Semustine (MeCCNU)

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General information

Class/mechanism: Nitrosourea, alkylates DNA and RNA and may inhibit certain key enzymatic reactions by carbamoylation of amino acids in proteins. Very similar to lomustine, with a methyl group added.
Route: PO
Extravasation: n/a

Diseases for which it was used

Also known as

  • Generic names: MeCCNU, methyl-CCNU, methyl-lomustine
  • Brand names: Semustina