Difference between revisions of "Endometrial cancer"
m |
(added regimen & variant labels) |
||
Line 3: | Line 3: | ||
Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are [[How_to_contribute|invited to contribute to the site]]. | Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are [[How_to_contribute|invited to contribute to the site]]. | ||
+ | {| class="wikitable" style="float:right; margin-right: 5px;" | ||
+ | |- | ||
+ | |<div style="background-color: #66FF66; border: 1px solid #808000; padding: 5px; {{border-radius|16px}}" align="right"><font size="4"><b>{{#ask: [[-Has subobject::{{FULLPAGENAME}}]] |?Regimen |limit=10000|format=sum}} regimens on this page</b></font></div> | ||
+ | <div style="background-color: #66CCFF; border: 1px solid #808000; padding: 5px; {{border-radius|16px}}"><font size="4"><b>{{#ask: [[-Has subobject::{{FULLPAGENAME}}]] |?Variant |limit=10000|format=sum}} variants on this page</b></font></div> | ||
+ | |} | ||
{{TOC limit|limit=3}} | {{TOC limit|limit=3}} | ||
=Hormone therapy for endometrioid histologies= | =Hormone therapy for endometrioid histologies= | ||
− | ==Anastrozole (Arimidex)== | + | ==Anastrozole (Arimidex) {{#subobject:534a|Regimen=1}}== |
+ | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 22: | Line 31: | ||
# Rose PG, Brunetto VL, VanLe L, Bell J, Walker JL, Lee RB. A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2000 Aug;78(2):212-6. [http://www.sciencedirect.com/science/article/pii/S0090825800958657 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10926805 PubMed] | # Rose PG, Brunetto VL, VanLe L, Bell J, Walker JL, Lee RB. A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2000 Aug;78(2):212-6. [http://www.sciencedirect.com/science/article/pii/S0090825800958657 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10926805 PubMed] | ||
− | ==Medroxyprogesterone acetate (MPA)== | + | ==Medroxyprogesterone acetate (MPA) {{#subobject:6c7bb9|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:8b5e67|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 39: | Line 52: | ||
# Thigpen JT, Brady MF, Alvarez RD, Adelson MD, Homesley HD, Manetta A, Soper JT, Given FT. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol. 1999 Jun;17(6):1736-44. [http://jco.ascopubs.org/content/17/6/1736.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10561210 PubMed] | # Thigpen JT, Brady MF, Alvarez RD, Adelson MD, Homesley HD, Manetta A, Soper JT, Given FT. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol. 1999 Jun;17(6):1736-44. [http://jco.ascopubs.org/content/17/6/1736.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10561210 PubMed] | ||
− | ==Medroxyprogesterone acetate & Tamoxifen== | + | ==Medroxyprogesterone acetate & Tamoxifen {{#subobject:60584d|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:334b8c|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 57: | Line 74: | ||
# Whitney CW, Brunetto VL, Zaino RJ, Lentz SS, Sorosky J, Armstrong DK, Lee RB; Gynecologic Oncology Group study. Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004 Jan;92(1):4-9. [http://www.sciencedirect.com/science/article/pii/S0090825803006516 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/14751130 PubMed] | # Whitney CW, Brunetto VL, Zaino RJ, Lentz SS, Sorosky J, Armstrong DK, Lee RB; Gynecologic Oncology Group study. Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004 Jan;92(1):4-9. [http://www.sciencedirect.com/science/article/pii/S0090825803006516 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/14751130 PubMed] | ||
− | ==Megestrol acetate (Megace)== | + | ==Megestrol acetate (Megace) {{#subobject:4b50ea|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:52dc53|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 74: | Line 95: | ||
# Pandya KJ, Yeap BY, Weiner LM, Krook JE, Erban JK, Schinella RA, Davis TE. Megestrol and tamoxifen in patients with advanced endometrial cancer: an Eastern Cooperative Oncology Group Study (E4882). Am J Clin Oncol. 2001 Feb;24(1):43-6. [http://journals.lww.com/amjclinicaloncology/Fulltext/2001/02000/Megestrol_and_Tamoxifen_in_Patients_With_Advanced.7.aspx link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/11232948 PubMed] | # Pandya KJ, Yeap BY, Weiner LM, Krook JE, Erban JK, Schinella RA, Davis TE. Megestrol and tamoxifen in patients with advanced endometrial cancer: an Eastern Cooperative Oncology Group Study (E4882). Am J Clin Oncol. 2001 Feb;24(1):43-6. [http://journals.lww.com/amjclinicaloncology/Fulltext/2001/02000/Megestrol_and_Tamoxifen_in_Patients_With_Advanced.7.aspx link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/11232948 PubMed] | ||
− | ==Megestrol acetate & Tamoxifen== | + | ==Megestrol acetate & Tamoxifen {{#subobject:f03c30|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:4e79f7|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 93: | Line 118: | ||
# Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W; Gynecologic Oncology Group study. Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004 Jan;92(1):10-4. [http://www.sciencedirect.com/science/article/pii/S009082580300787X link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/14751131 PubMed] | # Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W; Gynecologic Oncology Group study. Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004 Jan;92(1):10-4. [http://www.sciencedirect.com/science/article/pii/S009082580300787X link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/14751131 PubMed] | ||
− | ==Tamoxifen (Nolvadex)== | + | ==Tamoxifen (Nolvadex) {{#subobject:ab84a1|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:af71e3|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 112: | Line 141: | ||
=Adjuvant radiation & chemotherapy= | =Adjuvant radiation & chemotherapy= | ||
− | ==Cisplatin, Doxorubicin, RT== | + | ==Cisplatin, Doxorubicin, RT {{#subobject:4d10f0|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:ef532f|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 143: | Line 176: | ||
