimen

Targeted therapy

• All-trans retinoic acid (ATRA)

Chemotherapy

• Cytarabine (Ara-C)
• Etoposide (Vepesid)

AVML

AVML: Ara-C (Cytarabine), Vincristine, Methotrexate, Leucovorin

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Vincristine (Oncovin)
• Methotrexate (MTX)

Supportive therapy

• Leucovorin (Folinic acid)

Axitinb & Toripalimab

Regimen

Immunotherapy

• Toripalimab (Loqtorzi)

Targeted therapy

• Axitinib (Inlyta)

Azacitidine & Eltrombopag

Regimen

Chemotherapy

• Azacitidine (Vidaza)

Growth factor therapy

• Eltrombopag (Promacta)

Azacitidine & Gilteritinib

Regimen

Chemotherapy

• Azacitidine (Vidaza)

Targeted therapy

• Gilteritinib (Xospata)

Barasertib & LoDAC

Regimen

Chemotherapy

• Cytarabine (Ara-C)

Targeted therapy

• Barasertib (AZD-1152)

Binimetinib monotherapy

Regimen

Targeted therapy

• Binimetinib (Mektovi)

Bortezomib & Bevacizumab

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
White et al. 2012 (AMBER)	2007-2009	Randomized Phase 2 (E-esc)	Bortezomib	Did not meet primary endpoint of PFS (HR 0.74, 95% CI 0.43-1.28)

Targeted therapy

• Bortezomib (Velcade)
• Bevacizumab (Avastin)

Bortezomib & Siltuximab

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Orlowski et al. 2015 (CR012784)	2006-2009	Randomized Phase 2 (E-esc)	Bortezomib	Did not meet primary endpoint of PFS (HR 0.87, 95% CI 0.65-1.16)

Targeted therapy

• Bortezomib (Velcade)

Immunosuppressive therapy

• Siltuximab (Sylvant)

BTH (Docetaxel)

BTH: Bevacizumab, Taxotere (Docetaxel), Herceptin (Trastuzumab)

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Bevacizumab (Avastin)
• Trastuzumab (Herceptin)

BTOC

BTOC: BCNU, Thiotepa, Oncovin (Vincristine), Cyclophosphamide

Regimen

Chemotherapy

• Carmustine (BCNU)
• Thiotepa (Thioplex)
• Vincristine (Oncovin)
• Cyclophosphamide (Cytoxan)

Buparlisib & Fulvestrant

Regimen

Targeted therapy

• Buparlisib (BKM-120)

Endocrine therapy

• Fulvestrant (Faslodex)

Buparlisib & Paclitaxel

Regimen

Targeted therapy

• Buparlisib (BKM-120)

Chemotherapy

• Paclitaxel (Taxol)

CAD

CAD: Cyclophosphamide, Adriamycin (Doxorubicin), DDP (Cisplatin)

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)
• Cisplatin (Platinol)

Capecitabine & Cisplatin (CX) & Bevacizumab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Cisplatin (Platinol)

Targeted therapy

• Bevacizumab (Avastin)

Capecitabine & Cisplatin (CX) & Ramucirumab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Cisplatin (Platinol)

Targeted therapy

• Ramucirumab (Cyramza)

Capecitabine & Cisplatin (CX) & Simvastatin

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Cisplatin (Platinol)

Targeted therapy

• Simvastatin (Zocor)

Capecitabine & Cisplatin (CX), Durvalumab, RT

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Cisplatin (Platinol)

Immunotherapy

• Durvalumab (Imfinzi)

Radiotherapy

• External beam radiotherapy

Capecitabine & Docetaxel (TX) & Bevacizumab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Docetaxel (Taxotere)

Targeted therapy

• Bevacizumab (Avastin)

Capecitabine & Paclitaxel (XP)

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Paclitaxel (Taxol)

Capecitabine & Ruxolitinib

Regimen

Chemotherapy

• Capecitabine (Xeloda)

Targeted therapy

• Ruxolitinib (Jakafi)

Capecitabine & Sorafenib

Regimen

Chemotherapy

• Capecitabine (Xeloda)

Targeted therapy

• Sorafenib (Nexavar)

Capecitabine & Sunitinib

Regimen

Chemotherapy

• Capecitabine (Xeloda)

Targeted therapy

• Sunitinib (Sutent)

Capecitabine & Vinflunine

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Vinflunine (Javlor)

Capecitabine & Vinorelbine (NX)

NX: Navelbine (Vinorelbine) & Xeloda (Capecitabine)

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Vinorelbine (Navelbine)

Capecitabine, Cisplatin, Cetuximab, RT

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Cisplatin (Platinol)

Targeted therapy

• Cetuximab (Erbitux)

Radiotherapy

• Concurrent radiation therapy

Capecitabine, Erlotinib, RT

Regimen

Chemotherapy

• Capecitabine (Xeloda)

Targeted therapy

• Erlotinib (Tarceva)

Radiotherapy

• Concurrent radiation therapy

CapeOx & Cediranib

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Oxaliplatin (Eloxatin)

Targeted therapy

• Cediranib (Recentin)

CapeOx & Cetuximab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Oxaliplatin (Eloxatin)

Targeted therapy

• Cetuximab (Erbitux)

CapeOx & Lapatinib

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Oxaliplatin (Eloxatin)

Targeted therapy

• Lapatinib (Tykerb)

CapeOx & RT

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Oxaliplatin (Eloxatin)

Radiotherapy

• External beam radiotherapy

CapeOx & Tislelizumab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Oxaliplatin (Eloxatin)

Immunotherapy

• Tislelizumab (Baizean)

CapeOx, Bevacizumab, Cetuximab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Oxaliplatin (Eloxatin)

Targeted therapy

• Bevacizumab (Avastin)
• Cetuximab (Erbitux)

Capivasertib & Fulvestrant

Regimen

Endocrine therapy

• Fulvestrant (Faslodex)

Targeted therapy

• Capivasertib (Truqap)

CarboMIP

CarboMIP: Carboplatin, Mitomycin, Ifosfamide, Platinol (Cisplatin)

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Mitomycin (Mutamycin)
• Ifosfamide (Ifex)
• Cisplatin (Platinol)

Carboplatin & Docetaxel (DCb) & Bevacizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Docetaxel (Taxotere)

Targeted therapy

• Bevacizumab (Avastin)

Carboplatin & Docetaxel (DCb) & Celecoxib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Docetaxel (Taxotere)
• Celecoxib (Celebrex)

Carboplatin & Docetaxel (DCb) & Cetuximab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Docetaxel (Taxotere)

Targeted therapy

• Cetuximab (Erbitux)

Carboplatin & Docetaxel (DCb) & Farletuzumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Docetaxel (Taxotere)

Targeted therapy

• Farletuzumab (MORAb-003)

Carboplatin & Docetaxel (DCb) & RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Docetaxel (Taxotere)

Radiotherapy

• External beam radiotherapy

Carboplatin & Doxorubicin

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Doxorubicin (Adriamycin)

Carboplatin & Epirubicin

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Epirubicin (Ellence)

Carboplatin & Etoposide (CE) & Adebrelimab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Etoposide (Vepesid)

Targeted therapy

• Adebrelimab (SHR-1316)

Carboplatin & Etoposide (CE) & Ipilimumab

CE & Ipilimumab: Carboplatin, Etoposide, Ipilimumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Etoposide (Vepesid)

Immunotherapy

• Ipilimumab (Yervoy)

Carboplatin & Etoposide (CE) & Pravastatin

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Etoposide (Vepesid)

Targeted therapy

• Pravastatin (Pravachol)

Carboplatin & Etoposide (CE) & Thalidomide

CE & Thalidomide: Carboplatin, Etoposide, Thalidomide

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Etoposide (Vepesid)

Targeted therapy

• Thalidomide (Thalomid)

Carboplatin & Etoposide (CE), then auto HSCT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Etoposide (Vepesid)

Carboplatin & Gemcitabine (GCb) & Celecoxib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

Targeted therapy

• Celecoxib (Celebrex)

Carboplatin & Gemcitabine (GCb) & Gefitinib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

Targeted therapy

• Gefitinib (Iressa)

