Docetaxel (Taxotere)

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General information

Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.[1][2]
Route: IV
Extravasation: irritant, rare vesicant

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code names: NSC 628503, RP 56976
  • Brand names: Asodocel, Daxotel, Docegem, Doceglob, Docemax, Docenat, Docepar, Docetax, Docetec, Docetere, DoceXan, Docshil, Dolectran, Doxel, Doxetal, Hentaxel, Neocel, Oncodocel, Plustaxano, Sibatere, Taceedo, Taxe-RTU, Taxewell, Taxotere, Texot, Trixotene, Uvtere


  1. 1.0 1.1 1.2 Docetaxel (Taxotere) package insert
  2. Docetaxel (Taxotere) package insert (locally hosted backup)
  3. Docetaxel (Taxotere) patient drug information (Chemocare)
  4. Docetaxel (Taxotere) patient drug information (UpToDate)