# Homesley HD, Filiaci V, Gibbons SK, Long HJ, Cella D, Spirtos NM, Morris RT, DeGeest K, Lee R, Montag A. A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study. Gynecol Oncol. 2009 Mar;112(3):543-52. Epub 2008 Dec 23. [http://www.sciencedirect.com/science/article/pii/S0090825808009384 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/19108877 PubMed] | # Homesley HD, Filiaci V, Gibbons SK, Long HJ, Cella D, Spirtos NM, Morris RT, DeGeest K, Lee R, Montag A. A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study. Gynecol Oncol. 2009 Mar;112(3):543-52. Epub 2008 Dec 23. [http://www.sciencedirect.com/science/article/pii/S0090825808009384 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/19108877 PubMed] | ||
− | ==Cisplatin, Doxorubicin, Paclitaxel, RT== | + | ==Cisplatin, Doxorubicin, Paclitaxel, RT {{#subobject:24a846|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:3c5317|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 176: | Line 213: | ||
=Advanced, recurrent, or metastatic disease= | =Advanced, recurrent, or metastatic disease= | ||
− | ==Bevacizumab (Avastin)== | + | ==Bevacizumab (Avastin) {{#subobject:b29ce2|Regimen=1}}== |
− | ===Regimen, Aghajanian et al. 2011=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen, Aghajanian et al. 2011 {{#subobject:8159f4|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 193: | Line 234: | ||
# Aghajanian C, Sill MW, Darcy KM, Greer B, McMeekin DS, Rose PG, Rotmensch J, Barnes MN, Hanjani P, Leslie KK. Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2011 Jun 1;29(16):2259-65. doi: 10.1200/JCO.2010.32.6397. Epub 2011 May 2. [http://jco.ascopubs.org/content/29/16/2259.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/21537039 PubMed] | # Aghajanian C, Sill MW, Darcy KM, Greer B, McMeekin DS, Rose PG, Rotmensch J, Barnes MN, Hanjani P, Leslie KK. Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2011 Jun 1;29(16):2259-65. doi: 10.1200/JCO.2010.32.6397. Epub 2011 May 2. [http://jco.ascopubs.org/content/29/16/2259.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/21537039 PubMed] | ||
− | ==Carboplatin (Paraplatin)== | + | ==Carboplatin (Paraplatin) {{#subobject:f9b8ad|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:6a2df1|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 211: | Line 256: | ||
# van Wijk FH, Lhommé C, Bolis G, Scotto di Palumbo V, Tumolo S, Nooij M, de Oliveira CF, Vermorken JB; European Organization for Research and Treatment of Cancer. Gynaecological Cancer Group. Phase II study of carboplatin in patients with advanced or recurrent endometrial carcinoma. A trial of the EORTC Gynaecological Cancer Group. Eur J Cancer. 2003 Jan;39(1):78-85. [http://www.ejcancer.info/article/S0959-8049%2802%2900504-X/abstract link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/12504662 PubMed] | # van Wijk FH, Lhommé C, Bolis G, Scotto di Palumbo V, Tumolo S, Nooij M, de Oliveira CF, Vermorken JB; European Organization for Research and Treatment of Cancer. Gynaecological Cancer Group. Phase II study of carboplatin in patients with advanced or recurrent endometrial carcinoma. A trial of the EORTC Gynaecological Cancer Group. Eur J Cancer. 2003 Jan;39(1):78-85. [http://www.ejcancer.info/article/S0959-8049%2802%2900504-X/abstract link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/12504662 PubMed] | ||
− | ==Carboplatin & Doxorubicin liposomal== | + | ==Carboplatin & Doxorubicin liposomal {{#subobject:c8ff00|Regimen=1}}== |
− | ===Regimen, Pignata et al. 2007 (END-1)=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen, Pignata et al. 2007 (END-1) {{#subobject:d48f39|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 232: | Line 281: | ||
# Pignata S, Scambia G, Pisano C, Breda E, Di Maio M, Greggi S, Ferrandina G, Lorusso D, Zagonel V, Febbraro A, Riva N, De Rosa V, Gallo C, Perrone F; Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies Group. A multicentre phase II study of carboplatin plus pegylated liposomal doxorubicin as first-line chemotherapy for patients with advanced or recurrent endometrial carcinoma: the END-1 study of the MITO (Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies) group. Br J Cancer. 2007 Jun 4;96(11):1639-43. Epub 2007 May 8. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359926/ link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17486128 PubMed] | # Pignata S, Scambia G, Pisano C, Breda E, Di Maio M, Greggi S, Ferrandina G, Lorusso D, Zagonel V, Febbraro A, Riva N, De Rosa V, Gallo C, Perrone F; Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies Group. A multicentre phase II study of carboplatin plus pegylated liposomal doxorubicin as first-line chemotherapy for patients with advanced or recurrent endometrial carcinoma: the END-1 study of the MITO (Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies) group. Br J Cancer. 2007 Jun 4;96(11):1639-43. Epub 2007 May 8. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2359926/ link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17486128 PubMed] | ||
− | ==Carboplatin & Paclitaxel== | + | ==Carboplatin & Paclitaxel {{#subobject:b0e21f|Regimen=1}}== |
− | ===Regimen #1, Pectasides et al. 2008=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen #1, Pectasides et al. 2008 {{#subobject:7ab5c0|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 247: | Line 300: | ||
'''21-day cycles x 6 to 9 cycles''' | '''21-day cycles x 6 to 9 cycles''' | ||
− | ===Regimen #2, Hoskins et al. 2001 & Shechter-Maor et al. 2008=== | + | ===Regimen #2, Hoskins et al. 2001 & Shechter-Maor et al. 2008 {{#subobject:3a58ce|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 261: | Line 314: | ||
'''21-day cycles''' | '''21-day cycles''' | ||
− | ===Regimen #3, Sorbe et al. 2008=== | + | ===Regimen #3, Sorbe et al. 2008 {{#subobject:100919|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 281: | Line 334: | ||
# '''Retrospective:''' Shechter-Maor G, Bruchim I, Ben-Harim Z, Altaras M, Fishman A. Combined chemotherapy regimen of carboplatin and paclitaxel as adjuvant treatment for papillary serous and clear cell endometrial cancer. Int J Gynecol Cancer. 2009 May;19(4):662-4. [http://journals.lww.com/ijgc/pages/articleviewer.aspx?year=2009&issue=05000&article=00029&type=abstract link to original article] [http://www.ncbi.nlm.nih.gov/pubmed/19509567 PubMed] | # '''Retrospective:''' Shechter-Maor G, Bruchim I, Ben-Harim Z, Altaras M, Fishman A. Combined chemotherapy regimen of carboplatin and paclitaxel as adjuvant treatment for papillary serous and clear cell endometrial cancer. Int J Gynecol Cancer. 2009 May;19(4):662-4. [http://journals.lww.com/ijgc/pages/articleviewer.aspx?year=2009&issue=05000&article=00029&type=abstract link to original article] [http://www.ncbi.nlm.nih.gov/pubmed/19509567 PubMed] | ||
− | ==Cisplatin & Doxorubicin== | + | ==Cisplatin & Doxorubicin {{#subobject:7f9e48|Regimen=1}}== |