Carboplatin & Gemcitabine (GCb), Atezolizumab, Bevacizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

Immunotherapy

• Atezolizumab (Tecentriq)

Targeted therapy

• Bevacizumab (Avastin)

Carboplatin & Gemcitabine (GCb)/Erlotinib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

Targeted therapy

• Erlotinib (Tarceva)

Carboplatin & Paclitaxel (CP) & Agatolimod

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Agatolimod (PF-3512676)

Carboplatin & Paclitaxel (CP) & Atezolizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Immunotherapy

• Atezolizumab (Tecentriq)

Carboplatin & Paclitaxel (CP) & Avelumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Immunotherapy

• Avelumab (Bavencio)

Carboplatin & Paclitaxel (CP) & Bexarotene

CP & Bexarotene: Carboplatin, Paclitaxel, Bexarotene

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Bexarotene (Targretin)

Carboplatin & Paclitaxel (CP) & Cediranib

CP & Cediranib: Carboplatin, Paclitaxel, Cediranib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Cediranib (Recentin)

Carboplatin & Paclitaxel (CP) & Celecoxib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Celecoxib (Celebrex)

Carboplatin & Paclitaxel (CP) & Cetuximab

CP & Cetuximab: Carboplatin, Paclitaxel, Cetuximab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Cetuximab (Erbitux)

Carboplatin & Paclitaxel (CP) & Erlotinib

CP & Erlotinib: Carboplatin, Paclitaxel, Erlotinib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Erlotinib (Tarceva)

Carboplatin & Paclitaxel (CP) & Farletuzumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Farletuzumab (MORAb-003)

Carboplatin & Paclitaxel (CP) & Figitumumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Figitumumab (CP-751,871)

Carboplatin & Paclitaxel (CP) & Gefitinib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Gefitinib (Iressa)

Carboplatin & Paclitaxel (CP) & Interferon gamma-1b

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Immunotherapy

• Interferon gamma-1b (Actimmune)

Carboplatin & Paclitaxel (CP) & Motesanib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Motesanib (AMG-706)

Carboplatin & Paclitaxel (CP) & Pegylated liposomal doxorubicin

CP & PLD: Carboplatin, Paclitaxel, Pegylated Liposomal Doxorubicin
TC & PLD: Taxol (Paclitaxel), Carboplatin, Pegylated Liposomal Doxorubicin

Regimen

Chemotherapy

• Paclitaxel (Taxol)
• Carboplatin (Paraplatin)
• Pegylated liposomal doxorubicin (Doxil)

Carboplatin & Paclitaxel (CP) & Rebimastat

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Rebimastat (BMS-275291)

Carboplatin & Paclitaxel (CP) & Sorafenib

CP & Sorafenib: Carboplatin, Paclitaxel, Sorafenib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Sorafenib (Nexavar)

Carboplatin & Paclitaxel (CP) & Tirapazamine

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)
• Tirapazamine (Tirazone)

Carboplatin & Paclitaxel (CP) & Topotecan

TC & Topotecan: Taxol (Paclitaxel), Carboplatin, Topotecan

Regimen

Chemotherapy

• Paclitaxel (Taxol)
• Carboplatin (Paraplatin)
• Topotecan (Hycamtin)

Carboplatin & Paclitaxel (CP) & Trebananib

TC & Trebananib: Taxol (Paclitaxel), Carboplatin, Trebananib

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Vergote et al. 2019 (TRINOVA-3)	2012-2014	Phase 3 (E-esc)	TC	Did not meet primary endpoint of PFS (HR 0.93, 95% CI 0.79-1.09)

Chemotherapy

• Paclitaxel (Taxol)
• Carboplatin (Paraplatin)

Targeted therapy

• Trebananib (AMG-386)

Carboplatin & Paclitaxel (CP) & Vadimezan

CP & Vadimezan: Carboplatin, Paclitaxel, Vadimezan

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Vadimezan (AS-A404)

Carboplatin & Paclitaxel (CP) & Veliparib

CP & Veliparib: Carboplatin, Paclitaxel, Veliparib

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Veliparib (ABT-888)

Carboplatin & Paclitaxel (CP), Atezolizumab, Bevacizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Immunotherapy

• Atezolizumab (Tecentriq)

Targeted therapy

• Bevacizumab (Avastin)

Carboplatin & Paclitaxel (CP), Bevacizumab, Cetuximab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Bevacizumab (Avastin)
• Cetuximab (Erbitux)

Carboplatin & Paclitaxel (CP), Cetuximab, RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Cetuximab (Erbitux)

Radiotherapy

• External beam radiotherapy

Carboplatin & Topotecan

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Topotecan (Hycamtin)

Carboplatin, Docetaxel, RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Docetaxel (Taxotere)

Radiotherapy

• External beam radiotherapy

Carboplatin, Durvalumab, RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)

Immunotherapy

• Durvalumab (Imfinzi)

Radiotherapy

• External beam radiotherapy

Carboplatin, Etoposide, Melphalan

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Etoposide (Vepesid)
• Melphalan (Alkeran)

Carboplatin, Fluorouracil, Bevacizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Fluorouracil (5-FU)

Targeted therapy

• Bevacizumab (Avastin)

Carboplatin, Gemcitabine, Bevacizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

Targeted therapy

• Bevacizumab (Avastin)

Carboplatin, Irinotecan, RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Irinotecan (Camptosar)

Radiotherapy

• External beam radiotherapy

Carboplatin, Lenvatinib, Pemetrexed, Pembrolizumab

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Pemetrexed (Alimta)

Immunotherapy

• Pembrolizumab (Keytruda)

Targeted therapy

• Lenvatinib (Lenvima)

Carboplatin, Paclitaxel, Trastuzumab, RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Paclitaxel (Taxol)

Targeted therapy

• Trastuzumab (Herceptin)

Radiotherapy

• External beam radiotherapy

Carboplatin, Vindesine, RT

Regimen

Chemotherapy

• Carboplatin (Paraplatin)
• Vindesine (Eldisine)

Radiotherapy

• External beam radiotherapy

Carfilzomib & Ibrutinib

Regimen

Targeted therapy

• Carfilzomib (Kyprolis)
• Ibrutinib (Imbruvica)

Carmustine, Cisplatin, RT

Regimen

Chemotherapy

• Carmustine (BCNU)
• Cisplatin (Platinol)

Radiotherapy

• External beam radiotherapy

CAVE & RT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)
• Etoposide (Vepesid)
• Vincristine (Oncovin)

Radiotherapy

• External beam radiotherapy

CBM

CBM: Capecitabine, Bevacizumab, Mitomycin

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Mitomycin (Mutamycin)

Targeted therapy

• Bevacizumab (Avastin)

CCG

CCG: Cisplatin, Carboplatin, Gemcitabine

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

Cediranib monotherapy

Regimen

Targeted therapy

• Cediranib (Recentin)

Chlorambucil, Cisplatin, Doxorubicin

Regimen

Chemotherapy

• Chlorambucil (Leukeran)
• Cisplatin (Platinol)
• Doxorubicin (Adriamycin)

ChlVPP/EVA

ChlVPP/EVA: Chlorambucil, Vinblastine, Procarbazine, Prednisone alternating with Etoposide, Vincristine, Adriamycin (Doxorubicin)

Regimen

Chemotherapy, ChlVPP portion

• Chlorambucil (Leukeran)
• Vinblastine (Velban)
• Procarbazine (Matulane)

Glucocorticoid therapy, ChlVPP portion

• Prednisolone (Millipred)

Chemotherapy, EVA portion

• Etoposide (Vepesid)
• Vincristine (Oncovin)
• Doxorubicin (Adriamycin)

CIB

CIB: Cisplatin, Ifosfamide, Bleomycin

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Ifosfamide (Ifex)
• Bleomycin (Blenoxane)

Cisplatin & Docetaxel (DC) & Bevacizumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Docetaxel (Taxotere)

Targeted therapy

• Bevacizumab (Avastin)

Cisplatin & Docetaxel (DC) & Cetuximab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Docetaxel (Taxotere)

Targeted therapy

• Cetuximab (Erbitux)

