Vincristine (Oncovin)

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General information

Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.[1][2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Diseases for which it was used

Notable side effects

Patient drug information

History of changes in FDA indication

  • 7/10/1963: Initial FDA approval

Also known as

Synonyms
Alcrist Biocrist Biocrystin Cellcristin Citomid Crivosin Cytomid Farmistin CS
Fauldvincri Krebin Kyocristine Nevexitin Onkocristin Pericristine Pharmacristine Tecnocris
Vincasar Vinces Vincosid Vincran Vincrex Vincrifil Vincrin Vincrisin
Vincrisol Vincristin Vincristina Vincristinesulfaat Vincristinsulfat Vincristinum Vincrisul Vinracin
Vinracine Vinstin Vintec

References

  1. 1.0 1.1 Vincristine (Oncovin) package insert
  2. Vincristine (Oncovin) package insert (locally hosted backup)
  3. Broyl A, Corthals SL, Jongen JL, van der Holt B, Kuiper R, de Knegt Y, van Duin M, el Jarari L, Bertsch U, Lokhorst HM, Durie BG, Goldschmidt H, Sonneveld P. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21. link to original article contains verified protocol PubMed
  4. Vincristine (Oncovin) patient drug information (Chemocare)
  5. Vincristine (Oncovin) patient drug information (UpToDate)