Cyclophosphamide (Cytoxan)

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.^[1]^[2]
Route: IV, PO
Extravasation: irritant or neutral, depending on reference; n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

11/16/1959: initial FDA approval

Also known as

Synonyms
Alkyloxan	Biodoxan	Carloxan	Ciclofosfamida	Ciclofosfamida Filaxis	Ciclofosfamida Martian	Ciclokebir	Cyclam
Cycloblastin	Cycloblastine	Cyclo Cell	Cycloferon	Cyclomide	Cyclophar	Cyclophospham	Cyclophosphamid
cyclophosphamide monohydrate	Cyclophosphamid Farmos	Cyclophosphan	Cyclophosphan Lens	Cyclostin	Cycloxan	Cycram	Cydoxan
Cyklofosfamid	Cytophosphan	Cytoxan	Cytoxan Lyophilized	Endoxan	Endoxan-N	Endoxana	Endoxan Asta
Formitex	Genoxal	Genuxal	Hidrofosmin	Ledoxan	Ledoxina	Lyophilized Cytoxan	Neosar
Oncomide	Oncophos	Procytox	Revimmune	Sendoxan	Syklofosfamid	Trav Cyclophosphamide	Tymtran
Zycram

References

[insert-1] 1.0 ^1.1 Cyclophosphamide (Cytoxan) package insert

[2] Cyclophosphamide (Cytoxan) package insert (locally hosted backup)

[3] Cyclophosphamide (Cytoxan) patient drug information (Chemocare)

[4] Cyclophosphamide (Cytoxan) patient drug information (UpToDate)

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