Cisplatin & Etoposide (EP) & Paclitaxel

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Etoposide (Vepesid)
• Paclitaxel (Taxol)

Cisplatin & Etoposide (EP) & Pravastatin

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Etoposide (Vepesid)
• Pravastatin (Pravachol)

Cisplatin & Etoposide (EP) & RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Etoposide (Vepesid)

Radiotherapy

• External beam radiotherapy

Cisplatin & Etoposide (EP)/Topotecan monotherapy

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Etoposide (Vepesid)
• Topotecan (Hycamtin)

Cisplatin & Fluorouracil (CF) & Bevacizumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)

Targeted therapy

• Bevacizumab (Avastin)

Cisplatin & Fluorouracil (CF), Durvalumab, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)

Immunotherapy

• Durvalumab (Imfinzi)

Radiotherapy

• External beam radiotherapy

Cisplatin & Fluorouracil (CF), Interferon alfa-2b, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)

Immunotherapy

• Interferon alfa-2b (Intron-A)

Radiotherapy

• External beam radiotherapy

Cisplatin & Fluorouracil (CF), Lenvatinib, Pembrolizumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)

Immunotherapy

• Pembrolizumab (Keytruda)

Targeted therapy

• Lenvatinib (Lenvima)

Cisplatin & Fluorouracil (CF), Pembrolizumab, Trastuzumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)

Immunotherapy

• Pembrolizumab (Keytruda)

Targeted therapy

• Trastuzumab (Herceptin)

Cisplatin & Gemcitabine (GC) & Erlotinib

GC & Erlotinib: Gemcitabine, Cisplatin, Erlotinib

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)

Targeted therapy

• Erlotinib (Tarceva)

Cisplatin & Gemcitabine (GC) & Gefitinib

GC & Gefitinib: Gemcitabine, Cisplatin, Gefitinib

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)

Targeted therapy

• Gefitinib (Iressa)

Cisplatin & Gemcitabine (GC) & Nadroparin

GC & Nadroparin: Gemcitabine, Cisplatin, Nadroparin

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)

Anticoagulation

• Nadroparin (Fraxiparine)

Cisplatin & Gemcitabine (GC) & Sorafenib

GC & Sorafenib: Gemcitabine, Cisplatin, Sorafenib

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)

Targeted therapy

• Sorafenib (Nexavar)

Cisplatin & Gemcitabine (GC) & Tislelizumab

GC & Tislelizumab: Gemcitabine, Cisplatin, Tislelizumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)

Immunotherapy

• Tislelizumab (Baizean)

Cisplatin & Gemcitabine (GC) & Veliparib

GC & Veliparib: Gemcitabine, Cisplatin, Veliparib

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Cisplatin (Platinol)

Targeted therapy

• Veliparib (ABT-888)

Cisplatin & Irinotecan (IC) & Cetuximab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Irinotecan (Camptosar)

Targeted therapy

• Cetuximab (Erbitux)

Cisplatin & Methotrexate

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Methotrexate (MTX)

Cisplatin & Treosulfan

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Treosulfan (Ovastat)

Cisplatin & Vincristine

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Vincristine (Oncovin)

Cisplatin, Avelumab, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)

Immunotherapy

• Avelumab (Bavencio)

Radiotherapy

• Concurrent radiation therapy

Cisplatin, Durvalumab, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)

Immunotherapy

• Durvalumab (Imfinzi)

Radiotherapy

• External beam radiotherapy

Cisplatin, Fluorouracil, Vinblastine, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)
• Vinblastine (Velban)

Radiotherapy

• External beam radiotherapy

Cisplatin, Lapatinib, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)

Targeted therapy

• Lapatinib (Tykerb)

Radiotherapy

• External beam radiotherapy

Cisplatin, Nintedanib, Pemetrexed

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Pemetrexed (Alimta)

Targeted therapy

• Nintedanib (Vargatef)

Cisplatin & Paclitaxel (TP), Cetuximab, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Paclitaxel (Taxol)

Targeted therapy

• Cetuximab (Erbitux)

Radiotherapy

• External beam radiotherapy

Cisplatin & Paclitaxel (TP), Erlotinib, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Paclitaxel (Taxol)

Targeted therapy

• Erlotinib (Tarceva)

Radiotherapy

• External beam radiotherapy

Cisplatin & Paclitaxel (TP), Lenvatinib, Pembrolizumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Paclitaxel (Taxol)

Immunotherapy

• Pembrolizumab (Keytruda)

Targeted therapy

• Lenvatinib (Lenvima)

Cisplatin & Paclitaxel (TP), Tislelizumab, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Paclitaxel (Taxol)

Immunotherapy

• Tislelizumab (Baizean)

Radiotherapy

• External beam radiotherapy

Cisplatin, Pemetrexed, Gefitinib

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Soria et al. 2015 (IMPRESS)	2012-2013	Phase 3 (E-esc)	Cisplatin & Pemetrexed	Did not meet primary endpoint of PFS Median PFS: 5.4 vs 5.4 mo (HR 0.86, 95% CI 0.65-1.13)

Chemotherapy

• Cisplatin (Platinol)
• Pemetrexed (Alimta)

Targeted therapy

• Gefitinib (Iressa)

Cisplatin, Pemetrexed, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Pemetrexed (Alimta)

Radiotherapy

• Concurrent radiation therapy

Cisplatin, Tirapazamine, RT

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Tirapazamine (Tirazone)

Radiotherapy

• External beam radiotherapy

Cisplatin, Vinorelbine, Bevacizumab

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Vinorelbine (Navelbine)

Targeted therapy

• Bevacizumab (Avastin)

CMF & RT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Methotrexate (MTX)
• Fluorouracil (5-FU)

Radiotherapy

• External beam radiotherapy

CODE

CODE: Cisplatin, Oncovin (Vincristine), Doxorubicin, Etoposide

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Vincristine (Oncovin)
• Doxorubicin (Adriamycin)
• Etoposide (Vepesid)

COPPEBVCAD

COPPEBVCAD: Cyclophosphamide, Oncovin (Vincristine), Procarbazine, Prednisone, Epirubicin, Bleomycin, Vinblastine, CCNU (Lomustine), Alkeran (Melphalan), DVA (Vindesine)

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Vincristine (Oncovin)
• Procarbazine (Matulane)
• Epirubicin (Ellence)
• Bleomycin (Blenoxane)
• Vinblastine (Velban)
• Lomustine (CCNU)
• Melphalan (Alkeran)
• Vindesine (Eldisine)

Glucocorticoid therapy

• Prednisone (Sterapred)

Cyclophosphamide & RT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)

Radiotherapy

• External beam radiotherapy

Cyclophosphamide & Thiotepa, then auto HSCT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Thiotepa (Tepadina)
• Thiotepa (Thioplex)

Cyclophosphamide & Thiotepa

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Thiotepa (Tepadina)
• Thiotepa (Thioplex)

Cyclophosphamide & Vincristine (CV)

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Vincristine (Oncovin)

Cyclophosphamide, Dacarbazine, Doxorubicin

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Dacarbazine (DTIC)
• Doxorubicin (Adriamycin)

Cyclophosphamide, Dactinomycin, Fluorouracil

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Dactinomycin (Cosmegen)
• Fluorouracil (5-FU)

Cyclophosphamide, Daunorubicin, Vincristine, Dexamethasone

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Daunorubicin (Cerubidine)
• Vincristine (Oncovin)

Glucocorticoid therapy

• Dexamethasone (Decadron)

Cyclophosphamide, DES, Fluorouracil

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Fluorouracil (5-FU)

Endocrine therapy

• Diethylstilbestrol (DES)

Cyclophosphamide, Etoposide, Lestaurtinib, Methotrexate

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Etoposide (Vepesid)
• Methotrexate (MTX)

Targeted therapy

• Lestaurtinib (CEP-701)

Cyclophosphamide, Etoposide, TBI, then auto HSCT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Etoposide (Vepesid)

Radiotherapy

• External beam radiotherapy

Cyclophosphamide, Mitoxantrone, Thiotepa, then auto HSCT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Mitoxantrone (Novantrone)
• Thiotepa (Tepadina)
• Thiotepa (Thioplex)

