Carboplatin (Paraplatin)

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General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.[1][2]

Route: IV
Extravasation: irritant

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp,Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Dosing information

Calvert formula

  • Calvert AH, Newell DR, Gumbrell LA, O'Reilly S, Burnell M, Boxall FE, Siddik ZH, Judson IR, Gore ME, Wiltshaw E. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol. 1989 Nov;7(11):1748-56. link to original article contains verified formula PubMed

Diseases for which it is established (work in progress)

Diseases for which it is used

Diseases for which it was used

Patient drug information

History of changes in FDA indication

  • 1989-03-03: Initial approval as palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have previously been treated with cisplatin. (Based on SWOG 8412 and Swenerton et al. 1992)

History of changes in EMA indication

  • 1986-01-23: EURD

History of changes in PMDA indication

  • 2011-11-25: New additional indication and new dosages for the treatment of breast cancer.

Also known as

  • Code name: JM-8
  • Brand names:
Biocarb Biocarbo Bioplatinex Biovinate Blastocarb Bonaplatin Boplatex Carbo
Carbokem Carbomedac Carbomerck Carboplat Carboplatine Carboplatino Carboplatinum Carbosin
Carbotanil Carbotec Carbotinol Careptin Carplan Carplanil Carpsol Crobextin
Cycloplatin Cycloplatinum Emorzim Erbakar Ercar Fauldcarbo Ifacap Kemocarb
Megaplatin Nealorin Neocarb Neocarbo Oncocarb Paraplatin Paraplatine Pharmaplatin
Platamine CS Platinwas Ribocarbo Tecnocarb Vancel CBDCA