Carboplatin (Paraplatin)

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General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.[1][2]

Route: IV
Extravasation: irritant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp,Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Dosing information

Calvert formula

  • Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989 Nov;7(11):1748-56. link to original article contains verified formula PubMed

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 3/3/1989: Initial FDA approval

Also known as

  • Code name: JM8
  • Brand names:
Synonyms
Biocarb Biocarbo Bioplatinex Biovinate Blastocarb Bonaplatin Boplatex Carbo
Carbokem Carbomedac Carbomerck Carboplat Carboplatine Carboplatino Carboplatinum Carbosin
Carbotanil Carbotec Carbotinol Careptin Carplan Carplanil Carpsol Crobextin
Cycloplatin Cycloplatinum Emorzim Erbakar Ercar Fauldcarbo Ifacap Kemocarb
Megaplatin Nealorin Neocarb Neocarbo Oncocarb Paraplatin Paraplatine Pharmaplatin
Platamine CS Platinwas Ribocarbo Tecnocarb Vancel CBDCA

References

  1. 1.0 1.1 Carboplatin (Paraplatin) package insert
  2. Carboplatin (Paraplatin) package insert (locally hosted backup)
  3. Carboplatin AUC calculator
  4. Carboplatin (Paraplatin) patient drug information (Chemocare)
  5. Carboplatin (Paraplatin) patient drug information (UpToDate)