− | ===Regimen #1, Fleming et al. 2004=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen #1, Fleming et al. 2004 {{#subobject:1748e2|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 298: | Line 355: | ||
'''21-day cycles x 7 cycles''' | '''21-day cycles x 7 cycles''' | ||
− | ===Regimen #2, Randall et al. 2006=== | + | ===Regimen #2, Randall et al. 2006 {{#subobject:5baa3b|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 319: | Line 376: | ||
# Randall ME, Filiaci VL, Muss H, Spirtos NM, Mannel RS, Fowler J, Thigpen JT, Benda JA; Gynecologic Oncology Group Study. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2006 Jan 1;24(1):36-44. Epub 2005 Dec 5. [http://jco.ascopubs.org/content/24/1/36.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/16330675 PubMed] | # Randall ME, Filiaci VL, Muss H, Spirtos NM, Mannel RS, Fowler J, Thigpen JT, Benda JA; Gynecologic Oncology Group Study. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2006 Jan 1;24(1):36-44. Epub 2005 Dec 5. [http://jco.ascopubs.org/content/24/1/36.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/16330675 PubMed] | ||
− | ==Cisplatin, Doxorubicin, Paclitaxel== | + | ==Cisplatin, Doxorubicin, Paclitaxel {{#subobject:b61c1e|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:68777b|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 342: | Line 403: | ||
# Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, Kline R, Burger RA, Goodman A, Burks RT. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2004 Jun 1;22(11):2159-66. [http://jco.ascopubs.org/content/22/11/2159.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/15169803 PubMed] | # Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, Kline R, Burger RA, Goodman A, Burks RT. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2004 Jun 1;22(11):2159-66. [http://jco.ascopubs.org/content/22/11/2159.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/15169803 PubMed] | ||
− | ==Cisplatin, Ifosfamide, Mesna (CIM)== | + | ==Cisplatin, Ifosfamide, Mesna (CIM) {{#subobject:ac4dbb|Regimen=1}}== |
+ | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
CIM: '''<u>C</u>'''isplatin, '''<u>I</u>'''fosfamide, '''<u>M</u>'''esna | CIM: '''<u>C</u>'''isplatin, '''<u>I</u>'''fosfamide, '''<u>M</u>'''esna | ||
− | ===Regimen, Wolfson et al. 2007 (GOG 150)=== | + | ===Regimen, Wolfson et al. 2007 (GOG 150) {{#subobject:f97ea4|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 366: | Line 431: | ||
# Wolfson AH, Brady MF, Rocereto T, Mannel RS, Lee YC, Futoran RJ, Cohn DE, Ioffe OB. A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus. Gynecol Oncol. 2007 Nov;107(2):177-85. Epub 2007 Sep 5. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752331 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17822748 PubMed] | # Wolfson AH, Brady MF, Rocereto T, Mannel RS, Lee YC, Futoran RJ, Cohn DE, Ioffe OB. A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus. Gynecol Oncol. 2007 Nov;107(2):177-85. Epub 2007 Sep 5. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752331 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17822748 PubMed] | ||
− | ==Cisplatin & Paclitaxel== | + | ==Cisplatin & Paclitaxel {{#subobject:89fd88|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:b3c8fd|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 393: | Line 462: | ||
# Dimopoulos MA, Papadimitriou CA, Georgoulias V, Moulopoulos LA, Aravantinos G, Gika D, Karpathios S, Stamatelopoulos S. Paclitaxel and cisplatin in advanced or recurrent carcinoma of the endometrium: long-term results of a phase II multicenter study. Gynecol Oncol. 2000 Jul;78(1):52-7. [http://www.sciencedirect.com/science/article/pii/S009082580095827X link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10873410 PubMed] | # Dimopoulos MA, Papadimitriou CA, Georgoulias V, Moulopoulos LA, Aravantinos G, Gika D, Karpathios S, Stamatelopoulos S. Paclitaxel and cisplatin in advanced or recurrent carcinoma of the endometrium: long-term results of a phase II multicenter study. Gynecol Oncol. 2000 Jul;78(1):52-7. [http://www.sciencedirect.com/science/article/pii/S009082580095827X link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10873410 PubMed] | ||
− | ==Dactinomycin (Cosmegen)== | + | ==Dactinomycin (Cosmegen) {{#subobject:97a01a|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:2019ab|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 410: | Line 483: | ||
# Moore DH, Blessing JA, Dunton C, Buller RE, Reid GC. Dactinomycin in the treatment of recurrent or persistent endometrial carcinoma: A Phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 1999 Dec;75(3):473-5. [http://www.sciencedirect.com/science/article/pii/S0090825899956524 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10600310 PubMed] | # Moore DH, Blessing JA, Dunton C, Buller RE, Reid GC. Dactinomycin in the treatment of recurrent or persistent endometrial carcinoma: A Phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 1999 Dec;75(3):473-5. [http://www.sciencedirect.com/science/article/pii/S0090825899956524 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/10600310 PubMed] | ||
− | ==Ifosfamide== | + | ==Ifosfamide {{#subobject:b078a0|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:5e6305|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 434: | Line 511: | ||
# Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, Monk BJ, Ueland FR; Gynecologic Oncology Group. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007 Feb 10;25(5):526-31. [http://jco.ascopubs.org/content/25/5/526.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17290061 PubMed] | # Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, Monk BJ, Ueland FR; Gynecologic Oncology Group. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007 Feb 10;25(5):526-31. [http://jco.ascopubs.org/content/25/5/526.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17290061 PubMed] | ||
− | ==Ifosfamide & Paclitaxel== | + | ==Ifosfamide & Paclitaxel {{#subobject:824258|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:d519c4|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 462: | Line 543: | ||
# Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, Monk BJ, Ueland FR; Gynecologic Oncology Group. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007 Feb 10;25(5):526-31. [http://jco.ascopubs.org/content/25/5/526.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17290061 PubMed] | # Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, Monk BJ, Ueland FR; Gynecologic Oncology Group. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007 Feb 10;25(5):526-31. [http://jco.ascopubs.org/content/25/5/526.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/17290061 PubMed] | ||
− | ==Paclitaxel (Taxol)== | + | ==Paclitaxel (Taxol) {{#subobject:ceedf6|Regimen=1}}== |
− | ===Regimen #1, Lincoln et al. 2003=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen #1, Lincoln et al. 2003 {{#subobject:a2c4fa|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 483: | Line 568: | ||
*Cimetidine (Tagamet) 300 mg IV once 30 minutes prior to paclitaxel | *Cimetidine (Tagamet) 300 mg IV once 30 minutes prior to paclitaxel | ||
− | ===Regimen #2, Lissoni et al. 1996=== | + | ===Regimen #2, Lissoni et al. 1996 {{#subobject:f1656b|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 501: | Line 586: | ||
*Cimetidine (Tagamet) 300 mg IV once 1 hour prior to paclitaxel | *Cimetidine (Tagamet) 300 mg IV once 1 hour prior to paclitaxel | ||
− | ===Regimen #3, Ball et al. 1996=== | + | ===Regimen #3, Ball et al. 1996 {{#subobject:68d2e|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 527: | Line 612: | ||
# Lincoln S, Blessing JA, Lee RB, Rocereto TF. Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2003 Mar;88(3):277-81. [http://www.sciencedirect.com/science/article/pii/S0090825802000689 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/12648575 PubMed] | # Lincoln S, Blessing JA, Lee RB, Rocereto TF. Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2003 Mar;88(3):277-81. [http://www.sciencedirect.com/science/article/pii/S0090825802000689 link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/12648575 PubMed] | ||
− | ==Temsirolimus (Torisel)== | + | ==Temsirolimus (Torisel) {{#subobject:c19c6|Regimen=1}}== |
− | ===Regimen, Oza et al. 2011=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen, Oza et al. 2011 {{#subobject:53c722|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 544: | Line 633: | ||
# Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, Gotlieb WH, Hoskins PJ, Ghatage P, Tonkin KS, Mackay HJ, Mazurka J, Sederias J, Ivy P, Dancey JE, Eisenhauer EA. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol. 2011 Aug 20;29(24):3278-85. doi: 10.1200/JCO.2010.34.1578. Epub 2011 Jul 25. [http://jco.ascopubs.org/content/29/24/3278.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/21788564 PubMed] | # Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, Gotlieb WH, Hoskins PJ, Ghatage P, Tonkin KS, Mackay HJ, Mazurka J, Sederias J, Ivy P, Dancey JE, Eisenhauer EA. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol. 2011 Aug 20;29(24):3278-85. doi: 10.1200/JCO.2010.34.1578. Epub 2011 Jul 25. [http://jco.ascopubs.org/content/29/24/3278.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/21788564 PubMed] | ||
− | ==Topotecan (Hycamtin)== | + | ==Topotecan (Hycamtin) {{#subobject:9a02a0|Regimen=1}}== |
− | ===Regimen=== | + | {| class="wikitable" style="float:right; margin-left: 5px;" |
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
+ | ===Regimen {{#subobject:1c2f98|Variant=1}}=== | ||
Level of Evidence: | Level of Evidence: | ||
<span | <span | ||
Line 562: | Line 655: | ||
# Wadler S, Levy DE, Lincoln ST, Soori GS, Schink JC, Goldberg G. Topotecan is an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma: Eastern Cooperative Oncology Group Study E3E93. J Clin Oncol. 2003 Jun 1;21(11):2110-4. [http://jco.ascopubs.org/content/21/11/2110.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/12775736 PubMed] | # Wadler S, Levy DE, Lincoln ST, Soori GS, Schink JC, Goldberg G. Topotecan is an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma: Eastern Cooperative Oncology Group Study E3E93. J Clin Oncol. 2003 Jun 1;21(11):2110-4. [http://jco.ascopubs.org/content/21/11/2110.long link to original article] '''contains verified protocol''' [http://www.ncbi.nlm.nih.gov/pubmed/12775736 PubMed] | ||
− | ==Whole abdominal radiation (WAI)== | + | ==Whole abdominal radiation (WAI) {{#subobject:37c051|Regimen=1}}== |
+ | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
+ | |- | ||
+ | |[[#toc|back to top]] | ||
+ | |} | ||
− | ===Regimen=== | + | ===Regimen {{#subobject:1ab715|Variant=1}}=== |
Level of Evidence: | Level of Evidence: | ||
<span | <span |
Revision as of 06:58, 9 February 2015
Use of this site is subject to you reading and agreeing with the terms set forth in the disclaimer.
Is there a regimen missing from this list? Would you like to share a different dosage/schedule or an additional reference for a regimen? Have you noticed an error? Do you have an idea that will help the site grow to better meet your needs and the needs of many others? You are invited to contribute to the site.
35 regimens on this page
55 variants on this page
|
Hormone therapy for endometrioid histologies
Anastrozole (Arimidex)
back to top |
Level of Evidence: Phase II
- Anastrozole (Arimidex) 1 mg PO once per day
given until progression of disease or unacceptable toxicity
References
- Rose PG, Brunetto VL, VanLe L, Bell J, Walker JL, Lee RB. A phase II trial of anastrozole in advanced recurrent or persistent endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2000 Aug;78(2):212-6. link to original article contains verified protocol PubMed
Medroxyprogesterone acetate (MPA)
back to top |
Regimen
Level of Evidence: Phase III
- Medroxyprogesterone acetate (MPA) 200 mg PO once per day
given until progression of disease or unacceptable toxicity
References
- Thigpen JT, Brady MF, Alvarez RD, Adelson MD, Homesley HD, Manetta A, Soper JT, Given FT. Oral medroxyprogesterone acetate in the treatment of advanced or recurrent endometrial carcinoma: a dose-response study by the Gynecologic Oncology Group. J Clin Oncol. 1999 Jun;17(6):1736-44. link to original article contains verified protocol PubMed
Medroxyprogesterone acetate & Tamoxifen
back to top |
Regimen
Level of Evidence: Phase II
- Medroxyprogesterone acetate (MPA) 100 mg PO BID on even-numbered weeks (for example, week 2, 4, 6, etc.)
