Ipilimumab (Yervoy)

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General information

Class/mechanism: Anti-CTLA-4 antibody. CTLA-4 is a negative regulator of T-cell activation and ipilimumab interferes with the ability of CTLA-4 to interact with its ligands CD80/CD86. CTLA-4 blockade results in T-cell activation and proliferation, and it is suspected that its anti-neoplastic activity may be due to T-cell mediated anti-tumor immune responses.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code names: BMS-734016, MDX-010
  • Brand name: Yervoy


  1. 1.0 1.1 1.2 Ipilimumab (Yervoy) package insert
  2. Ipilimumab (Yervoy) package insert (locally hosted backup)
  3. Yervoy manufacturer's website
  4. YERVOY Risk Evaluation and Mitigation Strategy (REMS) Site
  5. Ipilimumab (Yervoy) patient drug information (Chemocare)
  6. Ipilimumab (Yervoy) patient drug information (UpToDate)