Bone sarcoma

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1 regimens on this page
1 variants on this page


Note: this page is a gathering place for the 10+ subtypes of bone sarcoma. Subtypes with substantial numbers of regimens will be moved to their own pages, with links preserved here.

Guidelines

ESMO

NCCN

Chondrosarcoma, all lines of therapy

Ewing's sarcoma, all lines of therapy

Giant-cell tumor of bone, all lines of therapy

Denosumab monotherapy

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Regimen

Study Evidence
Thomas et. al 2010 Phase II

Primary therapy

  • Denosumab (Xgeva) as follows:
    • Cycle 1: 120 mg SC once per day on days 1, 8, 15
    • Cycle 2 onwards: 120 mg SC once on day 1

Supportive medications

  • Calcium 500 mg PO once per day
  • Vitamin D 400 IU PO once per day

28-day cycles, given until complete tumor resection, progression of disease, or patient choice

References

  1. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010 Mar;11(3):275-80. link to original article contains verified protocol PubMed

Malignant fibrous histiocytoma (MFH) of bone, all lines of therapy

Osteosarcoma, all lines of therapy