Cyclophosphamide, Mitoxantrone, Thiotepa

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Mitoxantrone (Novantrone)
• Thiotepa (Tepadina)
• Thiotepa (Thioplex)

Cytarabine & Ifosfamide

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Ifosfamide (Ifex)

Cytarabine & Imatinib

Regimen

Chemotherapy

• Cytarabine (Ara-C)

Targeted therapy

• Imatinib (Gleevec)

CYVADIC

CYVADIC: CYclophosphamide, Vincristine, ADriamycin (Doxorubicin), Imidazole Carboxamide (Dacarbazine)

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Vincristine (Oncovin)
• Doxorubicin (Adriamycin)
• Dacarbazine (DTIC)

Dacarbazine & Dactinomycin

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Dactinomycin (Cosmegen)

Dacarbazine & Fotemustine

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Fotemustine (Muphoran)

Dacarbazine & Interferon alfa-2b

Regimen

Chemotherapy

• Dacarbazine (DTIC)

Immunotherapy

• Interferon alfa-2b (Intron-A)

Dacarbazine & RT

Regimen

Chemotherapy

• Dacarbazine (DTIC)

Radiotherapy

• External beam radiotherapy

Dacarbazine & Selumetinib

Regimen

Chemotherapy

• Dacarbazine (DTIC)

Targeted therapy

• Selumetinib (Koselugo)

Dacarbazine & Vindesine

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Vindesine (Eldisine)

Dacarbazine, Fluorouracil, Semustine, Vincristine

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Fluorouracil (5-FU)
• Semustine (MeCCNU)
• Vincristine (Oncovin)

Dacarbazine, Fluorouracil, Semustine

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Fluorouracil (5-FU)
• Semustine (MeCCNU)

Dacarbazine, Fotemustine, Interferon alfa-2b

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Fotemustine (Muphoran)

Immunotherapy

• Interferon alfa-2b (Intron-A)

Dacarbazine, Interferon alfa-2b, Tamoxifen

Regimen

Chemotherapy

• Dacarbazine (DTIC)

Endocrine therapy

• Tamoxifen (Nolvadex)

Immunotherapy

• Interferon alfa-2b (Intron-A)

Dactinomycin, Doxorubicin, Vincristine

Regimen

Chemotherapy

• Dactinomycin (Cosmegen)
• Doxorubicin (Adriamycin)
• Vincristine (Oncovin)

DBCT

DBCT: Dacarbazine, BCNU (Carmustine), Cisplatin, Tamoxifen

Regimen

Chemotherapy

• Dacarbazine (DTIC)
• Carmustine (BCNU)
• Cisplatin (Platinol)

Endocrine therapy

• Tamoxifen (Nolvadex)

ddAC-KP

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)

Targeted therapy

• Pertuzumab (Perjeta)

Antibody-drug conjugate therapy

• Trastuzumab emtansine (Kadcyla)

ddEC-KP

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Epirubicin (Ellence)

Targeted therapy

• Pertuzumab (Perjeta)

Antibody-drug conjugate therapy

• Trastuzumab emtansine (Kadcyla)

ddFEC

ddFEC: dose-dense Fluorouracil, Epirubicin, Cyclophosphamide

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Epirubicin (Ellence)
• Cyclophosphamide (Cytoxan)

Supportive therapy

• G-CSF

Dinaciclib monotherapy

Regimen

Targeted therapy

• Dinaciclib (SCH-727965)

Docetaxel & Bavituximab

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Immunotherapy

• Bavituximab (PGN-401)

Docetaxel & Erlotinib

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Erlotinib (Tarceva)

Docetaxel & Fluorouracil

Regimen

Chemotherapy

• Docetaxel (Taxotere)
• Fluorouracil (5-FU)

Docetaxel & Ganetespib

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Ganetespib (STA-9090)

Docetaxel & Gefitinib

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Gefitinib (Iressa)

Docetaxel & Lapatinib (TL)

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Lapatinib (Tykerb)

Docetaxel & Leuprolide

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Endocrine therapy

• Leuprolide (Lupron)

Docetaxel & Pertuzumab

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Pertuzumab (Perjeta)

Docetaxel & Selumetinib

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Selumetinib (Koselugo)

Docetaxel & Sunitinib

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Sunitinib (Sutent)

Docetaxel & Ziv-aflibercept

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Ziv-aflibercept (Zaltrap)

Docetaxel, Lenalidomide, Prednisone

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Endocrine therapy

• Prednisone (Sterapred)

Targeted therapy

• Lenalidomide (Revlimid)

Docetaxel, Prednisone, Bevacizumab

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Endocrine therapy

• Prednisone (Sterapred)

Targeted therapy

• Bevacizumab (Avastin)

Doxorubicin & Etoposide

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Etoposide (Vepesid)

Doxorubicin & Paclitaxel

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Paclitaxel (Taxol)

Doxorubicin & Sorafenib

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)

Targeted therapy

• Sorafenib (Nexavar)

Doxorubicin & Streptozocin

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Streptozocin (Zanosar)

Doxorubicin & Vinblastine (AV)

AV: Adriamycin (Doxorubicin) & Vinblastine

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Vinblastine (Velban)

Doxorubicin & Vinorelbine

Regimen

Chemotherapy

• Doxorubicin (Adriamycin)
• Vinorelbine (Navelbine)

Durvalumab & RT

Regimen

Immunotherapy

• Durvalumab (Imfinzi)

Radiotherapy

• External beam radiotherapy

E-GEMOX

E-GEMOX: Erlotinib, GEMcitabine, OXaliplatin

Regimen

Targeted therapy

• Erlotinib (Tarceva)

Chemotherapy

• Gemcitabine (Gemzar)
• Oxaliplatin (Eloxatin)

EAP

EAP: Etoposide, Adriamycin (Doxorubicin), Platinol (Cisplatin)

Regimen

Chemotherapy

• Etoposide (Vepesid)
• Doxorubicin (Adriamycin)
• Cisplatin (Platinol)

EC-KP

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Epirubicin (Ellence)

Targeted therapy

• Pertuzumab (Perjeta)

Antibody-drug conjugate therapy

• Trastuzumab emtansine (Kadcyla)

EC-TL (Docetaxel)

EC-TL: Epirubicin & Cyclophosphamide, followed by Taxotere (Docetaxel) & Lapatinib
EC-DL: Epirubicin & Cyclophosphamide, followed by Docetaxel & Lapatinib

Regimen

Chemotherapy, EC portion

• Epirubicin (Ellence)
• Cyclophosphamide (Cytoxan)

Chemotherapy, TL portion

• Docetaxel (Taxotere)

Targeted therapy, TL portion

• Lapatinib (Tykerb)

ECVBP

ECVBP: Epirubicin, Cyclophosphamide, Vindesine, Bleomycin, Prednisone

Regimen

Chemotherapy

• Epirubicin (Ellence)
• Cyclophosphamide (Cytoxan)
• Vindesine (Eldisine)
• Bleomycin (Blenoxane)

Glucocorticoid therapy

• Prednisone (Sterapred)

ECX & Bevacizumab

Regimen

Chemotherapy

• Capecitabine (Xeloda)
• Cyclophosphamide (Cytoxan)
• Epirubicin (Ellence)

Targeted therapy

• Bevacizumab (Avastin)

ELF

ELF: Etoposide, Leucovorin, 5-FU (Fluorouracil)

Regimen

Chemotherapy

• Etoposide (Vepesid)
• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)

ELFE

ELFE: Etoposide, Leucovorin, 5-FU (Fluorouracil), Epirubicin

Regimen

Chemotherapy

• Etoposide (Vepesid)
• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)
• Epirubicin (Ellence)

Encorafenib monotherapy

Regimen

Targeted therapy

• Encorafenib (Braftovi)

EP & Ipilimumab

EP & Ipilimumab: Etoposide, Platinol (Cisplatin), Ipilimumab

Regimen

Chemotherapy

• Etoposide (Vepesid)
• Cisplatin (Platinol)

Immunotherapy

• Ipilimumab (Yervoy)