- Tamoxifen (Nolvadex) 20 mg PO BID
given until progression of disease or unacceptable toxicity
References
- Whitney CW, Brunetto VL, Zaino RJ, Lentz SS, Sorosky J, Armstrong DK, Lee RB; Gynecologic Oncology Group study. Phase II study of medroxyprogesterone acetate plus tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004 Jan;92(1):4-9. link to original article contains verified protocol PubMed
Megestrol acetate (Megace)
back to top |
Regimen
Level of Evidence: Randomized Phase II, >20 per arm
- Megestrol acetate (Megace) 80 mg PO BID
given until progression of disease or unacceptable toxicity
References
- Pandya KJ, Yeap BY, Weiner LM, Krook JE, Erban JK, Schinella RA, Davis TE. Megestrol and tamoxifen in patients with advanced endometrial cancer: an Eastern Cooperative Oncology Group Study (E4882). Am J Clin Oncol. 2001 Feb;24(1):43-6. link to original article contains verified protocol PubMed
Megestrol acetate & Tamoxifen
back to top |
Regimen
Level of Evidence: Randomized Phase II, >20 per arm
- Megestrol acetate (Megace) 80 mg PO BID x 3 weeks, alternating with tamoxifen
- Tamoxifen (Nolvadex) 20 mg PO BID x 3 weeks, alternating with megestrol
3-week courses of Megestrol acetate (Megace), alternating back and forth with 3-week courses of Tamoxifen (Nolvadex); given until progression of disease or unacceptable toxicity
References
- Pandya KJ, Yeap BY, Weiner LM, Krook JE, Erban JK, Schinella RA, Davis TE. Megestrol and tamoxifen in patients with advanced endometrial cancer: an Eastern Cooperative Oncology Group Study (E4882). Am J Clin Oncol. 2001 Feb;24(1):43-6. link to original article contains verified protocol PubMed
- Fiorica JV, Brunetto VL, Hanjani P, Lentz SS, Mannel R, Andersen W; Gynecologic Oncology Group study. Phase II trial of alternating courses of megestrol acetate and tamoxifen in advanced endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004 Jan;92(1):10-4. link to original article contains verified protocol PubMed
Tamoxifen (Nolvadex)
back to top |
Regimen
Level of Evidence: Phase II
- Tamoxifen (Nolvadex) 20 mg PO BID
given until progression of disease or unacceptable toxicity
References
- Quinn MA, Campbell JJ. Tamoxifen therapy in advanced/recurrent endometrial carcinoma. Gynecol Oncol. 1989 Jan;32(1):1-3. PubMed
- Thigpen T, Brady MF, Homesley HD, Soper JT, Bell J. Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group study. J Clin Oncol. 2001 Jan 15;19(2):364-7. link to original article contains verified protocol PubMed
Adjuvant radiation & chemotherapy
Cisplatin, Doxorubicin, RT
back to top |
Regimen
Level of Evidence: Phase III
Adjuvant radiation
- Radiation therapy to the pelvis, 1.8 Gy x 28 fractions (total dose: 50.4 Gy)
- Patients with positive para-aortic lymph nodes received 1.5 to 1.8 Gy x 24 to 29 fractions (total dose: 43.5 Gy)
6-week course, begins within 8 weeks after surgery
Chemotherapy
- Cisplatin (Platinol) 50 mg/m2 IV once on day 1, given second
- Doxorubicin (Adriamycin) 45 mg/m2 IV once on day 1, given first
- Body surface area capped at 2.0 m2
21-day cycles x 6 cycles, to start within 8 weeks after adjuvant radiation is complete
Supportive medications:
- Filgrastim (Neupogen) 5 mcg/kg SC once daily on days 2-11, or until ANC increases to 10,000; or Pegfilgrastim (Neulasta)
- Dexamethasone (Decadron) 10 mg IV once prior to chemotherapy
- 5-HT3 antagonist
References
- Homesley HD, Filiaci V, Gibbons SK, Long HJ, Cella D, Spirtos NM, Morris RT, DeGeest K, Lee R, Montag A. A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study. Gynecol Oncol. 2009 Mar;112(3):543-52. Epub 2008 Dec 23. link to original article contains verified protocol PubMed
Cisplatin, Doxorubicin, Paclitaxel, RT
back to top |
Regimen
Level of Evidence: Phase III
Adjuvant radiation
- Radiation therapy to the pelvis, 1.8 Gy x 28 fractions (total dose: 50.4 Gy)
- Patients with positive para-aortic lymph nodes received 1.5 to 1.8 Gy x 24 to 29 fractions (total dose: 43.5 Gy)
6-week course, begins within 8 weeks after surgery
Chemotherapy
- Cisplatin (Platinol) 50 mg/m2 IV once on day 1, given second
- Doxorubicin (Adriamycin) 45 mg/m2 IV once on day 1, given first
- Paclitaxel (Taxol) 160 mg/m2 IV over 3 hours once on day 2
- Body surface area capped at 2.0 m2
21-day cycles x 6 cycles, to start within 8 weeks after adjuvant radiation is complete
Supportive medications:
- Filgrastim (Neupogen) 5 mcg/kg SC once per day on days 3 to 12, or until ANC increases to 10,000
- Dexamethasone (Decadron) 10 mg IV once prior to day 1 chemotherapy; Dexamethasone (Decadron) 20 mg once 5 to 12 hours prior to paclitaxel on day 2
- 5-HT3 antagonist
References
- Homesley HD, Filiaci V, Gibbons SK, Long HJ, Cella D, Spirtos NM, Morris RT, DeGeest K, Lee R, Montag A. A randomized phase III trial in advanced endometrial carcinoma of surgery and volume directed radiation followed by cisplatin and doxorubicin with or without paclitaxel: A Gynecologic Oncology Group study. Gynecol Oncol. 2009 Mar;112(3):543-52. Epub 2008 Dec 23. link to original article contains verified protocol PubMed
Advanced, recurrent, or metastatic disease
Bevacizumab (Avastin)
back to top |
Regimen, Aghajanian et al. 2011
Level of Evidence: Phase II
- Bevacizumab (Avastin) 15 mg/kg IV once on day 1
21-day cycles, given until progression of disease or unacceptable toxicity
References
- Aghajanian C, Sill MW, Darcy KM, Greer B, McMeekin DS, Rose PG, Rotmensch J, Barnes MN, Hanjani P, Leslie KK. Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: a Gynecologic Oncology Group study. J Clin Oncol. 2011 Jun 1;29(16):2259-65. doi: 10.1200/JCO.2010.32.6397. Epub 2011 May 2. link to original article contains verified protocol PubMed
Carboplatin (Paraplatin)
back to top |
Regimen
Level of Evidence: Phase II
- Carboplatin (Paraplatin) 400 mg/m2 IV over 30 minutes once on day 1
- Dosage for patients with previously treated with chemotherapy is Carboplatin (Paraplatin) 300 mg/m2 IV over 30 minutes once on day 1
28-day cycles
References
- van Wijk FH, Lhommé C, Bolis G, Scotto di Palumbo V, Tumolo S, Nooij M, de Oliveira CF, Vermorken JB; European Organization for Research and Treatment of Cancer. Gynaecological Cancer Group. Phase II study of carboplatin in patients with advanced or recurrent endometrial carcinoma. A trial of the EORTC Gynaecological Cancer Group. Eur J Cancer. 2003 Jan;39(1):78-85. link to original article contains verified protocol PubMed
Carboplatin & Doxorubicin liposomal
back to top |
Regimen, Pignata et al. 2007 (END-1)
Level of Evidence: Phase II
- Carboplatin (Paraplatin) AUC 5 IV over 30 minutes once on day 1, given first
- Doxorubicin liposomal (Doxil) 40 mg/m2 IV over 60 minutes once on day 1, given second
28-day cycles x 3 to 6 cycles; all patients received 3 cycles of therapy. If there was no unacceptable toxicity, patients with stable or responsive disease received an additional 3 cycles.
