Trastuzumab (Herceptin)

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General information

Class/mechanism: HER2/neu receptor antagonist, humanized IgG1 kappa monoclonal antibody. Trastuzumab binds to the extracellular domain of HER2/erbB2 (human epidermal growth factor receptor 2), which is overexpressed in certain malignancies. Trastuzumab helps to mediate antibody-dependent cellular cytotoxicity (ADCC) preferentially against cells that overexpress HER2.[1][2][3]
Route: IV
Extravasation: neutral

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Brand names: Biceltis, CANMab, Herceptin, Herclon, Hertraz


  1. 1.0 1.1 Trastuzumab (Herceptin) package insert
  2. Trastuzumab (Herceptin) package insert (locally hosted backup)
  3. Herceptin manufacturer's website
  4. Trastuzumab (Herceptin) manufacturer's patient website
  5. Trastuzumab (Herceptin) patient drug information (Chemocare)
  6. Trastuzumab (Herceptin) patient drug information (UpToDate)