EP, Tamoxifen, RT

EP, Tamoxifen, RT: Etoposide, Platinol (Cisplatin), Tamoxifen, Radiation Therapy

Regimen

Chemotherapy

• Etoposide (Vepesid)
• Cisplatin (Platinol)

Endocrine therapy

• Tamoxifen (Nolvadex)

Radiotherapy

• Concurrent thoracic radiation therapy

Epirubicin & Fluorouracil

Regimen

Chemotherapy

• Epirubicin (Ellence)
• Fluorouracil (5-FU)

Epirubicin & Gemcitabine

Regimen

Chemotherapy

• Epirubicin (Ellence)
• Gemcitabine (Gemzar)

Epirubicin & Mitomycin (EM)

Regimen

Chemotherapy

• Epirubicin (Ellence)
• Mitomycin (Mutamycin)

Epirubicin & Tamoxifen

Regimen

Chemotherapy

• Epirubicin (Ellence)

Endocrine therapy

• Tamoxifen (Nolvadex)

Epirubicin & Vindesine

Regimen

Chemotherapy

• Epirubicin (Ellence)
• Vindesine (Eldisine)

Erlotinib & Figitumumab

Regimen

Targeted therapy

• Erlotinib (Tarceva)
• Figitumumab (CP-751,871)

Erlotinib & Onartuzumab

Regimen

Targeted therapy

• Erlotinib (Tarceva)
• Onartuzumab (MetMAb)

Erlotinib & Sorafenib

Regimen

Targeted therapy

• Erlotinib (Tarceva)
• Sorafenib (Nexavar)

Erlotinib & Sunitinib

Regimen

Targeted therapy

• Erlotinib (Tarceva)
• Sunitinib (Sutent)

Erlotinib & Tivantinib

Regimen

Targeted therapy

• Erlotinib (Tarceva)
• Tivantinib (ARQ-197)

Erlotinib, Bevacizumab, Panitumumab

Regimen

Targeted therapy

• Erlotinib (Tarceva)
• Bevacizumab (Avastin)
• Panitumumab (Vectibix)

Erlotinib, Gemcitabine, Bevacizumab

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Erlotinib (Tarceva)
• Bevacizumab (Avastin)

Everolimus & Letrozole

Regimen

Endocrine therapy

• Letrozole (Femara)

Targeted therapy

• Everolimus (Afinitor)

Everolimus & Paclitaxel

Regimen

Chemotherapy

• Paclitaxel (Taxol)

Targeted therapy

• Everolimus (Afinitor)

Everolimus & Sorafenib

Regimen

Targeted therapy

• Everolimus (Afinitor)
• Sorafenib (Nexavar)

Everolimus & Vinorelbine

Regimen

Chemotherapy

• Vinorelbine (Navelbine)

Targeted therapy

• Everolimus (Afinitor)

Everolimus & Vorolanib

Regimen

Targeted therapy

• Everolimus (Afinitor)
• Vorolanib (CM-082)

Exemestane & Lapatinib

Regimen

Endocrine therapy

• Exemestane (Aromasin)

Targeted therapy

• Lapatinib (Tykerb)

Exemestane & Palbociclib

Regimen

Endocrine therapy

• Exemestane (Aromasin)

Targeted therapy

• Palbociclib (Ibrance)

FAP

FAP: Fluorouracil, Alfa interferon, Platinol (Cisplatin)

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Cisplatin (Platinol)

Immunotherapy

• Interferon alfa-2b (Intron-A)

FEC & HP

FEC & HP: Fluorouracil, Epirubicin, Cyclophosphamide, Herceptin (Trastuzumab), Pertuzumab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Epirubicin (Ellence)
• Cyclophosphamide (Cytoxan)

Targeted therapy

• Trastuzumab (Herceptin)
• Pertuzumab (Perjeta)

FEC-KP

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Epirubicin (Ellence)
• Fluorouracil (5-FU)

Targeted therapy

• Pertuzumab (Perjeta)

Antibody-drug conjugate therapy

• Trastuzumab emtansine (Kadcyla)

FLA

FLA: FLudarabine & Ara-C (Cytarabine)

Regimen

Chemotherapy

• Fludarabine (Fludara)
• Cytarabine (Ara-C)

FLAG-Ida & GO

FLAG-Ida & GO: FLudarabine, Ara-C (Cytarabine), G-CSF (Lenograstim), Idarubicin, Gemtuzumab Ozogamicin

Regimen {{#subobject:44e85e|Variant=1}}

Chemotherapy

• Fludarabine (Fludara) 30 mg/m² IV once per day on days 2 to 6
• Cytarabine (Ara-C) 2000 mg/m² IV over 4 hours once per day on days 2 to 6, given 4 hours after fludarabine
• Idarubicin (Idamycin) 8 mg/m² IV once per day on days 4 to 6

Growth factor therapy

• Lenograstim (Granocyte)

Antibody-drug conjugate therapy

• Gemtuzumab ozogamicin (Mylotarg)

FLAI

FLAI: FLudarabine, Ara-C (Cytarabine), Idarubicin
FIA: Fludarabine, Idarubicin, Ara-C (Cytarabine)

Regimen

Chemotherapy

• Fludarabine (Fludara)
• Cytarabine (Ara-C)
• Idarubicin (Idamycin)

Fluorouracil & Gemcitabine

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Gemcitabine (Gemzar)

Fluorouracil & Interferon alfa-2a

Regimen

Chemotherapy

• Fluorouracil (5-FU)

Immunotherapy

• Interferon alfa-2a (Roferon-A)

Fluorouracil & Interferon alfa-2b

Regimen

Chemotherapy

• Fluorouracil (5-FU)

Immunotherapy

• Interferon alfa-2b (Intron-A)

Fluorouracil & Melphalan

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Melphalan (Alkeran)

Fluorouracil & Vinorelbine

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Vinorelbine (Navelbine)

Fluorouracil, Interferon alfa-2a, Interleukin-2

Regimen

Chemotherapy

• Fluorouracil (5-FU)

Immunotherapy

• Aldesleukin (Proleukin)
• Interferon alfa-2a (Roferon-A)

Fluorouracil, Levamisole, RT

Regimen

Chemotherapy

• Fluorouracil (5-FU)

Immunotherapy

• Levamisole (Ergamisol)

Radiotherapy

• External beam radiotherapy

Fluorouracil, Olaparib, Bevacizumab

Regimen

Chemotherapy

• Fluorouracil (5-FU)

Targeted therapy

• Bevacizumab (Avastin)
• Olaparib (Lynparza)

Fluorouracil, Semustine, RT

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Semustine (MeCCNU)

Radiotherapy

• External beam radiotherapy

Fluorouracil, Semustine, Vincristine

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Semustine (MeCCNU)
• Vincristine (Oncovin)

FNC & RT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Mitoxantrone (Novantrone)
• Fluorouracil (5-FU)

Radiotherapy

• External beam radiotherapy

FOLF-CB

FOLF-CB: FOLinic acid (Leucovorin), Fluorouracil, Cetuximab, Bevacizumab

Regimen

Chemotherapy

• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)

Targeted therapy

• Cetuximab (Erbitux)
• Bevacizumab (Avastin)

FOLFIRI & Regorafenib

FOLFIRI & Regorafenib: FOLinic acid (Leucovorin), Fluorouracil, IRInotecan, Regorafenib

Regimen

Chemotherapy

• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)
• Irinotecan (Camptosar)

Targeted therapy

• Regorafenib (Stivarga)

FOLFIRI & Simvastatin

FOLFIRI & Simvastatin: FOLinic acid (Leucovorin), Fluorouracil, IRInotecan, Simvastatin

Regimen

Chemotherapy

• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)
• Irinotecan (Camptosar)

Targeted therapy

• Simvastatin (Zocor)

FOLFIRI & Sunitinib

FOLFIRI & Sunitinib: FOLinic acid (Leucovorin), Fluorouracil, IRInotecan, Sunitinib

Regimen

Chemotherapy

• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)
• Irinotecan (Camptosar)

Targeted therapy

• Sunitinib (Sutent)

FOLFIRI, Bevacizumab, Cetuximab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Irinotecan (Camptosar)

