Soft tissue sarcoma

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Single-agent regimens

Dacarbazine (DTIC)

Regimen, Buesa, et al. 1991

• Dacarbazine (DTIC) 1200 mg/m2 in 200 mL normal saline IV over 20 minutes once on day 1

21-day cycles, given until progression of disease

Supportive medications:

• Calcium gluconate (10% solution) 5 mL IV every 10 minutes x 3 doses (total of 15 mL) after the start of dacarbazine; 2 additional doses of calcium gluconate (10% solution) 5 mL IV every 10 minutes were given to patients whose systolic blood pressure decreased below 80 mmHg or heart rate ≥160 beat/minute.

References

1. Buesa JM, Mouridsen HT, van Oosterom AT, Verweij J, Wagener T, Steward W, Poveda A, Vestlev PM, Thomas D, Sylvester R. High-dose DTIC in advanced soft-tissue sarcomas in the adult. A phase II study of the E.O.R.T.C. Soft Tissue and Bone Sarcoma Group. Ann Oncol. 1991 Apr;2(4):307-9. link to original article contains verified protocol PubMed

Doxorubicin (Adriamycin)

Regimen

• Doxorubicin (Adriamycin) 75 mg/m2 IV bolus once on day 1

21-day cycles x up to 6 cycles, until progression of disease, unacceptable toxicity, or patient refusal. In Mouridsen, et al. 1987, treatment was given until progression of disease, unacceptable toxicity, or cumulative doxorubicin dosage of 550 mg/m2, though the ultimate decision to stop treatment based on cumulative doxorubicin dosage was at the discretion of the treating physician.

References

1. Mouridsen HT, Bastholt L, Somers R, Santoro A, Bramwell V, Mulder JH, van Oosterom AT, Buesa J, Pinedo HM, Thomas D, et al. Adriamycin versus epirubicin in advanced soft tissue sarcomas. A randomized phase II/phase III study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer Clin Oncol. 1987 Oct;23(10):1477-83. contains verified protocol PubMed
2. Bramwell VH, Anderson D, Charette ML. Doxorubicin-based chemotherapy for the palliative treatment of adult patients with locally advanced or metastatic soft-tissue sarcoma: a meta-analysis and clinical practice guideline. Sarcoma. 2000;4(3):103-12. doi: 10.1080/13577140020008066. link to original article PubMed
3. Lorigan P, Verweij J, Papai Z, Rodenhuis S, Le Cesne A, Leahy MG, Radford JA, Van Glabbeke MM, Kirkpatrick A, Hogendoorn PC, Blay JY; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 2007 Jul 20;25(21):3144-50. link to original article contains verified protocol PubMed

Epirubicin (Ellence)

Regimen

• Epirubicin (Ellence) 75 mg/m2 IV bolus once on day 1

21-day cycles, given until progression of disease, unacceptable toxicity, or cumulative epirubicin dosage of 550 mg/m2 (though the ultimate decision to stop treatment based on cumulative epirubicin dosage was at the discretion of the treating physician)

References

1. Mouridsen HT, Bastholt L, Somers R, Santoro A, Bramwell V, Mulder JH, van Oosterom AT, Buesa J, Pinedo HM, Thomas D, et al. Adriamycin versus epirubicin in advanced soft tissue sarcomas. A randomized phase II/phase III study of the EORTC Soft Tissue and Bone Sarcoma Group. Eur J Cancer Clin Oncol. 1987 Oct;23(10):1477-83. contains verified protocol PubMed

Ifosfamide (Ifex)

Regimen #1, van Oosterom, et al. 2002

• Ifosfamide (Ifex) 3000 mg/m2 IV over 4 hours once daily on days 1-3
  • Each day's dose of ifosfamide is dissolved in 125 mL sterile water per 1000 mg of ifosfamide, mixed together with mesna in an additional 1 liter of dextrose/saline
• Mesna (Mesnex) 600 mg/m2 IV bolus once on day 1, immediately prior to mesna/ifosfamide infusion
• Mesna (Mesnex) 1500 mg/m2 IV over 4 hours on days 1-3, given together with ifosfamide
• Mesna (Mesnex) 500 mg/m2 IV two times per day on days 1-3, given at 4 and 8 hours after completion of ifosfamide and mesna

