Ramucirumab (Cyramza)

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General information

Class/mechanism: Recombinant human IgG1 monoclonal antibody, VEGFR2 (vascular endothelial growth factor receptor 2) antagonist. Ramucirumab binds VEGFR2 and blocks VEGFR ligands, VEGF-A, VEGF-C, and VEGF-D, which inhibits angiogenesis.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code names: IMC-1121B, LY3009806
  • Brand name: Cyramza

References

  1. 1.0 1.1 1.2 Ramucirumab (Cyramza) package insert
  2. Ramucirumab (Cyramza) package insert (locally hosted backup)
  3. Cyramza manufacturer's website
  4. Ramucirumab (Cyramza) patient drug information (Chemocare)
  5. Ramucirumab (Cyramza) patient drug information (UpToDate)