Targeted therapy

• Bevacizumab (Avastin)
• Cetuximab (Erbitux)

FOLFOX4 & Cediranib

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Oxaliplatin (Eloxatin)
• Leucovorin (Folinic acid)

Targeted therapy

• Cediranib (Recentin)

FULV & Cisplatin

FULV & Cisplatin: 5-FU, LeucoVorin, Cisplatin

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

FULV & Edrecolomab

FULV & Edrecolomab: 5-FU, LeucoVorin, Edrecolomab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

Targeted therapy

• Edrecolomab (Panorex)

FULV & Interferon alfa-2a

FULV & Interferon alfa-2a: 5-FU, LeucoVorin, Interferon alfa-2a

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

Immunotherapy

• Interferon alfa-2a (Roferon-A)

FULV & Interferon alfa-2b

FULV & Interferon alfa-2b: 5-FU, LeucoVorin, Interferon alfa-2b

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

Immunotherapy

• Interferon alfa-2b (Intron-A)

FULV & Interferon alfa-2c

FULV & Interferon alfa-2c: 5-FU, LeucoVorin, Interferon alfa-2c

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

Immunotherapy

• Interferon alfa-2c (Berofor)

FULV & Interleukin-2

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

Immunotherapy

• Aldesleukin (Proleukin)

FULV & Trimetrexate

FULV & Trimetrexate: 5-FU, LeucoVorin, Trimetrexate

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Trimetrexate (Neutrexin)

Fulvestrant & Bevacizumab

Regimen

Endocrine therapy

• Fulvestrant (Faslodex)

Targeted therapy

• Bevacizumab (Avastin)

Fulvestrant & Lapatinib

Regimen

Endocrine therapy

• Fulvestrant (Faslodex)

Targeted therapy

• Lapatinib (Tykerb)

Gefitinib & Simvastatin

Regimen

Chemotherapy

• Simvastatin (Zocor)

Targeted therapy

• Gefitinib (Iressa)

Gemcitabine & Axitinib

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Axitinib (Inlyta)

Gemcitabine & Cetuximab

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Cetuximab (Erbitux)

Gemcitabine & Cisplatin (GC) & LD IL-2

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Cisplatin (Platinol)

Immunotherapy

• Aldesleukin (Proleukin)

Gemcitabine & Ganitumab

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Ganitumab (AMG-479)

Gemcitabine & Irinotecan (IG)

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Irinotecan (Camptosar)

Gemcitabine & Masitinib

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Masitinib (AB-1010)

Gemcitabine & Pemetrexed

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Pemetrexed (Alimta)

Gemcitabine & Pertuzumab

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Pertuzumab (Perjeta)

Gemcitabine & Sorafenib

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Sorafenib (Nexavar)

Gemcitabine & Topotecan

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Topotecan (Hycamtin)

Gemcitabine & Treosulfan

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Treosulfan (Ovastat)

Gemcitabine & Vandetanib

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Vandetanib (Caprelsa)

Gemcitabine & Vinorelbine (GN)

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Vinorelbine (Navelbine)

Gemcitabine & Vismodegib

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Vismodegib (Erivedge)

Gemcitabine & Ziv-aflibercept

Regimen

Chemotherapy

• Gemcitabine (Gemzar)

Targeted therapy

• Ziv-aflibercept (Zaltrap)

Glasdegib monotherapy

Regimen

Targeted therapy

• Glasdegib (Daurismo)

GVP

GVP: Gemcitabine, Vinorelbine, Platinol (Cisplatin)

Regimen

Chemotherapy

• Gemcitabine (Gemzar)
• Vinorelbine (Navelbine)
• Cisplatin (Platinol)

HiDAC & Etoposide

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Etoposide (Vepesid)

HiDAC & Mitoxantrone

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Mitoxantrone (Novantrone)

HiDAC & Quizartinib

Regimen

Chemotherapy

• Cytarabine (Ara-C)

Targeted therapy

• Quizartinib (Vanflyta)

HiDAC & Sorafenib

Regimen

Chemotherapy

• Cytarabine (Ara-C)

Targeted therapy

• Sorafenib (Nexavar)

HiDAC+3d

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Daunorubicin (Cerubidine)

HiDAC+3i

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Idarubicin (Idamycin)

ICE, ATRA, GO

ICE, ATRA, GO: Idarubicin, Cytarabine, Etoposide, All-Trans Retinoic Acid, Gemtuzumab Ozogamicin

Regimen

Chemotherapy

• Idarubicin (Idamycin)
• Cytarabine (Ara-C)
• Etoposide (Vepesid)

Targeted therapy

• All-trans retinoic acid (ATRA)

Antibody-drug conjugate therapy

• Gemtuzumab ozogamicin (Mylotarg)

IFL & RT

Regimen

Chemotherapy

• Irinotecan (Camptosar)
• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)

Radiotherapy

• External beam radiotherapy

Interferon alfa-2a & Temsirolimus

Regimen

Immunotherapy

• Interferon alfa-2a (Roferon-A)

Targeted therapy

• Temsirolimus (Torisel)

Interferon alfa-2a & Vinblastine

Regimen

Chemotherapy

• Vinblastine (Velban)

Immunotherapy

• Interferon alfa-2a (Roferon-A)

Interferon gamma-1b monotherapy

Regimen

Immunotherapy

• Interferon gamma-1b (Actimmune)

Ipatasertib & Paclitaxel

Regimen

Chemotherapy

• Paclitaxel (Taxol)

Targeted therapy

• Ipatasertib (GDC-0068)

Ixabepilone & Bevacizumab

Regimen

Chemotherapy

• Ixabepilone (Ixempra)

Targeted therapy

• Bevacizumab (Avastin)

Lenalidomide & Rituximab (R2) & Tafasitamab

Regimen

Targeted therapy

• Lenalidomide (Revlimid)
• Rituximab (Rituxan)
• Tafasitamab (Monjuvi)

Lenvatinib & Atezolizumab

Regimen

Immunotherapy

• Atezolizumab (Tecentriq)

Targeted therapy

• Lenvatinib (Lenvima)

Letrozole & Everolimus

Regimen

Endocrine therapy

• Letrozole (Femara)

Targeted therapy

• Everolimus (Afinitor)

Letrozole & Temsirolimus

Regimen

Endocrine therapy

• Letrozole (Femara)

Targeted therapy

• Temsirolimus (Torisel)

Levamisole & RT

Regimen

Immunotherapy

• Levamisole (Ergamisol)

Radiotherapy

• External beam radiotherapy

Lobaplatin & RT

Regimen

Chemotherapy

• Lobaplatin (D-19466)

Radiotherapy

• External beam radiotherapy

LoDAC & Volasertib

Regimen

Chemotherapy

• Cytarabine (Ara-C)

Targeted therapy

• Volasertib (BI-6727)

LoDAC & Vosaroxin

Regimen

Chemotherapy

• Cytarabine (Ara-C)
• Vosaroxin (SNS-595)

Lomustine & RT

Regimen

Chemotherapy

• Lomustine (CCNU)

Radiotherapy

• External beam radiotherapy

Lomustine, Melphalan, TBI, then auto HSCT

Regimen

Chemotherapy

• Lomustine (CCNU)
• Melphalan (Alkeran)

Radiotherapy

• External beam radiotherapy

Lomustine, Melphalan, TBI

Regimen

Chemotherapy

• Lomustine (CCNU)
• Melphalan (Alkeran)

Radiotherapy

• External beam radiotherapy

ME

ME: Mitoxantrone & Etoposide

Regimen

Chemotherapy

• Mitoxantrone (Novantrone)
• Etoposide (Vepesid)

Mechlorethamine & RT

Regimen

Chemotherapy

• Mechlorethamine (Mustargen)

Radiotherapy

• External beam radiotherapy

Melphalan & Busulfan, then auto HSCT

Regimen

Chemotherapy

• Busulfan (Myleran)
• Melphalan (Alkeran)

Melphalan & Busulfan

Regimen

Chemotherapy

• Busulfan (Myleran)
• Melphalan (Alkeran)

Melphalan & TBI, then auto HSCT

Regimen

Chemotherapy

• Melphalan (Alkeran)

