Cyclophosphamide (Cytoxan)

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.^[1]^[2]
Route: IV, PO
Extravasation: irritant or neutral, depending on reference; n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

11/16/1959: initial FDA approval

Also known as

Code names: Asta B 518, B-518, WR-138719
Generic names: CP monohydrate, CPM, cyclophosphamid monohydrate, cyclophosphamide monohydrate
Brand names:

Synonyms
Alkyloxan	Biodoxan	Carloxan	Ciclofosfamida	Ciclokebir	Cicloxal	Clafen	Claphene
Cyclam	Cycloblastin	Cycloblastine	CYCLO-cell	Cycloferon	Cyclomide	Cyclophar	Cyclophospham
Cyclophosphamid	Cyclophosphane	Cyclostin	Cyclostine	Cyclotox	Cycloxan	Cycram	Cydoxan
Cyklofosfamid	Cyphos	Cytophosphan	Cytoxan	Cytoxan Lyophilized	Endoxan	Endoxan-N	Endoxana
Enduxan	Formitex	Fosfaseron	Genoxal	Genuxal	Hidrofosmin	Ledoxan	Ledoxina
Mitoxan	Neophos	Neosar	Oncomide	Oncophos	Procytox	Revimmune	Sendoxan
Siklofos	Syklofosfamid	Tymtran	Zuviphos	Zycram	Zytoxan

References

[insert-1] 1.0 ^1.1 ^1.2 Cyclophosphamide (Cytoxan) package insert

[2] Cyclophosphamide (Cytoxan) package insert (locally hosted backup)

[3] Cyclophosphamide (Cytoxan) patient drug information (Chemocare)

[4] Cyclophosphamide (Cytoxan) patient drug information (UpToDate)

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