Cisplatin (Platinol)

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General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.[1][2]
Route: IV, intracavitary (intraperitoneal)
Extravasation: vesicant (concentration ≥0.5 mg/mL)/irritant (concentration <0.5 mg/mL)

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 12/19/1978: Initial FDA approval

Also known as

  • Code name: NSC 119875
  • Generic names: CDDP, cis-diamminedichloroplatinum III, cis-platinum, cisplatinum, DACP, DDP
  • Brand names:
Abiplatin Axiplat Biocisplatinum Bioplatino Blastolem Briplatin Brisplatin C-Platin
Ceplatin Ciplatan Ciplexal Cis-GRY Cismaplat Cispatin Cisplamerck Cisplan
Cisplasol Cisplatex Cisplatine Cisplatino Cisplatyl Cisteen Citoplatino Cytoplatin
Docistin Elvecis Fauldcispla Ifapla Kemoplat Lederplatin Metaplatin Neoplat
Neoplatin Noveldexis Oncoplatin AQ Placis Platamin Platamine Platiblastin Platicis
Platidiam Platikem Platil Platimit Platin Platinil Platino II Filaxis Platinol
Platinox Platinoxan Platiran Platistil Platistin Platistine Platosin Randa
Romcis Sicatem Sinplatin Sisplanil Tecnoplatin Tisplal Unistin


  1. 1.0 1.1 Cisplatin (Platinol) package insert
  2. Cisplatin (Platinol) package insert (locally hosted backup)
  3. Cisplatin (Platinol) patient drug information (Chemocare)
  4. Cisplatin (Platinol) patient drug information (UpToDate)