Class/mechanism: PD-L1 blocking antibody. PD-L1 (programmed death-1 ligand 1) expressed on tumor cells and tumor-infiltrating immune cells can result in inhibition of anti-tumor immune responses. Durvalumab binds to PD-1 and CD80 (B7.1) receptors on T-cells and antigen presenting cells and prevents PD-L1's inhibitory effects on the immune system. As a result, durvalumab stimulates immune responses, including anti-tumor immune effects. Durvalumab is being investigated for potential use as monotherapy or in combination with tremelimumab (ticilimumab) in non-small cell lung cancer, head and neck cancer, bladder cancer, gastric cancer, pancreatic cancer, hepatocellular carcinoma, and blood cancers.
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 5/1/2017: Granted FDA accelerated approval "for the treatment of patients with locally advanced or metastatic urothelial carcinoma who:
- 2/16/2018: FDA approved "for patients with unresectable stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following concurrent platinum-based chemotherapy and radiation therapy."
Also known as
- Code name: MEDI4736
- Brand name: Imfinzi