Enzalutamide (Xtandi)

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General information

Class/mechanism: Antiandrogen; androgen receptor inhibitor (ARI) or androgen receptor signaling inhibitor (ARSI). Enzalutamide competitively inhibits testosterone from binding to the androgen receptor, interferes with translocation of the androgen receptor to the nucleus, and inhibits binding to DNA, resulting in decreased prostate cancer proliferation and cell death.[1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code name: MDV3100
  • Brand name: Xtandi


  1. 1.0 1.1 Enzalutamide (Xtandi) package insert
  2. Enzalutamide (Xtandi) package insert (locally hosted backup)
  3. Xtandi manufacturer's website
  4. Enzalutamide (Xtandi) patient drug information (Chemocare)
  5. Enzalutamide (Xtandi) patient drug information (UpToDate)