Pegfilgrastim (Neulasta)

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General information

Class/mechanism: Recombinant human granulocyte colony-stimulating factor (G-CSF). Binds to cell surface receptors on hematopoietic cells and stimulates proliferation‚ differentiation, and some end-cell functional activation. The Neulasta formulation involves Filgrastim (Neupogen) being covalently conjugated to monomethoxypolyethylene glycol (mPEG), increasing its half-life.[1][2][3]
Route: SC
Extravasation: n/a

  • "Do not administer Neulasta between 14 days before and 24 hours after administration of cytotoxic chemotherapy."[1]

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

  • Generic names: pegylated GCSF, pegylated G-CSF, pegylated granulocyte colony stimulating factor
  • Brand names: Neulasta, Onpro


  1. 1.0 1.1 1.2 1.3 Pegfilgrastim (Neulasta) package insert
  2. Pegfilgrastim (Neulasta) package insert (locally hosted backup)
  3. Neulasta manufacturer's website
  4. Pegfilgrastim (Neulasta) patient drug information (Chemocare)
  5. Pegfilgrastim (Neulasta) patient drug information (UpToDate)