Pomalidomide (Pomalyst)

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General information

Class/mechanism: Second-generation immunomodulatory drug (IMiD)--a thalidomide analogue--with antineoplastic activity. Pomalidomide has been shown to inhibit growth and induce apoptosis of hematopoietic tumor cells, enhance natural killer (NK) and T-cell cell-mediated immunity, and suppress monocyte production of pro-inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6).[1][2][3]

Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Kaposi sarcoma

  • 5/14/2020: Accelerated approval for adult patients with AIDS-related Kaposi sarcoma after failure of highly active antiretroviral therapy. (New disease entity with prior treatment requirement; based on NCI 12-C-0047)
  • 5/14/2020: Accelerated approval for Kaposi sarcoma in adult patients who are HIV-negative. (New disease entity; based on NCI 12-C-0047)

Multiple myeloma

  • 2/8/2013: Accelerated approval for treatment of multiple myeloma in patients who received at least two previous therapies including Lenalidomide (Revlimid) and Bortezomib (Velcade) who have progressive disease within 60 days of the completion of the last therapy. (Based on NIMBUS & CC-4047-MM-002)
    • 4/23/2015: Converted to regular approval.

Also known as

  • Code names: CC4047, CC-4047
  • Generic name: 3-amino-thalidomide
  • Brand names: Actimid, Ibipolid, Imnovid, Pomalid, Pomalyst