Ziv-aflibercept (Zaltrap)

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General information

Class/mechanism: Recombinant fusion protein between the Fc portion of human IgG1 and the extracellular domains of VEGF receptor 1 & 2 (VEGFR 1 & VEGFR 2), which binds VEGF-A and VEGF-B (vascular endothelial growth factor), as well as PGF (placental growth factor). By binding to and inhibiting these angiogenic growth factors, their neovascular activity, and vascular permeability, ziv-aflibercept inhibits tumor angiogenesis.[1][2]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

History of changes in EMA indication

  • 2013-02-01: Initial marketing authorization as Zaltrap.

History of changes in Health Canada indication

  • 2014-02-12: Initial notice of compliance

History of changes in PMDA indication

  • 2017-03-30: Initial approval for the treatment of unresectable advanced or recurrent colorectal cancer.

Also known as

  • Generic names: aflibercept, aflibercept beta, VEGF trap, ziv-aflibercept
  • Brand names: Zaltrap