WHIM syndrome

Section editor
	Benjamin Tillman, MD Vanderbilt University Nashville, TN, USA LinkedIn

WHIM: Warts, Hypogammaglobulinemia, Infections, Myelokathexis

1 regimens on this page 1 variants on this page

All lines of therapy

Plerixafor monotherapy

Regimen

Study	Dates of enrollment	Evidence
McDermott et al. 2019	Not reported	Pilot, fewer than 20 pts

Growth factor therapy

• Plerixafor (Mozobil) 0.01 to 0.02 mg/kg SC twice per day

Various durations

References

1. Case series: McDermott DH, Pastrana DV, Calvo KR, Pittaluga S, Velez D, Cho E, Liu Q, Trout HH 3rd, Neves JF, Gardner PJ, Bianchi DA, Blair EA, Landon EM, Silva SL, Buck CB, Murphy PM. Plerixafor for the treatment of WHIM syndrome. N Engl J Med. 2019 Jan 10;380(2):163-170. link to original article link to PMC article dosing details in manuscript have been reviewed by our editors PubMed