Class/mechanism: Monovalent (one-armed) monoclonal antibody that binds to the extracellular Sema domain of c-Met and inhibits binding of hepatocyte growth factor (HGF). This interferes with ligand-dependent c-Met dimerization, activation of the intracellular kinase domain, and downstream signals that normally promote tumor proliferation, survival, and metastasis. The monovalent design was chosen to avoid potentially activating Met through dimerization of two Met molecules by onartuzumab.
Extravasation: no information
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Patient drug information
No information available.
Also known as
- Code names: MetMAb, RO5490258