Supportive medications:
- "No prophylactic use of G-CSF was recommended. In case of grade 4 neutropaenia, even without fever, therapeutic and prophylactic use of G-CSF was allowed."
References
- Pignata S, Scambia G, Pisano C, Breda E, Di Maio M, Greggi S, Ferrandina G, Lorusso D, Zagonel V, Febbraro A, Riva N, De Rosa V, Gallo C, Perrone F; Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies Group. A multicentre phase II study of carboplatin plus pegylated liposomal doxorubicin as first-line chemotherapy for patients with advanced or recurrent endometrial carcinoma: the END-1 study of the MITO (Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies) group. Br J Cancer. 2007 Jun 4;96(11):1639-43. Epub 2007 May 8. link to original article contains verified protocol PubMed
Carboplatin & Paclitaxel
back to top |
Regimen #1, Pectasides et al. 2008
Level of Evidence: Phase II
- Carboplatin (Paraplatin) AUC 5 IV over 1 hour once on day 1, given second
- Paclitaxel (Taxol) 175 mg/m2 IV over 3 hours once on day 1, given first
21-day cycles x 6 to 9 cycles
Regimen #2, Hoskins et al. 2001 & Shechter-Maor et al. 2008
Level of Evidence: Phase II
- Carboplatin (Paraplatin) AUC 5 to 7 IV once on day 1, given second
- Paclitaxel (Taxol) 175 mg/m2 IV over 3 hours once on day 1, given first
21-day cycles
Regimen #3, Sorbe et al. 2008
Level of Evidence: Phase II
- Carboplatin (Paraplatin) AUC 5 IV once on day 1
- Paclitaxel (Taxol) 175 mg/m2 IV once on day 1
21-day cycles
References
- Hoskins PJ, Swenerton KD, Pike JA, Wong F, Lim P, Acquino-Parsons C, Lee N. Paclitaxel and carboplatin, alone or with irradiation, in advanced or recurrent endometrial cancer: a phase II study. J Clin Oncol. 2001 Oct 15;19(20):4048-53. link to original article contains verified protocol PubMed
- Pectasides D, Xiros N, Papaxoinis G, Pectasides E, Sykiotis C, Koumarianou A, Psyrri A, Gaglia A, Kassanos D, Gouveris P, Panayiotidis J, Fountzilas G, Economopoulos T. Carboplatin and paclitaxel in advanced or metastatic endometrial cancer. Gynecol Oncol. 2008 May;109(2):250-4. Epub 2008 Mar 4. link to original article contains verified protocol PubMed content property of HemOnc.org
- Sorbe B, Andersson H, Boman K, Rosenberg P, Kalling M. Treatment of primary advanced and recurrent endometrial carcinoma with a combination of carboplatin and paclitaxel-long-term follow-up. Int J Gynecol Cancer. 2008 Jul-Aug;18(4):803-8. Epub 2007 Oct 18. PubMed
- Retrospective: Shechter-Maor G, Bruchim I, Ben-Harim Z, Altaras M, Fishman A. Combined chemotherapy regimen of carboplatin and paclitaxel as adjuvant treatment for papillary serous and clear cell endometrial cancer. Int J Gynecol Cancer. 2009 May;19(4):662-4. link to original article PubMed
Cisplatin & Doxorubicin
back to top |
Regimen #1, Fleming et al. 2004
Level of Evidence: Phase III
- Cisplatin (Platinol) 50 mg/m2 IV over 1 hour once on day 1, given second
- Doxorubicin (Adriamycin) 60 mg/m2 IV once on day 1, given first
- Dosage for patients with previous pelvic radiation or who were >65 years old is Doxorubicin (Adriamycin) 45 mg/m2 IV once on day 1
- Body surface area capped at 2.0 m2
21-day cycles x 7 cycles
Regimen #2, Randall et al. 2006
Level of Evidence: Phase III
- Cisplatin (Platinol) 50 mg/m2 IV once on day 1 of cycles 1 to 8
- Doxorubicin (Adriamycin) 60 mg/m2 IV once on day 1 of cycles 1 to 7
21-day cycles x 8 cycles
Supportive hydration:
- Normal saline at 500 mL/H for 2 hours prior to and after cisplatin
References
- Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, Kline R, Burger RA, Goodman A, Burks RT. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2004 Jun 1;22(11):2159-66. link to original article contains verified protocol PubMed
- Randall ME, Filiaci VL, Muss H, Spirtos NM, Mannel RS, Fowler J, Thigpen JT, Benda JA; Gynecologic Oncology Group Study. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2006 Jan 1;24(1):36-44. Epub 2005 Dec 5. link to original article contains verified protocol PubMed
Cisplatin, Doxorubicin, Paclitaxel
back to top |
Regimen
Level of Evidence: Phase III
- Cisplatin (Platinol) 50 mg/m2 IV over 1 hour once on day 1, given second
- Doxorubicin (Adriamycin) 45 mg/m2 IV once on day 1, given first
- Paclitaxel (Taxol) 160 mg/m2 IV over 3 hours once on day 2
- Body surface area capped at 2.0 m2
21-day cycles x 7 cycles
