Filgrastim (Neupogen)

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General information

Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation.[1][2][3]
Route: SC, IV
Extravasation: no known issues

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Note that colony stimulating factors are used for their adjuvant effect e.g. removing leukemia stem cells from their protective niches; they are not thought to have inherent anti-cancer activity.

Patient drug information

History of changes in FDA indication

  • 2/20/1991: Initial FDA approval.
  • Currently approved to:
    • "Decrease the incidence of infection‚ as manifested by febrile neutropenia‚ in patients with nonmyeloid malignancies receiving myelosuppressive anticancer drugs associated with a significant incidence of severe neutropenia with fever"
    • "Reduce the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia (AML)"
    • "Reduce the duration of neutropenia and neutropenia-related clinical sequelae‚ e.g.‚ febrile neutropenia, in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation (BMT)"
    • "Mobilize autologous hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis"
    • "Reduce the incidence and duration of sequelae of severe neutropenia (e.g.‚fever‚ infections‚ oropharyngeal ulcers) in symptomatic patients with congenital neutropenia‚ cyclic neutropenia‚ or idiopathic neutropenia"

Also known as

Synonyms
BAO LI JIN Biocilin Biofigran Biofilgran Euprotin Filatil Filgen Filgrastim
Filgrastima GCSF G-CSF Gran Gran Kirin Gran Sankyo Granulocyte Colony Stimulating Factor Granulokine
Grasalva Grasin Grastim Leicita Leubene Leucin Leucocim Leucokain
Leucostim Leukokine Leumostin Lioplim LI Sheng SU Mielastra Myelostim Neipogen
Neitrostim Neukine Neupogen Neupogen Amgen 48 Neupogen Novum Neupogen Singleject Nevkine Nivestim
RUI BAI TE ER JIN Topneuter XIN LI Sheng

References

  1. 1.0 1.1 1.2 Filgrastim (Neupogen) package insert
  2. Filgrastim (Neupogen) package insert (locally hosted backup)
  3. Neupogen manufacturer's website
  4. Filgrastim (Neupogen) patient drug information (Chemocare)
  5. Filgrastim (Neupogen) patient drug information (UpToDate)