Doxorubicin (Adriamycin)

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General information

Class/mechanism: Anthracycline; binds and intercalates into DNA, inhibiting nucleotide replication and DNA/RNA polymerase activity. Intercalation of DNA triggers DNA cleavage via topoisomerase II. Toxic effects on organs may be related to cell membrane lipid binding activities; enzymatic electron reduction of doxorubicin creates reactive species, e.g. hydroxyl free radicals OH-, which has been implicated in cardiotoxicity by means of Cu (II) and Fe (III) reduction.[1][2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Generic name: hydroxydaunorubicin
  • Brand names:
Adriablastina Adriacept Adriacin Adriamycin Adriblastin Adriblastina Adriblastine Adricept
Adricin Adrim Adrimedac Adrosal Antraciclin Biorrub Biorubina Cadria
Carcinocin Cloridrato DE Doxorrubicina Colhidrol Daxotel Deldoxin Dicladox Dobicin Dobixin
Doxo Doxobin Doxo Cell Doxocris Doxokebir Doxolem Doxonolver Doxor
Doxorrubicina Doxoruben Doxorubicina Doxorubicine Doxorubicinum Doxorubin Doxotec Doxtie
Duxocin Evacet Farmiblastina Fauldoxo Flavicina Ifadox Kemodoxa Lipodox
Lyphidox Myocet Nagun Neoxane Nuaze Oncodria Onkodox Onkostatil
Pallagicin Ranxas Rastocin Ribodoxo Roxorin Rubex Varidoxo Zodox


  1. 1.0 1.1 1.2 Doxorubicin (Adriamycin) package insert
  2. Doxorubicin (Adriamycin) package insert (locally hosted backup)
  3. Doxorubicin (Adriamycin) patient drug information (Chemocare)
  4. Doxorubicin (Adriamycin) patient drug information (UpToDate)