Supportive medications:
- Filgrastim (Neupogen) 5 mcg/kg SC once per day on days 3 to 12
References
- Fleming GF, Brunetto VL, Cella D, Look KY, Reid GC, Munkarah AR, Kline R, Burger RA, Goodman A, Burks RT. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2004 Jun 1;22(11):2159-66. link to original article contains verified protocol PubMed
Cisplatin, Ifosfamide, Mesna (CIM)
back to top |
CIM: Cisplatin, Ifosfamide, Mesna
Regimen, Wolfson et al. 2007 (GOG 150)
Level of Evidence: Phase III
- Cisplatin (Platinol) 20 mg/m2 IV at an infusion rate of approximately 1 mg/min once per day on days 1 to 4, given first
- Ifosfamide (Ifex) 1500 mg/m2 IV over 1 hour once per day on days 1 to 4, given second together with mesna
- Mesna (Mesnex) 120 mg/m2 IV bolus over 15 minutes once on day 1;, then Mesna (Mesnex) 1500 mg/m2/day IV continuous infusion over 96 hours on days 1 to 4, given second together with ifosfamide
21-day cycles x 3 cycles
Supportive medications:
- Suggested hydration: 1 liter of NS or 1/2 NS given over several hours prior to chemotherapy
References
- Wolfson AH, Brady MF, Rocereto T, Mannel RS, Lee YC, Futoran RJ, Cohn DE, Ioffe OB. A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus. Gynecol Oncol. 2007 Nov;107(2):177-85. Epub 2007 Sep 5. link to original article contains verified protocol PubMed
Cisplatin & Paclitaxel
back to top |
Regimen
Level of Evidence: Phase II
- Cisplatin (Platinol) 75 mg/m2 IV over 2 hours once on day 1, given second
- Paclitaxel (Taxol) 175 mg/m2 IV over 3 hours once on day 1, given first
21-day cycles x up to 6 cycles
Supportive medications:
- Dexamethasone (Decadron) 20 mg PO/IV given twice, 12 and 6 hours prior to paclitaxel
- Diphenhydramine (Benadryl) 25 mg IV once 30 minutes prior to paclitaxel
- Ranitidine (Zantac) 50 mg IV once 30 minutes prior to paclitaxel
- 900 mL normal saline mixed with 100 mL mannitol given over 1 hour prior to cisplatin
- 2 liters NS with potassium & magnesium after cisplatin
- "Appropriate antiemetics"
- Filgrastim (Neupogen) 5 mcg/kg SC once per day, starting on day 5 and continuing until WBC >10,000
References
- Dimopoulos MA, Papadimitriou CA, Georgoulias V, Moulopoulos LA, Aravantinos G, Gika D, Karpathios S, Stamatelopoulos S. Paclitaxel and cisplatin in advanced or recurrent carcinoma of the endometrium: long-term results of a phase II multicenter study. Gynecol Oncol. 2000 Jul;78(1):52-7. link to original article contains verified protocol PubMed
Dactinomycin (Cosmegen)
back to top |
Regimen
Level of Evidence: Phase II
- Dactinomycin (Cosmegen) 2 mg/m2 IV over 15 minutes once on day 1
28-day cycles
References
- Moore DH, Blessing JA, Dunton C, Buller RE, Reid GC. Dactinomycin in the treatment of recurrent or persistent endometrial carcinoma: A Phase II study of the Gynecologic Oncology Group. Gynecol Oncol. 1999 Dec;75(3):473-5. link to original article contains verified protocol PubMed
Ifosfamide
back to top |
Regimen
Level of Evidence: Phase III
Note: Homesley et al. 2007 specifies that PO Mesna (Mesnex) is to be taken in 3 divided doses, but only lists 2 time points for its use. The timing of the middle dose is estimated based on other references.
- Ifosfamide (Ifex) 1600 mg/m2 IV once per day on days 1 to 3
- Dosage for patients with previous radiation is Ifosfamide (Ifex) 1200 mg/m2 IV once per day on days 1 to 3
- Mesna (Mesnex) 2000 mg IV over 12 hours once per day on days 1 to 3, starting 15 minutes before ifosfamide
- Alternate PO dosing: Mesna (Mesnex) 1330 mg PO taken three times per day, 1 hour before, 4 hours after, and 8 hours after ifosfamide (4000 mg total dose per day), on days 1 to 3
21-day cycles x 8 cycles
Supportive medications:
- Filgrastim (Neupogen) 5 mcg/kg SC once per day starting on day 4, to continue until ANC is greater than or equal to 2000
References
- Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, Monk BJ, Ueland FR; Gynecologic Oncology Group. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007 Feb 10;25(5):526-31. link to original article contains verified protocol PubMed
Ifosfamide & Paclitaxel
back to top |
Regimen
Level of Evidence: Phase III
Note: Homesley et al. 2007 specifies that PO Mesna (Mesnex) is to be taken in 3 divided doses, but only lists 2 time points for its use. The timing of the middle dose is estimated based on other references.
