Ifosfamide (Ifex)

From HemOnc.org - A Hematology Oncology Wiki
Jump to navigation Jump to search

General information

Class/mechanism: Nitrogen mustard, alkylator. Metabolites of ifosfamide interact with DNA to produce phosphotriesters and formation of DNA cross-links. Ifosfamide requires metabolic activation by microsomal liver enzymes to form its active metabolites.[1][2]
Route: IV
Extravasation: irritant or neutral, depending on reference

  • A protective agent such as Mesna (Mesnex) should be used concurrently with ifosfamide to help prevent hemorrhagic cystitis.

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is established (work in progress)

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

  • 1988-12-30: Initial approval in combination with certain other approved antineoplastic agents for third-line chemotherapy of germ cell testicular cancer. It should ordinarily be used in combination with a prophylactic agent for hemorrhagic cystitis, such as mesna. (Based on Loehrer et al. 1986)

History of changes in EMA indication

  • 1976-07-13: EURD

History of changes in PMDA indication

  • 2012-03-21: New additional indication and a new dosage for the treatment of malignant lymphoma.

Also known as

  • Brand names:
Alquimid Duvaxan Fentul Fosfidex Haloxan
Holoxan Holoxane Ifex IFO Cell Ifocris
Ifolem Ifomida Ifomide Ifos Ifosfamida
Ifoxan IFX Ipamide Isophosphamide Isoxan
Macdafen Mitoxana Tronoxal