Difference between revisions of "Cyclophosphamide (Cytoxan)"

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==Diseases for which it is used==
 
==Diseases for which it is used==
 
<div style="column-count:3;-moz-column-count:3;-webkit-column-count:3">
 
<div style="column-count:3;-moz-column-count:3;-webkit-column-count:3">
−
*[[Acute lymphocytic leukemia]]
 
 
*[[Adult T-cell leukemia-lymphoma]]
 
*[[Adult T-cell leukemia-lymphoma]]
 
*[[Anaplastic large cell lymphoma]]
 
*[[Anaplastic large cell lymphoma]]
 +
*[[B-cell acute lymphoblastic leukemia]]
 
*[[Bladder cancer]]
 
*[[Bladder cancer]]
 
*[[Bone cancer]]  
 
*[[Bone cancer]]  
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*[[Coagulopathies]]
 
*[[Coagulopathies]]
 
*[[Diffuse large B-cell lymphoma]]
 
*[[Diffuse large B-cell lymphoma]]
 +
*[[Ewing's sarcoma]]
 
*[[Follicular lymphoma]]
 
*[[Follicular lymphoma]]
 +
*[[Glioblastoma]]
 
*[[HIV-associated lymphoma]]
 
*[[HIV-associated lymphoma]]
 
*[[Hodgkin lymphoma]]
 
*[[Hodgkin lymphoma]]
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*[[Multiple myeloma]]
 
*[[Multiple myeloma]]
 
*[[Neuroendocrine tumors]]
 
*[[Neuroendocrine tumors]]
 +
*[[Osteosarcoma]]
 
*[[Peripheral T-cell lymphoma]]
 
*[[Peripheral T-cell lymphoma]]
 
*[[Plasma cell leukemia]]
 
*[[Plasma cell leukemia]]
 +
*[[Post-transplant lymphoproliferative disorder]]
 
*[[Primary mediastinal B-cell lymphoma]]
 
*[[Primary mediastinal B-cell lymphoma]]
 
*[[Prostate cancer]]
 
*[[Prostate cancer]]
 
*[[Small cell lung cancer]]
 
*[[Small cell lung cancer]]
 +
*[[T-cell acute lymphoblastic leukemia]]
 
*[[Thymoma]]
 
*[[Thymoma]]
 
*[[Transformed lymphoma]]
 
*[[Transformed lymphoma]]
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[[Category:Nitrogen mustards]]
 
[[Category:Nitrogen mustards]]
  
−
[[Category:Acute lymphocytic leukemia medications]]
 
 
[[Category:Adult T-cell leukemia-lymphoma medications]]
 
[[Category:Adult T-cell leukemia-lymphoma medications]]
 
[[Category:Anaplastic large cell lymphoma medications]]
 
[[Category:Anaplastic large cell lymphoma medications]]
 +
[[Category:B-cell acute lymphoblastic leukemia medications]]
 
[[Category:Bladder cancer medications]]
 
[[Category:Bladder cancer medications]]
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
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[[Category:Coagulopathy medications]]
 
[[Category:Coagulopathy medications]]
 
[[Category:Diffuse large B-cell lymphoma medications]]
 
[[Category:Diffuse large B-cell lymphoma medications]]
 +
[[Category:Ewing's sarcoma medications]]
 
[[Category:Follicular lymphoma medications]]
 
[[Category:Follicular lymphoma medications]]
 +
[[Category:Glioblastoma medications]]
 
[[Category:HIV-associated lymphoma medications]]
 
[[Category:HIV-associated lymphoma medications]]
 
[[Category:Hodgkin lymphoma medications]]
 
[[Category:Hodgkin lymphoma medications]]
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[[Category:Multiple myeloma medications]]
 
[[Category:Multiple myeloma medications]]
 
[[Category:Neuroendocrine tumor medications]]
 
[[Category:Neuroendocrine tumor medications]]
 +
[[Category:Osteosarcoma medications]]
 
[[Category:Peripheral T-cell lymphoma medications]]
 
[[Category:Peripheral T-cell lymphoma medications]]
 
[[Category:Plasma cell leukemia medications]]
 
[[Category:Plasma cell leukemia medications]]
 +
[[Category:Post-transplant lymphoproliferative disorder medications]]
 
[[Category:Primary mediastinal B-cell lymphoma medications]]
 
[[Category:Primary mediastinal B-cell lymphoma medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Prostate cancer medications]]
 
[[Category:Small cell lung cancer medications]]
 
[[Category:Small cell lung cancer medications]]
−
[[Category:T-cell lymphoma medications]]
+
[[Category:T-cell acute lymphoblastic leukemia medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Transformed lymphoma medications]]
 
[[Category:Transformed lymphoma medications]]

Revision as of 13:09, 21 July 2017

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.[1][2]
Route: IV, PO
Extravasation: irritant or neutral, depending on reference; n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 11/16/1959: initial FDA approval

Also known as

Synonyms
Alkyloxan Biodoxan Carloxan Ciclofosfamida Ciclofosfamida Filaxis Ciclofosfamida Martian Ciclokebir Cyclam
Cycloblastin Cycloblastine Cyclo Cell Cycloferon Cyclomide Cyclophar Cyclophospham Cyclophosphamid
cyclophosphamide monohydrate Cyclophosphamid Farmos Cyclophosphan Cyclophosphan Lens Cyclostin Cycloxan Cycram Cydoxan
Cyklofosfamid Cytophosphan Cytoxan Cytoxan Lyophilized Endoxan Endoxan-N Endoxana Endoxan Asta
Formitex Genoxal Genuxal Hidrofosmin Ledoxan Ledoxina Lyophilized Cytoxan Neosar
Oncomide Oncophos Procytox Revimmune Sendoxan Syklofosfamid Trav Cyclophosphamide Tymtran
Zycram

References

  1. ↑ 1.0 1.1 Cyclophosphamide (Cytoxan) package insert
  2. ↑ Cyclophosphamide (Cytoxan) package insert (locally hosted backup)
  3. ↑ Cyclophosphamide (Cytoxan) patient drug information (Chemocare)
  4. ↑ Cyclophosphamide (Cytoxan) patient drug information (UpToDate)
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