Levels of Evidence

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The purpose of this page is to create a reference to describe our methodology for assigning levels of evidence to regimens.

Important note: Our intent is not to provide clinical decision support. Rather, our goal is to faithfully reproduce findings of clinical trials. Efficacy and toxicity information, in particular, is sometimes presented by authors in a confusing or ambivalent manner. As such, we try to illustrate ambiguities when they happen, and take no responsibility for your decision to choose a particular treatment regimen. Please read our disclaimer for further information.

Note for colorblind users: We are aware that the color scales we use are not colorblind-safe and are not compliant with Section 508. We have no current plans to change the overall coloring schema but welcome feedback on this particular point.

See the sections below for a discussion of the various metrics we use. Feedback is welcome!

Contents


Evidence

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Generally, a regimen should be evaluated in a randomized fashion with an adequate patient sample to be considered a "green" regimen. We have defined adequate as 20 or more patients per arm. Non-randomized studies and randomized studies with fewer than 20 patients per arm are considered to be "yellow" regimens. Finally, case reports, retrospective series, and non-randomized studies with fewer than 20 patients enrolled are considered to be "red" regimens. Of course, there are finer gradations of the quality of evidence so this simplified scheme should be taken with a grain of salt.

Evidence is thus reported using one of the three color-coded labels:

Strong evidence Moderate evidence Weak evidence

Wiki codes for these colors are:

style="background-color:#00cd00" style="background-color:#eeee00" style="background-color:#ff0000"

Examples

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A trial with strong evidence: R-CHOP for untreated follicular lymphoma

Study Evidence
Flinn et al. 2014 (BRIGHT) Phase III

A trial with moderate evidence: bortezomib & rituximab for untreated follicular lymphoma

Study Evidence
Evens et al. 2014 Phase II

A trial with weak evidence: cladribine for aggressive systemic mastocytosis

Study Evidence
Lim et al. 2009 Retrospective

Frequently asked questions

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Q: What is the current status of evidence labeling on hemonc.org?
A: Nearly 100% of chemotherapy regimens and their variants now have a level of evidence label.

Q: If a randomized trial has more than two arms, will they all be labeled the same?
A: No, it depends on how many patients are in each arm of the trial. For arms that have at least 20 patients, the label is green. For arms with fewer than 20, the label is yellow.

Q: Are non-randomized trials all labeled the same?
A: No, it depends on how many patients are in the trial. For trials that have at least 20 patients, the label is yellow. For trials with fewer than 20, the label is red.

Q: Some retrospective analyses are very large, will they be labeled yellow?
A: No, currently we label all retrospective analyses as red (weak evidence), no matter how large. Although we are major proponents of the secondary use of data, including automated methods of EHR data extraction, there is currently too high of a level of unknown biases and confounding to label regimens derived from retrospective data other than as weak evidence. Likewise, a trial that reports on a comparison to historic or contemporary controls not enrolled in that trial will be considered non-randomized.


Efficacy

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Defined generally, efficacy is the presence of a positive effect on the study population. Conversely, lack of efficacy is the absence of an expected positive effect, or the failure to achieve expected outcomes in adequate numbers of patients. Efficacy can be reported ranging from a weak surrogate measure (e.g., response rate) to a direct measure of overall survival. Currently, we are focusing on adding information on statistical comparative efficacy for randomized trials, and primary endpoints for non-randomized trials with >20 participants. Many non-randomized trials report efficacy compared to historical controls. However, in the rapidly developing field of oncology, this approach is rife with bias and as such we do not report on comparison to historical controls. Future work will involve reporting on effect sizes as well as statistical comparative efficacy (see Miksad et al. 2007 for a discussion of why this is important).

Non-comparative efficacy

Non-comparative efficacy is reported using a gray scale, where the lighter the color the higher the response rate. At this time, if a non-comparative trial reports a time interval as the primary endpoint (e.g., PFS), we will still report a response rate, given that time intervals can't be interpreted except as compared to historic controls (see above):

Response rate Wiki code
0% style="background-color:black; color:white"
10% style="background-color:#1a1a1a; color:white"
20% style="background-color:#333333; color:white"
30% style="background-color:#4d4d4d; color:white"
40% style="background-color:#666666; color:white"
50% style="background-color:#7f7f7f; color:white"
60% style="background-color:#999999"
70% style="background-color:#b3b3b3"
80% style="background-color:#cccccc"
90% style="background-color:#e5e5e5"
100% style="background-color:#white"

A full list of grayscale hex codes can be found here.

