Nintedanib (Vargatef)

Mechanism of action

From the NCI Drug Dictionary: An orally bioavailable, indolinone-derived, receptor tyrosine kinase (RTK) inhibitor with potential antiangiogenic and antineoplastic activities. Multitargeted tyrosine kinase inhibitor BIBF 1120 selectively binds to and inhibits vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR) and platelet-derived growth factor receptor (PDGFR) tyrosine kinases, which may result in the induction of endothelial cell apoptosis; a reduction in tumor vasculature; and the inhibition of tumor cell proliferation and migration. In addition, this agent also inhibits members of the Src family of tyrosine kinases, including Src, Lck, Lyn, and FLT-3 (fms-like tyrosine kinase 3).^[1]^[2]^[3]

Diseases for which it is established

Non-small cell lung cancer, nonsquamous

Diseases for which it is used

Patient drug information

History of changes in EMA indication

2014-11-21: Initial marketing authorization as Vargatef. Vargatef is indicated in combination with docetaxel for the treatment of adult patients with locally advanced, metastatic or locally recurrent non-small cell lung cancer (NSCLC) of adenocarcinoma tumour histology after first line chemotherapy. (Based on LUME-Lung 1)

Also known as

Code name: BIBF-1120
Brand names: Cyendiv, Idofnib, Nifev, Nindanib, Nintena, Nintenib, Nintib, Ofev, Vargatef

References

[insert-1] Nintedanib (Vargatef) package insert

[2] Nintedanib (Vargatef) package insert (locally hosted backup)

[3] Vargatef manufacturer's website

[4] Nintedanib (Vargatef) package insert

[5] Nintedanib (Vargatef) patient drug information (UpToDate)

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