21-day cycles x at least 2 cycles, except in cases of rapid disease progression; continued until disease progression or unacceptable toxicity or patient refusal

Supportive medications:

• "Antiemetics were prescribed according to local conventions"
• 1 liter of fluid PO two times per day on days 1-3, taken 4 and 8 hours after completion of ifosfamide and mesna

Regimen #2, Lorigan, et al. 2007 - short infusion, Ifos 3

• Ifosfamide (Ifex) 3000 mg/m2 IV over 4 hours on days 1-3, given together with mesna
  • Each day's dose of ifosfamide is mixed together with mesna in 1 liter of normal saline
• Mesna (Mesnex) 600 mg/m2 IV bolus once on day 1, immediately prior to mesna/ifosfamide infusion
• Mesna (Mesnex) 1500 mg/m2 IV over 4 hours on days 1-3, given together with ifosfamide
• Mesna (Mesnex) 1200 mg/m2 IV two times per day on days 1-3, given at 4 and 8 hours after completion of ifosfamide and mesna
  • An alternative is to use oral mesna instead of intravenous: Mesna (Mesnex) 1200 mg/m2 PO two times per day on days 1-3, given at 2 and 6 hours after completion of ifosfamide and mesna

21-day cycles x up to 6 cycles, until progression of disease, unacceptable toxicity, or patient refusal

Supportive medications:

• Sodium bicarbonate 150 mmol IV once daily on days 1-3
• Patient with somnolesence or other signs of encephalopathy with ifosfamide received methylene blue 50 mg IV every 4 hours until resolution of symptoms. During cycles thereafter, patients would receive methylene blue 50 mg IV every 4 hours, starting 4 hours prior to ifosfamide on day 1, continuing until 72 hours after completion

Regimen #3, Lorigan, et al. 2007 - continuous infusion, Ifos 9

• Ifosfamide (Ifex) 3000 mg/m2/day IV continuous infusion over 72 hours (total dose per cycle: 9000 mg/m2) on days 1-3, given together with mesna
  • Each day's dose of ifosfamide is mixed together with mesna in 3 liters of normal saline
• Mesna (Mesnex) 600 mg/m2 IV bolus once on day 1, immediately prior to mesna/ifosfamide infusion
• Mesna (Mesnex) 3000 mg/m2/day IV continuous infusion over 72 hours (total dose per cycle: 9000 mg/m2) on days 1-3, given together with ifosfamide
• Mesna (Mesnex) 1800 mg/m2 IV over 12 hours once on day 4, starting after completion of ifosfamide and mesna
  • An alternative is to use oral mesna instead of intravenous: Mesna (Mesnex) 1200 mg/m2 PO three times on day 4, given 0, 2, and 6 hours after completion of ifosfamide and mesna

21-day cycles x up to 6 cycles, until progression of disease, unacceptable toxicity, or patient refusal

Supportive medications:

• Sodium bicarbonate 150 mmol IV once daily on days 1-3
• Patient with somnolesence or other signs of encephalopathy with ifosfamide received methylene blue 50 mg IV every 4 hours until resolution of symptoms. During cycles thereafter, patients would receive methylene blue 50 mg IV every 4 hours, starting 4 hours prior to ifosfamide on day 1, continuing until 72 hours after completion

References

1. van Oosterom AT, Mouridsen HT, Nielsen OS, Dombernowsky P, Krzemieniecki K, Judson I, Svancarova L, Spooner D, Hermans C, Van Glabbeke M, Verweij J; EORTC Soft Tissue and Bone Sarcoma Group. Results of randomised studies of the EORTC Soft Tissue and Bone Sarcoma Group (STBSG) with two different ifosfamide regimens in first- and second-line chemotherapy in advanced soft tissue sarcoma patients. Eur J Cancer. 2002 Dec;38(18):2397-406 link to original article contains verified protocol PubMed content property of HemOnc.org
2. Lorigan P, Verweij J, Papai Z, Rodenhuis S, Le Cesne A, Leahy MG, Radford JA, Van Glabbeke MM, Kirkpatrick A, Hogendoorn PC, Blay JY; European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. Phase III trial of two investigational schedules of ifosfamide compared with standard-dose doxorubicin in advanced or metastatic soft tissue sarcoma: a European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Study. J Clin Oncol. 2007 Jul 20;25(21):3144-50. link to original article contains verified protocol PubMed

