Fludarabine (Fludara)

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General information

Class/mechanism: Purine analog, antimetabolite; fludarabine is converted to the active compound, 2-fluoro-ara-ATP, which inhibits DNA synthesis by inhibiting DNA polymerase alpha, ribonucleotide reductase, and DNA primase. Relatively resistant to deamination by adenosine deaminase. The mechanism of action is not completely characterized and may be multi-faceted.[1][2]
Route: IV, PO Note: Oral fludarabine is no longer available in the US, at this time.
Extravasation: neutral

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Generic names: FAMP, fludarabine phosphate
  • Brand names: Beneflur, Fludabine, Fludara, Lymfuda, Oforta


  1. 1.0 1.1 Fludarabine (Fludara) package insert
  2. Fludarabine (Fludara) package insert (locally hosted backup)
  3. Fludarabine (Fludara) patient drug information (Chemocare)
  4. Fludarabine (Fludara) patient drug information (UpToDate)