Hepatoblastoma

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Wayne H. Liang, MD, MS
UAB
Birmingham, AL

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2 regimens on this page
2 variants on this page


All lines of therapy

Cisplatin monotherapy

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Regimen

Study Evidence Comparator Comparative Efficacy
Perilongo et al. 2009 (SIOPEL 3) Phase III (E-de-esc) Cisplatin & Doxorubicin Non-inferior complete resection rate

Chemotherapy

References

  1. SIOPEL 3: Perilongo G, Maibach R, Shafford E, Brugieres L, Brock P, Morland B, de Camargo B, Zsiros J, Roebuck D, Zimmermann A, Aronson D, Childs M, Widing E, Laithier V, Plaschkes J, Pritchard J, Scopinaro M, MacKinlay G, Czauderna P. Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. N Engl J Med. 2009 Oct 22;361(17):1662-70. link to original article PubMed

Cisplatin & Doxorubicin

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PLADO: PLAtinol (Cisplatin) & DOxorubicin

Regimen

Study Evidence Comparator Comparative Efficacy Comparative Toxicity
Ortega et al. 2000 Phase III (E-switch-ic) Cisplatin, 5-FU, Vincristine More toxic
Perilongo et al. 2009 (SIOPEL 3) Phase III (C) Cisplatin Non-inferior complete resection rate

Chemotherapy

References

  1. Ortega JA, Douglass EC, Feusner JH, Reynolds M, Quinn JJ, Finegold MJ, Haas JE, King DR, Liu-Mares W, Sensel MG, Krailo MD. Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: a report from the Children's Cancer Group and the Pediatric Oncology Group. J Clin Oncol. 2000 Jul;18(14):2665-75. link to original article PubMed
  2. SIOPEL 3: Perilongo G, Maibach R, Shafford E, Brugieres L, Brock P, Morland B, de Camargo B, Zsiros J, Roebuck D, Zimmermann A, Aronson D, Childs M, Widing E, Laithier V, Plaschkes J, Pritchard J, Scopinaro M, MacKinlay G, Czauderna P. Cisplatin versus cisplatin plus doxorubicin for standard-risk hepatoblastoma. N Engl J Med. 2009 Oct 22;361(17):1662-70. link to original article PubMed