Pazopanib (Votrient)

Regimen, van der Graaf, et al. 2012 - PALETTE

• Pazopanib (Votrient) 800 mg PO once daily

given until progression of disease, unacceptable toxicity, withdrawal of consent, or death

References

1. van der Graaf WT, Blay JY, Chawla SP, Kim DW, Bui-Nguyen B, Casali PG, Sch�ffski P, Aglietta M, Staddon AP, Beppu Y, Le Cesne A, Gelderblom H, Judson IR, Araki N, Ouali M, Marreaud S, Hodge R, Dewji MR, Coens C, Demetri GD, Fletcher CD, Dei Tos AP, Hohenberger P; EORTC Soft Tissue and Bone Sarcoma Group; PALETTE study group. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet. 2012 May 19;379(9829):1879-86. doi: 10.1016/S0140-6736(12)60651-5. Epub 2012 May 16. link to original article contains verified protocol PubMed

Temozolomide (Temodar)

Regimen #1, Talbot, et al. 2003

• Temozolomide (Temodar) 200 mg/m2 (doses rounded up if needed to next available dosage based on capsule doses) PO once on day 1, on an empty stomach; then 12 hours later, Temozolomide (Temodar) 90 mg/m2 PO once every 12 hours x 9 doses (total of 10 doses per cycle) on days 1-5, on an empty stomach

28-day cycles, given until progression of disease x 1 year; patients on study could be reconsented to receive therapy beyond 1 year

Supportive medications:

• Antiemetics "prescribed as clinically indicated by the treating physician"

Regimen #2, Garcia del Muro, et al. 2005

• Temozolomide (Temodar) 100 mg/m2 PO once daily on days 1-42 (6 weeks), with no food 1 hour before and after temozolomide doses
  • Initial dose used in the study was 75 mg/m2, but due to lack of toxicity, protocol was amended to use 100 mg/m2 doses

9-week cycles x up to 3 cycles, progression of disease, or unacceptable toxicity

Supportive medications:

• "Antiemetics, mainly oral metoclopramide and ondansetron, were prescribed as clinically indicated by the treating physician"

References

1. Talbot SM, Keohan ML, Hesdorffer M, Orrico R, Bagiella E, Troxel AB, Taub RN. A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. Cancer. 2003 Nov 1;98(9):1942-6. link to original article contains verified protocol PubMed
2. Garcia del Muro X, Lopez-Pousa A, Martin J, Buesa JM, Martinez-Trufero J, Casado A, Poveda A, Cruz J, Bover I, Maurel J; Spanish Group for Research on Sarcomas. A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas. Cancer. 2005 Oct 15;104(8):1706-12. link to original article contains verified protocol PubMed

Combination regimens

AIM

AIM: Adriamycin, Ifosfamide, Mesna

Regimen #1, Patel, et al. 1998 - 5-day course, lower dose doxorubicin - AI 75/10

• Doxorubicin (Adriamycin) 25 mg/m2/day IV continuous infusion over 72 hours (total dose per cycle: 75 mg/m2) on days 1-3
• Ifosfamide (Ifex) 2000 mg/m2 IV over 2 hours once daily on days 1-5 (total dose per cycle: 10,000 mg/m2)
• Mesna (Mesnex) 400 mg/m2 IV once on day 1, given simultaneously with the first dose of ifosfamide
• Mesna (Mesnex) 1200 mg/m2/day IV continuous infusion over 5 days (total dose per cycle: 6000 mg/m2) on days 1-5
  • Each day's dose of mesna is given in 2 liters of D5W with 100 mEq/L sodium acetate, 20 mEq/L potassium acetate, and 4 mEq/L magnesium sulfate

