Interferon alfa-2a (Roferon-A)
Class/mechanism: Immune system activator; binds to human type 1 interferon, activating downstream intracellular signal transduction pathways initially mediated by the JAK/STAT pathway. Interferon α-2a activates multiple biologic effects which are not fully understood.
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Diseases for which it is used
- Chronic myelogenous leukemia
- Follicular lymphoma
- Hairy cell leukemia
- Kaposi sarcoma
- Neuroendocrine tumor
- Renal cell carcinoma
- Cutaneous squamous cell carcinoma
Diseases for which it was used
Patient drug information
- Interferon alfa-2a (Roferon-A) package insert
- Interferon alfa-2a (Roferon-A) patient drug information (Chemocare)
History of changes in FDA indication
- 6/4/1986: Initial FDA approval for treatment of patients 18 years of age or older with hairy cell leukemia
- Uncertain date: In addition, it is indicated for chronic phase, Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) patients who are minimally pretreated (within 1 year of diagnosis).
Also known as
- Brand name: Laroferon, Roferon-A