Interferon alfa-2a (Roferon-A)
Class/mechanism: Immune system activator; binds to human type 1 interferon, activating downstream intracellular signal transduction pathways initially mediated by the JAK/STAT pathway. Interferon α-2a activates multiple biologic effects which are not fully understood.
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Diseases for which it is used
- Chronic myelogenous leukemia
- Follicular lymphoma
- Neuroendocrine tumors
- Renal cancer
- Squamous cell carcinoma (SCC)
Patient drug information
History of changes in FDA indication
- 6/4/1986: Initial FDA approval