21-day cycles, given until maximum response, 6 cycles of therapy, progression of disease, or unacceptable toxicity

Supportive medications:

• If febrile neutropenia occurs, G-CSF is used in subsequent cycles

Regimen #2, Patel, et al. 1998 - 4-day course, higher dose doxorubicin - AI 90/10

• Doxorubicin (Adriamycin) 30 mg/m2/day IV continuous infusion over 72 hours (total dose per cycle: 90 mg/m2) on days 1-3
• Ifosfamide (Ifex) 2500 mg/m2 IV over 3 hours once daily on days 1-4 (total dose per cycle: 10,000 mg/m2)
• Mesna (Mesnex) 500 mg/m2 IV once on day 1, given simultaneously with the first dose of ifosfamide
• Mesna (Mesnex) 1500 mg/m2/day IV continuous infusion over 4 days (total dose per cycle: 6000 mg/m2) on days 1-4
  • Each day's dose of mesna is given in 2 liters of D5W with 100 mEq/L sodium acetate, 20 mEq/L potassium acetate, and 4 mEq/L magnesium sulfate

21-day cycles, given until maximum response, 6 cycles of therapy, progression of disease, or unacceptable toxicity

Supportive medications:

• G-CSF 5 mcg/kg (dose rounded to 300 or 480 mcg) SC once daily, starting on day 5, given until ANC is at least 10,000

References

1. Patel SR, Vadhan-Raj S, Burgess MA, Plager C, Papadopolous N, Jenkins J, Benjamin RS. Results of two consecutive trials of dose-intensive chemotherapy with doxorubicin and ifosfamide in patients with sarcomas. Am J Clin Oncol. 1998 Jun;21(3):317-21. link to original article contains verified protocol PubMed

Epirubicin (Ellence) & Ifosfamide (Ifex)

Regimen

• Epirubicin (Ellence) 45 mg/m2/day IV continuous infusion over 2 days (total dose per cycle: 90 mg/m2) on days 2-3
• Ifosfamide (Ifex) 2500 mg/m2/day IV continuous infusion over 5 days (total dose per cycle: 12,500 mg/m2) on days 1-5, given together with mesna
  • Each day's dose of ifosfamide is mixed together with mesna in 3 liters of "fluids with electrolytes"
• Mesna (Mesnex) 1500 mg/m2 IV continuous infusion over 5 days (total dose per cycle: 7500 mg/m2) on days 1-5, given together with ifosfamide

21-day cycles

Supportive medications:

• G-CSF 5 mcg/kg SC once daily on days 6-15 or "until recovery of leukocytes"
• Ondansetron (Zofran) 8-24 mg per day prn nausea
• Dexamethasone (Decadron) (dose/schedule not specified) for antiemesis if necessary

References

1. Reichardt P, Tilgner J, Hohenberger P, D�rken B. Dose-intensive chemotherapy with ifosfamide, epirubicin, and filgrastim for adult patients with metastatic or locally advanced soft tissue sarcoma: a phase II study. J Clin Oncol. 1998 Apr;16(4):1438-43. link to original article contains verified protocol PubMed

Gemcitabine (Gemzar) & Docetaxel (Taxotere)

Regimen #1, Hensley, et al. 2002 & 2008 - no prior radiation

• Gemcitabine (Gemzar) 900 mg/m2 IV over 90 minutes once daily on days 1 & 8, given first
• Docetaxel (Taxotere) 100 mg/m2 IV over 1 hour once on day 8, given second

21-day cycles x 6-8 cycles, given until progression of disease or unacceptable toxicity; Hensley, et al. 2008 did not specify a maximum number of cycles

Supportive medications:

• Dexamethasone (Decadron) 8 mg PO BID on days 7-9 (the day before, the day of, and day after docetaxel)
• Patients could receive diuretics at physician discretion for peripheral edema related to docetaxel
• One of the following growth factors (varies depending on reference):
  • G-CSF 150 mcg/m2 (dose rounded to 300 or 480 mcg) SC once daily on days 9-15 as primary neutropenia prophylaxis; could be stopped before day 15 if ANC >1200/uL on two separate measurements
  • Pegfilgrastim (Neulasta) 6 mg SC once on either day 9 or 10 (only one dose given)

