Vascular sarcoma

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Elizabeth J. Davis, MD
Vanderbilt University
Nashville, TN

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2 regimens on this page
2 variants on this page
  • Note: this page contains regimens for several subtypes of vascular sarcoma. The following links will take you to disease-specific pages:
  • Regimens for Kaposi sarcoma are here.


Guidelines

ESMO

NCCN

Angiosarcoma, all lines of therapy

Bevacizumab monotherapy

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Regimen

Study Evidence
Agulnik et al. 2013 Phase II

Targeted therapy

21-day cycles

References

  1. Agulnik M, Yarber JL, Okuno SH, von Mehren M, Jovanovic BD, Brockstein BE, Evens AM, Benjamin RS. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013 Jan;24(1):257-63. link to original article contains verified protocol PubMed

Paclitaxel monotherapy

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Regimen

Study Evidence
Penel et al. 2008 (ANGIOTAX) Phase II

Chemotherapy

Supportive medications

28-day cycle for 6 cycles

References

  1. ANGIOTAX: Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol. 2008 Nov 10;26(32):5269-74. Epub 2008 Sep 22. link to original article contains verified protocol PubMed

Hemangioendothelioma, all lines of therapy

Hemangiopericytoma (solitary fibrous tumor), all lines of therapy