Medulloblastoma

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Wayne H. Liang, MD, MS
UAB
Birmingham, AL

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3 regimens on this page
3 variants on this page


Adjuvant therapy

Carboplatin, Cyclophosphamide, Etoposide, Methotrexate, Vincristine

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Regimen

Study Evidence
Rutkowski et al. 2005 Non-randomized

Preceding treatment

Chemotherapy

References

  1. Rutkowski S, Bode U, Deinlein F, Ottensmeier H, Warmuth-Metz M, Soerensen N, Graf N, Emser A, Pietsch T, Wolff JE, Kortmann RD, Kuehl J. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med. 2005 Mar 10;352(10):978-86. link to original article PubMed

Cisplatin, Lomustine, Vincristine

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Regimen

Study Evidence Comparator Comparative Efficacy
Packer et al. 2006 Phase III (C) Cisplatin, Cyclophosphamide, Vincristine Did not meet primary endpoint of EFS

Preceding treatment

Chemotherapy

References

  1. Packer RJ, Gajjar A, Vezina G, Rorke-Adams L, Burger PC, Robertson PL, Bayer L, LaFond D, Donahue BR, Marymont MH, Muraszko K, Langston J, Sposto R. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol. 2006 Sep 1;24(25):4202-8. link to original article PubMed

Cyclophosphamide & Vincristine/Cisplatin & Etoposide

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Regimen

Study Evidence
Duffner et al. 1993 Non-randomized

Total duration of treatment is 12 to 24 months.

Preceding treatment

Chemotherapy, part 1

28-day cycle for 2 cycles, alternating with part 2

Chemotherapy, part 2

28-day cycle for 1 cycle, alternating with part 1

References

  1. Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, Sanford RA, Mulhern RK, James HE, Freeman CR, Seidel FG, Kun LE. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med. 1993 Jun 17;328(24):1725-31. link to original article PubMed