- Ifosfamide (Ifex) 1600 mg/m2 IV once per day on days 1 to 3
- Dosage for patients with previous radiation is Ifosfamide (Ifex) 1200 mg/m2 IV once per day on days 1 to 3
- Mesna (Mesnex) 2000 mg IV over 12 hours once per day on days 1 to 3, starting 15 minutes before ifosfamide
- Alternate PO dosing: Mesna (Mesnex) 1330 mg PO taken three times per day, 1 hour before, 4 hours after, and 8 hours after ifosfamide (4000 mg total dose per day), on days 1 to 3
- Paclitaxel (Taxol) 135 mg/m2 IV over 3 hours once on day 1
21-day cycles x 8 cycles
Supportive medications:
- Filgrastim (Neupogen) 5 mcg/kg SC once per day starting on day 4, to continue until ANC is greater than or equal to 2000
- Dexamethasone (Decadron) 20 mg PO/IV given twice, 12 and 6 hours prior to paclitaxel
- Diphenhydramine (Benadryl) 50 mg IV once 30 minutes prior to paclitaxel
- Cimetidine (Tagamet) 300 mg IV or Ranitidine (Zantac) 50 mg IV once 30 minutes prior to paclitaxel
References
- Homesley HD, Filiaci V, Markman M, Bitterman P, Eaton L, Kilgore LC, Monk BJ, Ueland FR; Gynecologic Oncology Group. Phase III trial of ifosfamide with or without paclitaxel in advanced uterine carcinosarcoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2007 Feb 10;25(5):526-31. link to original article contains verified protocol PubMed
Paclitaxel (Taxol)
back to top |
Regimen #1, Lincoln et al. 2003
Level of Evidence: Phase II
- Paclitaxel (Taxol) 200 mg/m2 IV over 3 hours once on day 1
- Dosage for patients with previous pelvic radiation is Paclitaxel (Taxol) 175 mg/m2 IV over 3 hours once on day 1
- Dose of Paclitaxel (Taxol) can be changed to 135 or 110 mg/m2 depending on toxicity
21-day cycles
Supportive medications:
- Dexamethasone (Decadron) 20 mg PO/IV given twice, 12 and 6 hours prior to paclitaxel
- Diphenhydramine (Benadryl) 50 mg PO/IV once 30 minutes prior to paclitaxel
- Cimetidine (Tagamet) 300 mg IV once 30 minutes prior to paclitaxel
Regimen #2, Lissoni et al. 1996
Level of Evidence: Phase II
- Paclitaxel (Taxol) 175 mg/m2 IV over 3 hours once on day 1
21-day cycles
Supportive medications:
- Hydrocortisone (Cortef) 250 mg IV once 1 hour prior to paclitaxel
- Chlorphenamine/chlorpheniramine (H1 blocker) 10 mg IM once 1 hour prior to paclitaxel
- Cimetidine (Tagamet) 300 mg IV once 1 hour prior to paclitaxel
Regimen #3, Ball et al. 1996
Level of Evidence: Phase II
- Paclitaxel (Taxol) 250 mg/m2 IV continuous infusion over 24 hours once on day 1
- Dosage for patients with previous pelvic radiation is Paclitaxel (Taxol) 200 mg/m2 IV continuous infusion over 24 hours once on day 1
- Dose of Paclitaxel (Taxol) can be changed to 200, 170, 135, 110 mg/m2 depending on toxicity
21-day cycles
Supportive medications:
- Dexamethasone (Decadron) 20 mg PO/IV given twice, 12 and 6 hours prior to paclitaxel
- Diphenhydramine (Benadryl) 50 mg PO/IV once 30 minutes prior to paclitaxel
- Cimetidine (Tagamet) 300 mg IV once 30 minutes prior to paclitaxel
- Filgrastim (Neupogen) 5 mcg/kg SC once per day starting on day 3, 24 hours after chemotherapy, continued for at least 12 days or until two successive total leukocyte counts are 10,000 or greater, whichever comes last
References
- Ball HG, Blessing JA, Lentz SS, Mutch DG. A phase II trial of paclitaxel in patients with advanced or recurrent adenocarcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol. 1996 Aug;62(2):278-81. link to original article contains verified protocol PubMed
- Lissoni A, Zanetta G, Losa G, Gabriele A, Parma G, Mangioni C. Phase II study of paclitaxel as salvage treatment in advanced endometrial cancer. Ann Oncol. 1996 Oct;7(8):861-3. link to original article contains verified protocol PubMed
- Lincoln S, Blessing JA, Lee RB, Rocereto TF. Activity of paclitaxel as second-line chemotherapy in endometrial carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2003 Mar;88(3):277-81. link to original article contains verified protocol PubMed
Temsirolimus (Torisel)
back to top |
Regimen, Oza et al. 2011
Level of Evidence: Phase II
- Temsirolimus (Torisel) 25 mg IV over 30 minutes once per day on days 1, 8, 15, 22
28-day cycles, given until progression of disease, unacceptable toxicity, or patient decision
References
- Oza AM, Elit L, Tsao MS, Kamel-Reid S, Biagi J, Provencher DM, Gotlieb WH, Hoskins PJ, Ghatage P, Tonkin KS, Mackay HJ, Mazurka J, Sederias J, Ivy P, Dancey JE, Eisenhauer EA. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: a trial of the NCIC Clinical Trials Group. J Clin Oncol. 2011 Aug 20;29(24):3278-85. doi: 10.1200/JCO.2010.34.1578. Epub 2011 Jul 25. link to original article contains verified protocol PubMed
Topotecan (Hycamtin)
back to top |
Regimen
Level of Evidence: Phase II
- Topotecan (Hycamtin) 1.5 mg/m2 IV once per day on days 1 to 5
- Dosage for patients with previous pelvic radiation is Topotecan (Hycamtin) 1.2 mg/m2, which can be increase to the 1.5 mg/m2 dose in later cycles if there are no toxicities higher than grade 1
21-day cycles
References
- Wadler S, Levy DE, Lincoln ST, Soori GS, Schink JC, Goldberg G. Topotecan is an active agent in the first-line treatment of metastatic or recurrent endometrial carcinoma: Eastern Cooperative Oncology Group Study E3E93. J Clin Oncol. 2003 Jun 1;21(11):2110-4. link to original article contains verified protocol PubMed
Whole abdominal radiation (WAI)
back to top |
Regimen
Level of Evidence: Phase III
Not commonly used but was a comparator arm; here for reference purposes only.
References
- Randall ME, Filiaci VL, Muss H, Spirtos NM, Mannel RS, Fowler J, Thigpen JT, Benda JA; Gynecologic Oncology Group Study. Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2006 Jan 1;24(1):36-44. Epub 2005 Dec 5. link to original article contains verified protocol PubMed
- Wolfson AH, Brady MF, Rocereto T, Mannel RS, Lee YC, Futoran RJ, Cohn DE, Ioffe OB. A gynecologic oncology group randomized phase III trial of whole abdominal irradiation (WAI) vs. cisplatin-ifosfamide and mesna (CIM) as post-surgical therapy in stage I-IV carcinosarcoma (CS) of the uterus. Gynecol Oncol. 2007 Nov;107(2):177-85. Epub 2007 Sep 5. link to original article contains verified protocol PubMed