Amifostine (Ethyol)

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General information

Class/mechanism: Prodrug of a free thiol metabolite, converted to the active form by alkaline phosphatase, that reduces the cumulative renal toxicity of cisplatin and oral toxicity of radiation by scavaging reactive metabolites and reactive oxygen species. Amifostine is thought to preferentially protect normal tissues because they have higher alkaline phosphatase activity, higher pH, and better vascularity.[1][2]
Route: IV
Extravasation: no information

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

  • Brand names: Cytofos, Ethyol


  1. 1.0 1.1 Amifostine (Ethyol) package insert
  2. Amifostine (Ethyol) package insert (locally hosted backup)
  3. Amifostine (Ethyol) patient drug information (Chemocare)
  4. Amifostine (Ethyol) patient drug information (UpToDate)