Vincristine (Oncovin)

General information

Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.^[1]^[2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Diseases for which it was used

Breast cancer

Notable side effects

Neuropathy ^[3]

Patient drug information

History of changes in FDA indication

7/10/1963: Initial FDA approval

Also known as

Synonyms
Alcrist	Biocrist	Biocrystin	Cellcristin	Citomid	Crivosin	Cytomid	Farmistin CS
Fauldvincri	Krebin	Kyocristine	Nevexitin	Onkocristin	Pericristine	Pharmacristine	Tecnocris
Vincasar	Vinces	Vincosid	Vincran	Vincrex	Vincrifil	Vincrin	Vincrisin
Vincrisol	Vincristin	Vincristina	Vincristinesulfaat	Vincristinsulfat	Vincristinum	Vincrisul	Vinracin
Vinracine	Vinstin	Vintec

References

↑ ^1.0 ^1.1 Vincristine (Oncovin) package insert
↑ Vincristine (Oncovin) package insert (locally hosted backup)
↑ Broyl A, Corthals SL, Jongen JL, van der Holt B, Kuiper R, de Knegt Y, van Duin M, el Jarari L, Bertsch U, Lokhorst HM, Durie BG, Goldschmidt H, Sonneveld P. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21. link to original article contains verified protocol PubMed
↑ Vincristine (Oncovin) patient drug information (Chemocare)
↑ Vincristine (Oncovin) patient drug information (UpToDate)

[insert-1] 1.0 ^1.1 Vincristine (Oncovin) package insert

[2] Vincristine (Oncovin) package insert (locally hosted backup)

[3] Broyl A, Corthals SL, Jongen JL, van der Holt B, Kuiper R, de Knegt Y, van Duin M, el Jarari L, Bertsch U, Lokhorst HM, Durie BG, Goldschmidt H, Sonneveld P. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21. link to original article contains verified protocol PubMed

[4] Vincristine (Oncovin) patient drug information (Chemocare)

[5] Vincristine (Oncovin) patient drug information (UpToDate)

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