Afatinib (Gilotrif)

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General information

Class/mechanism: Irreversible tyrosine kinase inhibitor of EGFR (epidermal growth factor receptor, ErbB1), HER2 (human epidermal growth factor receptor 2, ErbB2), and HER4 (human epidermal growth factor receptor 4, ErbB4). Inhibition of tyrosine kinase autophosphorylation inhibits ErbB signaling.[1][2][3]

Route: PO
Extravasation: n/a

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

  • Code names: BIBW 2992, BIBW-2992
  • Brand names: Afanix, Gilotrif, Giotrif, Tomtovok, Tovok, Xovoltib


  1. 1.0 1.1 1.2 Afatinib (Gilotrif) package insert
  2. Afatinib (Gilotrif) package insert (locally hosted backup)
  3. Gliotrif manufacturer's website
  4. Afatinib (Gilotrif) patient drug information (Chemocare)
  5. Afatinib (Gilotrif) patient drug information (UpToDate)