Vadimezan (AS-A404)

Mechanism of action

From the NCI Drug Dictionary: A fused tricyclic analog of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.

Diseases for which is was unsuccessful

• Non-small cell lung cancer

Also known as

• Code names: AS-1404, AS-A404