Comparative efficacy

Comparative efficacy is reported using a tri-color labeling (green/yellow/red), with a modifier based on statistical significance of the finding:

Superior findings

Regimens with superior comparative efficacy are labeled using a green divergent ColorBrewer scale, with intensity as a function of p-value:

Strong signal: p-value ≤ 0.01

No modifier is used, e.g., efficacy will simply be labeled as superior; e.g., superior PFS

Study Evidence Comparator Efficacy
[xx] Phase III [xx] Superior endpoint

Wiki code:

style="background-color:#1a9850"

Moderate signal: p-value > 0.01 and ≤ 0.05

The finding is modified by "seems to have"; e.g., seems to have superior PFS

Study Evidence Comparator Efficacy
[yy] Phase III [yy] Seems to have superior endpoint

Wiki code:

style="background-color:#91cf60"

Weak signal: p-value > 0.05 and ≤ 0.1

The finding is modified by "might have"; e.g., might have superior PFS

Study Evidence Comparator Efficacy
[zz] Phase III [zz] Might have superior endpoint

Wiki code:

style="background-color:#d9ef8b"

Inferior findings

Regimens with inferior comparative efficacy are labeled using a red divergent ColorBrewer scale, with intensity as a function of p-value:

Strong signal: p-value ≤ 0.01

No modifier is used, e.g., efficacy will simply be labeled as inferior; e.g., inferior OS

Study Evidence Comparator Efficacy
[xx] Phase III [xx] Inferior endpoint

Wiki code:

style="background-color:#d73027"

Moderate signal: p-value > 0.01 and ≤ 0.05

The finding is modified by "seems to have"; e.g., seems to have inferior OS

Study Evidence Comparator Efficacy
[yy] Phase III [yy] Seems to have inferior endpoint

Wiki code:

style="background-color:#fc8d59"

Weak signal: p-value > 0.05 and ≤ 0.1

The finding is modified by "might have"; e.g., might have inferior OS

Study Evidence Comparator Efficacy
[zz] Phase III [zz] Might have inferior endpoint

Wiki code:

style="background-color:#fee08b"

Negative and non-inferior findings

The distinction between a negative superiority trial and a positive non-inferiority or equivalence study is crucial. In a superiority trial, a treatment has been hypothesized to be better than another, but in the end the null hypothesis was not rejected. There is still a distinct possibility that one treatment is superior to the other (type II error), but the signal is not observed due to underpowering issues, excess crossover, attrition such that the intention-to-treat population is small, or obfuscation of a subgroup by the larger population. Non-inferiority trials use a one-sided test to determine whether a new intervention is no worse than a standard intervention. Equivalence trials have a similar design but use a two-sided test, allowing for the possibility that the new intervention is no better than the standard one. These designs require much greater numbers of participants, and are often used to evaluate a new treatment that is likely to have comparable efficacy but has an improved (or different) toxicity profile.

A "negative" superiority trial

Study Evidence Comparator Efficacy
[xx] Phase III [xx] Seems not superior

A "negative" non-inferiority trial

Study Evidence Comparator Efficacy
[yy] Phase III [yy] Inconclusive whether non-inferior

A "positive" non-inferiority trial

Study Evidence Comparator Efficacy
[zz] Phase III [zz] Non-inferior endpoint

More details

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What we are really interested in is whether efficacy findings from a clinical trial will work for our patient. As such, we have historically relied on the cutoff of p=0.05 to accept whether or not a finding is significant and true. Of course, this means that approximately 1 in 20 reportedly "true" findings are in fact falsely positive. This "holy grail" cutoff has led to significant publication bias which is well summarized by Dr. John Ioannidis in his seminal 2005 paper "Why Most Published Research Findings Are False." One potential solution is to report comparative efficacy "in plain English" as shown in the graphic below (link to original 2009 article).

Efficacy.jpg

Here is another way of considering P-values, only just a bit tongue-in-cheek from XKCD.

P values xkcd.png

Examples

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1. A treatment regimen with superior efficacy: BR for untreated follicular lymphoma

Study Evidence Comparator Efficacy
Rummel et al. 2013 (StiL NHL1) Phase III R-CHOP Superior PFS

2. A treatment regimen which failed to demonstrate a difference in primary endpoint: gemcitabine for metastatic pancreatic cancer

Study Evidence Comparator Efficacy
Hong et al. 2013 Randomized Phase II Gemcitabine & Simvastatin Seems not superior

3. A treatment regimen that is non-inferior to its comparator: capecitabine & bevacizumab for metastatic breast cancer

Study Evidence Comparator Efficacy
Zielinski et al. 2016 (TURANDOT) Phase III Paclitaxel & Bevacizumab Non-inferior OS

4. A treatment regimen with inferior efficacy: dexamethasone for relapsed/refractory multiple myeloma

Study Evidence Comparator Efficacy
Rajkumar et al. 2008 Phase III TD Inferior TTP

Frequently asked questions

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Q: What is the current status of efficacy labeling on hemonc.org?
A: All phase III trials and most randomized phase II trials are now labeled for efficacy. Future work includes labeling non-randomized trials with overall response rates (ORR).

