Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase. Vinorelbine may possibly also disrupt: amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent calcium transport ATPase activity; and DNA/RNA and lipid synthesis.
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Disease for which it is used
- Breast cancer
- Cervical cancer
- Diffuse large B-cell lymphoma
- Hodgkin lymphoma
- Non-small cell lung cancer
- Ovarian cancer
- Soft tissue sarcoma
- Small cell lung cancer
Patient drug information
- Vinorelbine (Navelbine) patient drug information (Chemocare)
- Vinorelbine (Navelbine) patient drug information (UpToDate)
History of changes in FDA indication
- 12/23/1994: Initial FDA approval