Regimen #2, Hensley, et al. 2002 & 2008 - patients who received prior radiation

• Gemcitabine (Gemzar) 675 mg/m2 IV over 90 minutes once daily on days 1 & 8, given first
• Docetaxel (Taxotere) 75 mg/m2 IV over 1 hour once on day 8, given second

21-day cycles x 6-8 cycles, given until progression of disease or unacceptable toxicity; Hensley, et al. 2008 did not specify a maximum number of cycles

Supportive medications:

• Dexamethasone (Decadron) 8 mg PO BID on days 7-9 (the day before, the day of, and day after docetaxel)
• Patients could receive diuretics at physician discretion for peripheral edema related to docetaxel
• One of the following growth factors (varies depending on reference):
  • G-CSF 150 mcg/m2 (dose rounded to 300 or 480 mcg) SC once daily on days 9-15 as primary neutropenia prophylaxis; could be stopped before day 15 if ANC >1200/uL on two separate measurements
  • Pegfilgrastim (Neulasta) 6 mg SC once on either day 9 or 10 (only one dose given)

References

1. Hensley ML, Maki R, Venkatraman E, Geller G, Lovegren M, Aghajanian C, Sabbatini P, Tong W, Barakat R, Spriggs DR. Gemcitabine and docetaxel in patients with unresectable leiomyosarcoma: results of a phase II trial. J Clin Oncol. 2002 Jun 15;20(12):2824-31. link to original article contains verified protocol PubMed
2. Hensley ML, Blessing JA, Mannel R, Rose PG. Fixed-dose rate gemcitabine plus docetaxel as first-line therapy for metastatic uterine leiomyosarcoma: a Gynecologic Oncology Group phase II trial. Gynecol Oncol. 2008 Jun;109(3):329-34. link to original article contains verified protocol PubMed

Gemcitabine (Gemzar) & Vinorelbine (Navelbine)

Regimen, Dileo, et al. 2007

• Gemcitabine (Gemzar) 800 mg/m2 IV over 90 minutes once daily on days 1 & 8
• Vinorelbine (Navelbine) 25 mg/m2 IV over 10 minutes once daily on days 1 & 8

21-day cycles, given until progression of disease or unacceptable toxicity

Reference

1. Dileo P, Morgan JA, Zahrieh D, Desai J, Salesi JM, Harmon DC, Quigley MT, Polson K, Demetri GD, George S. Gemcitabine and vinorelbine combination chemotherapy for patients with advanced soft tissue sarcomas: results of a phase II trial. Cancer. 2007 May 1;109(9):1863-9. link to original article contains verified protocol PubMed

Giant-cell tumor of bone

Denosumab (Xgeva)

Regimen, Thomas, et. al 2010

• Denosumab (Xgeva) 120 mg SC once daily on days 1, 8, 15 of cycle 1; then on subsequent cycles Denosumab (Xgeva) 120 mg SC once on day 1

28-day cycles, given until complete tumor resection, progression of disease, or patient choice

Supportive medications:

• Calcium 500 mg PO once daily
• Vitamin D 400 IU PO once daily

References

1. Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010 Mar;11(3):275-80. link to original article contains verified protocol PubMed

GIST (Gastrointestinal Stromal Tumor) - neoadjuvant therapy

Imatinib (Gleevec)

Regimen, Eisenberg, et al. 2009 - RTOG 0132

• Imatinib (Gleevec) 600 mg PO once daily

given for 8-12 weeks prior to surgery, stopped on the day prior to surgery, resumed as soon as possible postoperatively, and continued for 2 years as postoperative adjuvant therapy

References

1. Eisenberg BL, Harris J, Blanke CD, Demetri GD, Heinrich MC, Watson JC, Hoffman JP, Okuno S, Kane JM, von Mehren M. Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): early results of RTOG 0132/ACRIN 6665. J Surg Oncol. 2009 Jan 1;99(1):42-7. link to original article contains verified protocol PubMed

GIST (Gastrointestinal Stromal Tumor) - adjuvant therapy

Imatinib (Gleevec)

Regimen #1, Joensuu, et al. 2012 - 3 years of treatment

Showed improved recurrence-free survival with 36 months of therapy as compared to 12 months of therapy.

