Fotemustine (Muphoran)

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Mechanism of action

From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.

Diseases for which it is used

History of changes in EMA indication

  • 1989-04-14: EURD

Also known as

  • Brand names: Muphoran, Mustophoran