Lapatinib (Tykerb)

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General information

Class/mechanism: EGFR/HER2 tyrosine kinase inhibitor; 4-anilinoquinazoline inhibitor of the intracellular tyrosine kinase domains of EGFR (epidermal growth factor receptor/ErbB1) and HER2 (human epidermal growth factor receptor 2/ErbB2), which drive proliferation in certain malignancies. [1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Brand name: Tykerb


  1. 1.0 1.1 Lapatinib (Tykerb) package insert
  2. Lapatinib (Tykerb) package insert (locally hosted backup)
  3. Tykerb manufacturer's website
  4. Lapatinib (Tykerb) patient drug information
  5. Lapatinib (Tykerb) patient drug information (Chemocare)
  6. Lapatinib (Tykerb) patient drug information (UpToDate)