Class/mechanism: PD-L1 blocking antibody. PD-L1 (programmed death-1 ligand 1) expressed on tumor cells and tumor-infiltrating immune cells can result in inhibition of anti-tumor immune responses. Avelumab binds to PD-1 and B7.1 receptors on T-cells and antigen presenting cells and prevents PD-L1's inhibitory effects on the immune system. As a result, avelumab stimulates immune responses, including anti-tumor immune effects.
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 5/9/2017: Granted accelerated approval for patients with locally advanced or metastatic urothelial carcinoma whose disease progressed during or following platinum-containing chemotherapy or within 12 months of neoadjuvant or adjuvant platinum-containing chemotherapy. (New disease entity; based on JAVELIN)
- 6/30/2020: Approved for maintenance treatment of patients with locally advanced or metastatic urothelial carcinoma (UC) that has not progressed with first-line platinum-containing chemotherapy. (Converted to regular approval; expanded to maintenance setting; based on JAVELIN Bladder 100)
- 3/23/2017: Approved for the treatment of patients 12 years and older with metastatic Merkel cell carcinoma (MCC). (Initial approval; based on JAVELIN Merkel 200)
- 5/14/2019: Approved in combination with axitinib for first-line treatment of patients with advanced renal cell carcinoma (RCC). (New disease entity; based on JAVELIN Renal 101)
Also known as
- Code name: MSB0010718C
- Brand name: Bavencio