Radiotherapy

• External beam radiotherapy

MEV

MEV: Mitomycin, Etoposide, Vindesine

Regimen

Chemotherapy

• Mitomycin (Mutamycin)
• Etoposide (Vepesid)
• Vindesine (Eldisine)

MFL

MFL: Methyl-lomustine (MeCCNU), 5-FU, Leucovorin

Regimen

Chemotherapy

• Semustine (MeCCNU)
• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)

mFOLFOX6, Atezolizumab, Bevacizumab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Oxaliplatin (Eloxatin)

Immunotherapy

• Atezolizumab (Tecentriq)

Targeted therapy

• Bevacizumab (Avastin)

mFOLFOX6, Bevacizumab, Cetuximab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Oxaliplatin (Eloxatin)

Targeted therapy

• Bevacizumab (Avastin)
• Cetuximab (Erbitux)

mFOLFOX6, Bevacizumab, Panitumumab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Oxaliplatin (Eloxatin)

Targeted therapy

• Bevacizumab (Avastin)
• Panitumumab (Vectibix)

mFOLFOX6, Lenvatinib, Pembrolizumab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Oxaliplatin (Eloxatin)

Immunotherapy

• Pembrolizumab (Keytruda)

Targeted therapy

• Lenvatinib (Lenvima)

mFOLFOXIRI & Panitumumab

Regimen

Chemotherapy

• Fluorouracil (5-FU)
• Leucovorin (Folinic acid)
• Oxaliplatin (Eloxatin)
• Irinotecan (Camptosar)

Targeted therapy

• Panitumumab (Vectibix)

MFT

MFL: Methotrexate, 5-FU, Tamoxifen

Regimen

Chemotherapy

• Methotrexate (MTX)
• Fluorouracil (5-FU)

Endocrine therapy

• Tamoxifen (Nolvadex)

mini-CHVP

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)
• Teniposide (Vumon)

Glucocorticoid therapy

• Prednisone (Sterapred)

Mitomycin & RT

Regimen

Chemotherapy

• Mitomycin (Mutamycin)

Radiotherapy

• External beam radiotherapy

Mitomycin & Vinblastine

Regimen

Chemotherapy

• Mitomycin (Mutamycin)
• Vinblastine (Velban)

Mitoxantrone & Hydrocortisone

Regimen

Chemotherapy

• Mitoxantrone (Novantrone)

Endocrine therapy

• Hydrocortisone (Cortef)

Mitoxantrone, Vincristine, Prednisolone

Regimen

Chemotherapy

• Mitoxantrone (Novantrone)
• Vincristine (Oncovin)

Glucocorticoid therapy

• Prednisolone (Millipred)

MMF

MMF: Methyl-lomustine (MeCCNU), Mitomycin, 5-FU

Regimen

Chemotherapy

• Semustine (MeCCNU)
• Mitomycin (Mutamycin)
• Fluorouracil (5-FU)

MOPPEBVCAD

MOPPEBVCAD: Mechlorethamine, Oncovin (Vincristine), Procarbazine, Prednisone, Epirubicin, Bleomycin, Vinblastine, CCNU (Lomustine), Adriamycin (Doxorubicin), DVA (Vindesine)

Regimen

Chemotherapy

• Mechlorethamine (Mustargen)
• Vincristine (Oncovin)
• Procarbazine (Matulane)
• Epirubicin (Ellence)
• Bleomycin (Blenoxane)
• Vinblastine (Velban)
• Lomustine (CCNU)
• Doxorubicin (Adriamycin)
• Vindesine (Eldisine)

Glucocorticoid therapy

• Prednisone (Sterapred)

MPP

MPP: Melphalan, Prednisone, Procarbazine

Regimen

Chemotherapy

• Melphalan (Alkeran)
• Procarbazine (Matulane)

Glucocorticoid therapy

• Prednisone (Sterapred)

MTP

MTP: Myocet (Non-pegylated liposomal doxorubicin), Trastuzumab, Paclitaxel

Regimen

Chemotherapy

• Non-pegylated liposomal doxorubicin (Myocet)
• Paclitaxel (Taxol)

Targeted therapy

• Trastuzumab (Herceptin)

MVC

MVC: Mitomycin, Vindesine, Carboplatin

Regimen

Chemotherapy

• Mitomycin (Mutamycin)
• Vindesine (Eldisine)
• Carboplatin (Paraplatin)

Neratinib & Paclitaxel

Regimen

Targeted therapy

• Neratinib (Nerlynx)

Chemotherapy

• Paclitaxel (Taxol)

Nimustine, Procarbazine, RT

Regimen

Chemotherapy

• Nimustine (ACNU)
• Procarbazine (Matulane)

Radiotherapy

• External beam radiotherapy

Nintedanib monotherapy

Regimen

Targeted therapy

• Nintedanib (Vargatef)

NIP

NIP: Navelbine (Vinorelbine), Ifosfamide, Platinol (Cisplatin)

Regimen

Chemotherapy

• Vinorelbine (Navelbine)
• Ifosfamide (Ifex)
• Cisplatin (Platinol)

Niraparib & Dostarlimab

Regimen

Immunotherapy

• Dostarlimab (Jemperli)

Targeted therapy

• Niraparib (Zejula)

Niraparib & Pembrolizumab

Regimen

Immunotherapy

• Pembrolizumab (Keytruda)

Targeted therapy

• Niraparib (Zejula)

Nolatrexed monotherapy

Regimen

Chemotherapy

• Nolatrexed (Thymitaq)

Paclitaxel & Atezolizumab

Regimen

Chemotherapy

• Paclitaxel (Taxol)

Immunotherapy

• Atezolizumab (Tecentriq)

Paclitaxel & Pertuzumab

Regimen

Chemotherapy

• Paclitaxel (Taxol)

Targeted therapy

• Pertuzumab (Perjeta)

Paclitaxel & Sunitinib

Regimen

Chemotherapy

• Paclitaxel (Taxol)

Targeted therapy

• Sunitinib (Sutent)

Paclitaxel & Trastuzumab (TH) & Everolimus

TH & Everolimus: Taxol (Paclitaxel), Herceptin (Trastuzumab), Everolimus

Regimen

Chemotherapy

• Docetaxel (Taxotere)

Targeted therapy

• Trastuzumab (Herceptin)
• Everolimus (Afinitor)

Paclitaxel & Trebananib

Regimen

Chemotherapy

• Paclitaxel (Taxol)

Targeted therapy

• Trebananib (AMG-386)

Palbociclib & Tamoxifen

Regimen

Endocrine therapy

• Tamoxifen (Nolvadex)

Targeted therapy

• Palbociclib (Ibrance)

Panitumumab & RT

Regimen

Targeted therapy

• Panitumumab (Vectibix)

Radiotherapy

• External beam radiotherapy

Pazopanib/Everolimus

Regimen

Targeted therapy

• Everolimus (Afinitor)
• Pazopanib (Votrient)

PD & Pembrolizumab

PD & Pembrolizumab: Pomalidomide, Dexamethasone, Pembrolizumab

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Mateos et al. 2019 (KEYNOTE-183)	2016-2017	Phase 3 (E-esc)	PD	Seems to have inferior PFS (HR 1.53, 95% CI 1.05-2.22)

Targeted therapy

• Pomalidomide (Pomalyst)

Glucocorticoid therapy

• Dexamethasone (Decadron)

Immunotherapy

• Pembrolizumab (Keytruda)

Pegylated liposomal doxorubicin & Trebananib

Regimen

Study	Dates of enrollment	Evidence	Comparator	Comparative Efficacy
Marth et al. 2016 (TRINOVA-2)	2011-2013	Phase 3 (E-esc)	PLD	Did not meet primary endpoint of PFS (HR 0.92, 95% CI 0.68-1.24)

Chemotherapy

• Pegylated liposomal doxorubicin (Doxil)

Targeted therapy

• Trebananib (AMG-386)

PEI

PEI: Platinol (Cisplatin), Etoposide, Ifosfamide

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Etoposide (Vepesid)
• Ifosfamide (Ifex)

