Temsirolimus (Torisel)

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General information

Class/mechanism: mTOR (mammalian target of rapamycin) inhibitor. mTOR inhibition by temsirolimus interferes with the ability of mTOR to phosphorylate downstream targets in the PI3 kinase/AKT pathway, such as p70S6k and the S6 ribosomal protein. Temsirolimus has also been observed to reduce levels of VEGF (vascular endothelial growth factor) and hypoxia-inducible factors HIF-1 and HIF-2 alpha.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

Precise Name: temsirolimus (RXCUI 657797)

CCI 779 Torisel cell cycle inhibitor 779 rapamycin analog CCI-779


  1. 1.0 1.1 Temsirolimus (Torisel) package insert
  2. Temsirolimus (Torisel) package insert (locally hosted backup)
  3. Torisel manufacturer's website
  4. Temsirolimus (Torisel) patient drug information (Chemocare)
  5. Temsirolimus (Torisel) patient drug information (UpToDate)