Thrombocytopenia and platelet dysfunction

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Definition of thrombocytopenia

Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.


May consist of:

  • CBC with differential
  • Comprehensive metabolic panel, including liver function tests (LFTs)
  • Vitamin B12
  • Folate
  • Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
  • Peripheral smear, platelet clumps
  • Clinical history (bleeding, temporality, recent infections), TTP/aHUS
  • Thrombotic history (e.g., heparin/HIT)
  • Lifestyle factors (e.g. alcohol)
  • Medications
  • Hepatitis serologies
  • HIV
  • ANA, lupus
  • Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
  • Pregnancy/gestational thrombocytopenia
  • ITP

Relevant diagnoses