PELF

PELF: Platinol (Cisplatin), Epirubicin, Leucovorin, 5-FU

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Epirubicin (Ellence)
• Leucovorin (Folinic acid)
• Fluorouracil (5-FU)

Pembrolizumab & RT

Regimen

Immunotherapy

• Pembrolizumab (Keytruda)

Radiotherapy

• External beam radiotherapy

Pemetrexed & Cetuximab

Regimen

Chemotherapy

• Pemetrexed (Alimta)

Targeted therapy

• Cetuximab (Erbitux)

Pemetrexed & Vandetanib

Regimen

Chemotherapy

• Pemetrexed (Alimta)

Targeted therapy

• Vandetanib (Caprelsa)

PGT

PGT: Platinol (Cisplatin), Gemcitabine, Taxol (Paclitaxel)

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)
• Paclitaxel (Taxol)

PGV

PGV: Platinol (Cisplatin), Gemcitabine, Vinorelbine
CGV: Cisplatin, Gemcitabine, Vinorelbine

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Gemcitabine (Gemzar)
• Vinorelbine (Navelbine)

Pixantrone & Rituximab

Regimen

Chemotherapy

• Pixantrone (Pixuvri)

Targeted therapy

• Rituximab (Rituxan)

Pravastatin & Sorafenib

Regimen

Chemotherapy

• Pravastatin (Pravachol)

Targeted therapy

• Sorafenib (Nexavar)

Procarbazine & RT

Regimen

Chemotherapy

• Procarbazine (Matulane)

Radiotherapy

• External beam radiotherapy

PVI

PVI: Platinol (Cisplatin), Vindesine, Ifosfamide
VIP: Vindesine, Ifosfamide, Platinol (Cisplatin)

Regimen

Chemotherapy

• Cisplatin (Platinol)
• Vindesine (Eldisine)
• Ifosfamide (Ifex)

R-BEACOPP

R-BEACOPP: Rituximab, Bleomycin, Etoposide, Adriamycin (Doxorubicin), Cyclophosphamide, Oncovin (Vincristine), Procarbazine, Prednisone

Regimen

Targeted therapy

• Rituximab (Rituxan)

Chemotherapy

• Bleomycin (Blenoxane)
• Etoposide (Vepesid)
• Doxorubicin (Adriamycin)
• Cyclophosphamide (Cytoxan)
• Vincristine (Oncovin)
• Procarbazine (Matulane)

Glucocorticoid therapy

• Prednisone (Sterapred)

R-MegaCHOEP

R-MegaCHOEP: Rituximab, high-dose (Mega) Cyclophosphamide, Hydroxydaunorubicin (Doxorubicin), Oncovin (Vincristine), Etoposide, Prednisone

Targeted therapy

• Rituximab (Rituxan)

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Doxorubicin (Adriamycin)
• Vincristine (Oncovin)
• Etoposide (Vepesid)

Glucocorticoid therapy

• Prednisone (Sterapred)

Realgar-Indigo naturalis formulation monotherapy

Regimen

Targeted therapy

• Realgar-Indigo naturalis formulation

Semustine & RT

Regimen

Chemotherapy

• Semustine (MeCCNU)

Radiotherapy

• External beam radiotherapy

Sorafenib & Atezolizumab

Regimen

Immunotherapy

• Atezolizumab (Tecentriq)

Targeted therapy

• Sorafenib (Nexavar)

Tamoxifen & Everolimus

Regimen

Endocrine therapy

• Tamoxifen (Nolvadex)

Targeted therapy

• Everolimus (Afinitor)

Tamoxifen & RT

Regimen

Endocrine therapy

• Tamoxifen (Nolvadex)

Radiotherapy

• External beam radiotherapy

TCG

TCG: Taxol (Paclitaxel), Carboplatin, Gemcitabine

Regimen

Chemotherapy

• Paclitaxel (Taxol)
• Carboplatin (Paraplatin)
• Gemcitabine (Gemzar)

TCHL (Docetaxel)

TCHL: Taxotere (Docetaxel), Carboplatin, Herceptin (Trastuzumab), Lapatinib

Regimen

Chemotherapy

• Docetaxel (Taxotere)
• Carboplatin (Paraplatin)

Targeted therapy

• Trastuzumab (Herceptin)
• Lapatinib (Tykerb)

TCL (Docetaxel)

TCL: Taxotere (Docetaxel), Carboplatin, Lapatinib

Regimen

Chemotherapy

• Docetaxel (Taxotere)
• Carboplatin (Paraplatin)

Targeted therapy

• Lapatinib (Tykerb)

TEC

TEC: Taxol (Paclitaxel), Epirubicin, Carboplatin

Regimen

Chemotherapy

• Paclitaxel (Taxol)
• Epirubicin (Ellence)
• Carboplatin (Paraplatin)

Temozolomide, Bevacizumab, RT

Regimen

Chemotherapy

• Temozolomide (Temodar)

Targeted therapy

• Bevacizumab (Avastin)

Radiotherapy

• External beam radiotherapy

Temozolomide, Nivolumab, RT

Regimen

Chemotherapy

• Temozolomide (Temodar)

Immunotherapy

• Nivolumab (Opdivo)

Radiotherapy

• External beam radiotherapy

Teniposide & RT

Regimen

Chemotherapy

• Teniposide (Vumon)

Radiotherapy

• External beam radiotherapy

Tipifarnib monotherapy

Regimen

Targeted therapy

• Tipifarnib (Zarnestra)

Tivantinib monotherapy

Regimen

Targeted therapy

• Tivantinib (ARQ-197)

TPCV

TPCV: Thioguanine, Procarbazine, CCNU, Vincristine

Regimen

Chemotherapy

• Thioguanine (Tabloid)
• Procarbazine (Matulane)
• Lomustine (CCNU)
• Vincristine (Oncovin)

VAC & RT

Regimen

Chemotherapy

• Cyclophosphamide (Cytoxan)
• Dactinomycin (Cosmegen)
• Vincristine (Oncovin)

Radiotherapy

• External beam radiotherapy

VADx

VADx: Vincristine, Ara-C (Cytarabine), Dexamethasone

Regimen

Chemotherapy

• Vincristine (Oncovin)
• Cytarabine (Ara-C)

Glucocorticoid therapy

• Dexamethasone (Decadron)

VAPEC-B

VAPEC-B: Vincristine, Adriamycin (Doxorubicin), Prednisolone, Etoposide, Cyclophosphamide, Bleomycin

Regimen

Chemotherapy

• Vincristine (Oncovin)
• Doxorubicin (Adriamycin)
• Etoposide (Vepesid)
• Cyclophosphamide (Cytoxan)
• Bleomycin (Blenoxane)

Glucocorticoid therapy

• Prednisolone (Millipred)

VBM (Vinblastine)

VBM: Vinblastine, Bleomycin, Methotrexate

Regimen

Chemotherapy

• Vinblastine (Velban)
• Bleomycin (Blenoxane)
• Methotrexate (MTX)

VCE

VCE: Vincristine, Carboplatin, Etoposide

Regimen

Chemotherapy

• Vincristine (Oncovin)
• Carboplatin (Paraplatin)
• Etoposide (Vepesid)

Vinorelbine & Hydrocortisone

Regimen

Chemotherapy

• Vinorelbine (Navelbine)

Endocrine therapy

• Hydrocortisone (Cortef)

VNC

VNC: Vincristine, Novantrone (Mitoxantrone), Cyclophosphamide

Regimen

Chemotherapy

• Vincristine (Oncovin)
• Mitoxantrone (Novantrone)
• Cyclophosphamide (Cytoxan)

VPV

VPV: Vinblastine, Platinol (Cisplatin), VP-16 (Etoposide)

Regimen

Chemotherapy

• Vinblastine (Velban)
• Cisplatin (Platinol)
• Etoposide (Vepesid)

VTDC

VTDC: Velcade (Bortezomib), Thalidomide, Dexamethasone, Cyclophosphamide

Regimen

Targeted therapy

• Bortezomib (Velcade)
• Thalidomide (Thalomid)

Glucocorticoid therapy

• Dexamethasone (Decadron)

Chemotherapy

• Cyclophosphamide (Cytoxan)