How I Treat

From - A Hematology Oncology Wiki
Jump to navigation Jump to search

The "How I Treat" series has been published by Blood for several decades and covers a wide variety of topics in malignant and classical hematology. While these articles are not considered to be formal guidelines, they are considered highly reputable sources of expert opinion. They cover topics ranging from commonly encountered hematologic conditions with a large evidence base, to very rare conditions with only case reports to guide treatment. The purpose of this page is to consolidate the links to all known published How I Treat articles.

In the first two sections (malignant hematology and classical hematology), articles are presented by condition, in reverse chronological order. In the third section, articles are gathered under "special considerations" such as pregnancy and hematologic disease. The fourth section contains miscellaneous topics that do not easily fit into the above categories. Given the rapid change in evidence in many areas of hematology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.

Malignant hematology

Acute leukemias

Mixed-phenotype acute leukemia (MPAL)

Myeloid neoplasms

Acute lymphoblastic leukemia (ALL)

Acute myeloid leukemia (AML)

Acute promyelocytic leukemia (APL)

Chronic myeloid leukemia (CML)

Chronic myelomonocytic leukemia (CMML)

Hypereosinophilic syndrome (HES)

Myelodysplastic syndrome (MDS)

Myeloproliferative neoplasms (MPNs)

Essential thrombocythemia (ET)

Myelofibrosis (MF)

Polycythemia vera (PV)

Systemic mastocytosis

Lymphoid neoplasms

Adult T-cell leukemia-lymphoma (ATLL)

Anaplastic large cell lymphoma

Burkitt lymphoma (BL)

Castleman disease

Chronic lymphocytic leukemia (CLL/SLL)

Classical Hodgkin lymphoma (cHL)

CNS lymphoma

Cutaneous T-cell lymphoma (CTCL)

Diffuse large B-cell lymphoma (DLBCL)

Follicular lymphoma (FL)

High-grade B-cell lymphoma (HGBL)

HIV-associated lymphoma

Large granular lymphocytic leukemia (T-LGL)

Mantle cell lymphoma (MCL)

NK- and T-cell lymphoma (NKTCL)

Nodular lymphocyte-predominant Hodgkin lymphoma (NLP-HL)

Peripheral T-cell lymphoma (PTCL)

Post-transplant lymphoproliferative disorder (PTLD)

Primary mediastinal B-cell lymphoma (PMBCL)

Prolymphocytic leukemia (T-PLL)

Splenic lymphoma

Transformed lymphoma

Waldenström macroglobulinemia (WM)

Plasma cell dyscrasias

Light-chain (AL) amyloidosis


Multiple myeloma (MM)

Plasma cell leukemia (PCL)

Smoldering multiple myeloma (SMM)

Histiocytic disorders

Hemophagocytic lymphohistiocytosis (HLH)

Langerhans cell histiocytosis (LCH)

Classical hematology

Hemostasis and thrombosis

Acquired thrombotic thrombocytopenic purpura (aTTP)

Antiphospholipid antibody syndrome (APS)

Arterial thromboembolism (ATE)

Disseminated intravascular coagulation (DIC)


Heparin-induced thrombocytopenia (HIT)

Thrombotic microangiopathy (TMA)

Venous thromboembolism (VTE)

von Willebrand disease (vWD)


Acquired pure red cell aplasia


Aplastic anemia

Autoimmune cytopenia

Immune thrombocytopenia (ITP)

Neutropenia & leukopenia

Thrombocytopenia and platelet dysfunction

WHIM syndrome


Beta thalassemia

Sickle cell disease

Hemolytic disorders

Cold agglutinin disease (CAD)

Atypical hemolytic uremic syndrome (aHUS)

Paroxysmal nocturnal hemoglobinuria (PNH)

Warm autoimmune hemolytic anemia (WAIHA)

Special considerations

Age-based recommendations

The majority of How I Treat articles focus on "standard" adults; below, articles that focus on other age populations are concatenated.



Adolescents and young adults (AYA)

Older adults/Geriatric hematology

Complications of treatment


Cardiovascular complications

Immune effector cells toxicity management

Infectious complications

Iron overload

Medication toxicities

Neurologic medications

Genetic risk

Gynecologic considerations



Postpartum period


Regional considerations

Surgical considerations


Allogeneic HSCT

Autologous HSCT

Graft versus host disease (GVHD)


Atrial fibrillation



Common variable immune deficiency (CVID)

Severe combined immunodeficiency (SCID)



T-cell chronic active Epstein-Barr virus disease (CAEBV)