Vulvar cancer

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Dewdney.jpg
Summer B. Dewdney, MD
Rush University
Chicago, IL
2 regimens on this page
2 variants on this page


Guidelines

NCCN

Neoadjuvant therapy

Cisplatin & RT

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RT: Radiation Therapy

Regimen

Study Evidence
Moore et al. 2011 Phase II

Chemotherapy

Radiotherapy

6.5-week course

Subsequent treatment

References

  1. Moore DH, Ali S, Koh WJ, Michael H, Barnes MN, McCourt CK, Homesley HD, Walker JL. A phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva: a Gynecologic Oncology Group study. Gynecol Oncol. 2012 Mar;124(3):529-33. Epub 2011 Nov 9. link to original article contains protocol PubMed

Locally advanced or metastatic disease

Due to its relative rarity, there are very few prospective trials in advanced and metastatic vulvar cancer. In clinical practice, many adopt regimens from the cervical cancer literature; see the cervical cancer page for those regimens.

Paclitaxel monotherapy

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Regimen

Study Evidence
Witteveen et al. 2009 Phase II

Chemotherapy

21-day cycle for up to 10 cycles

References

  1. Witteveen PO, van der Velden J, Vergote I, Guerra C, Scarabeli C, Coens C, Demonty G, Reed N. Phase II study on paclitaxel in patients with recurrent, metastatic or locally advanced vulvar cancer not amenable to surgery or radiotherapy: a study of the EORTC-GCG (European Organisation for Research and Treatment of Cancer--Gynaecological Cancer Group). Ann Oncol. 2009 Sep;20(9):1511-6. Epub 2009 Jun 1. link to original article link to PMC article contains verified protocol PubMed