Q: How do we choose to label efficacy when multiple outcomes are reported?
A: Often, a trial will report on multiple outcomes, such as overall response rate, progression-free survival, and overall survival. We generally look to the PRIMARY endpoint, as defined in the published methods. If the PRIMARY endpoint is negative but the trial reports a positive secondary more surrogate finding, we do NOT label this (example - primary endpoint was OS, which was not shown, but the investigational arm did have better PFS). If a secondary endpoint shows differential efficacy and is LESS "surrogate" than the primary endpoint (see below), we will label by that endpoint.

Q: How do you handle changes in efficacy when trial results are updated?
A: Many trials are published at the time of preliminary findings, and have subsequent publications as the results mature. At this time, most of these updates are added to the bibliography section of the regimen. If the strength of the efficacy assertion changes, or if a less surrogate endpoint becomes significant, we will updated the efficacy label with a (*) to denote that it is an updated efficacy.

Q: How do you distinguish between a failed superiority trial and a successful non-inferiority or equivalence study?
A: Both of them would be labeled yellow, but the language used is slightly different, and the intensity is different. Here is an example of epirubicin followed by capecitabine in the adjuvant treatment of breast cancer, where one arm failed to demonstrate superiority, whereas the other arm demonstrated statistical non-inferiority.

Study Evidence Comparator Efficacy
Cameron et al. 2017 (TACT2) Phase III Accelerated Epirubicin, then Capecitabine Seems not superior
Accelerated Epirubicin, then CMF
Epirubicin, then CMF
Non-inferior TTR

Q: Do you have a hierarchy of surrogacy?
A: Yes, we use a three-level hierarchy to determine the strength of an outcome measure: strong endpoints, intermediate surrogate endpoints, and weak surrogate endpoints. Please see the dedicated response to treatment page for more details. Note that this hierarchy is NOT used to inform the coloration of the efficacy label, at this time.

Q: What about exceptional responders?
A: It is increasingly recognized, especially with newer therapies such as immunotherapy, that some patients may experience a remarkable response to a drug that otherwise appears to lack efficacy in the population. These patients are usually referred to as "exceptional responders" and may provide significant insights into rational treatment selection a.k.a., precision medicine. At this time we do not make a particular effort to identify exceptional responders, nor do we consider a regimen for inclusion in HemOnc.org if the manuscript states that it generally lacks efficacy.

Q: Do you consider quality of life (QoL) measures in efficacy?
A: Very few RCTs report on QoL measures, and as such we do not currently include them in the consideration. This may change in the future.

Toxicity

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Defined generally, toxicity is the presence or absence of a negative effect (harm) on the study population. This is often also referred to as safety. As with efficacy, we only report comparative toxicity. Much of the focus on HemOnc.org has been on efficacy, due in large part to the fact that, while standardized, toxicity reporting tends to be limited in granularity and interpretability. We are currently taking two approaches to toxicity:

Toxicity information from the primary literature

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Due to less granular and more subjective reporting in the primary literature, toxicity is currently reported using one of three labels:

Decreased toxicity Equivalent toxicity Increased toxicity

Example

A treatment regimen with increased toxicity: R-CHOP for untreated follicular lymphoma

Study Evidence Comparator Efficacy Toxicity
Hiddemann et al. 2005 Phase III CHOP Seems to have superior OS Increased toxicity

Toxicity information from companion or post hoc analyses

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If a dedicated analysis of toxicity is performed, we will report using the standard coloring used above for efficacy. In particular, we consider health-related quality of life (HRQoL) analyses to be a rigorous surrogate of toxicity, and are actively adding these to the site.

Example

A treatment regimen with worse HRQoL: placebo for metastatic castrate-resistant prostate cancer

Study Evidence Comparator Efficacy Toxicity
Beer et al. 2014 (PREVAIL) Phase III Enzalutamide Inferior OS Worse HRQoL

Frequently asked questions

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Q: What is the current status of toxicity labeling on hemonc.org?
A: A few regimens are currently labeled for toxicity; we are focusing current efforts on labeling efficacy.

Q: Are you basing the label on the reported CTCAE measures?
A: CTCAE measures are extremely valuable in that they are structured and thus reproducible. However, it is often hard to compare them directly. For example, if one regimen has grade 4 lab-based toxicity and the other has grade 2 gastrointestinal toxicity, which is the more toxic? In general, we plan to use the authors' interpretation of overall toxicity and tolerability when labeling from primary literature - or better yet, prospectively-gathered quality-of-life data (see above).

Q: Do you plan to incorporate patient-reported outcomes?
A: As shown in numerous publications, patient reports of toxicity are more accurate than clinician assessments. However, they have not until recently been standardized. Now that the PRO-CTCAE is available, we expect to see more of these in the future and will incorporate them into the toxicity assessment.

Q: Do you plan to incorporate financial toxicity?
A: This is an incredibly important topic, and the reader is encouraged to read the publications of Dr. Yousuf Zafar for some excellent background. For now, we are focused primarily on clinical measures but are open to adding financial toxicity information.