• Imatinib (Gleevec) 400 mg PO once daily

36-month course, treatment started within 12 weeks after surgery

Regimen #2, Dematteo, et al. 2009 - 1 year of treatment

• Imatinib (Gleevec) 400 mg PO once daily

1-year course; treatment started within 12 weeks after surgery

References

1. Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, Patel S, McCarter MD, Polikoff JA, Tan BR, Owzar K; American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team. Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial. Lancet. 2009 Mar 28;373(9669):1097-104. link to original article contains verified protocol PubMed
2. Joensuu H, Eriksson M, Sundby Hall K, Hartmann JT, Pink D, Sch�tte J, Ramadori G, Hohenberger P, Duyster J, Al-Batran SE, Schlemmer M, Bauer S, Wardelmann E, Sarlomo-Rikala M, Nilsson B, Sihto H, Monge OR, Bono P, Kallio R, Vehtari A, Leinonen M, Alveg�rd T, Reichardt P. One vs three years of adjuvant imatinib for operable gastrointestinal stromal tumor: a randomized trial. JAMA. 2012 Mar 28;307(12):1265-72. doi: 10.1001/jama.2012.347. link to original article contains verified protocol PubMed

GIST (Gastrointestinal Stromal Tumor) - metastatic or unresectable disease

Imatinib (Gleevec)

Regimen #1, Blanke, et al. 2008

Standard dose therapy

• Imatinib (Gleevec) 400 mg PO once daily

given until progression of disease or unacceptable toxicity; patients who progressed on imatinib 400 mg PO once daily could receive high-dose therapy, as described below

High-dose therapy

• Imatinib (Gleevec) 400 mg PO twice per day

given until progression of disease or unacceptable toxicity

Regimen #2, Verweij, et al. 2003 & MetaGIST 2010

• Imatinib (Gleevec) 400 mg PO twice a day, taken after a meal

given until progression of disease or unacceptable toxicity

Regimen #3, Demetri, et al. 2002 & MetaGIST 2010

• Imatinib (Gleevec) 400 mg PO once daily, taken with food

References

1. Demetri GD, von Mehren M, Blanke CD, Van den Abbeele AD, Eisenberg B, Roberts PJ, Heinrich MC, Tuveson DA, Singer S, Janicek M, Fletcher JA, Silverman SG, Silberman SL, Capdeville R, Kiese B, Peng B, Dimitrijevic S, Druker BJ, Corless C, Fletcher CD, Joensuu H. Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N Engl J Med. 2002 Aug 15;347(7):472-80. link to original article contains verified protocol PubMed
2. Verweij J, van Oosterom A, Blay JY, Judson I, Rodenhuis S, van der Graaf W, Radford J, Le Cesne A, Hogendoorn PC, di Paola ED, Brown M, Nielsen OS. Imatinib mesylate (STI-571 Glivec, Gleevec) is an active agent for gastrointestinal stromal tumours, but does not yield responses in other soft-tissue sarcomas that are unselected for a molecular target. Results from an EORTC Soft Tissue and Bone Sarcoma Group phase II study. Eur J Cancer. 2003 Sep;39(14):2006-11. link to original article contains verified protocol PubMed
3. Blanke CD, Rankin C, Demetri GD, Ryan CW, von Mehren M, Benjamin RS, Raymond AK, Bramwell VH, Baker LH, Maki RG, Tanaka M, Hecht JR, Heinrich MC, Fletcher CD, Crowley JJ, Borden EC. Phase III randomized, intergroup trial assessing imatinib mesylate at two dose levels in patients with unresectable or metastatic gastrointestinal stromal tumors expressing the kit receptor tyrosine kinase: S0033. J Clin Oncol. 2008 Feb 1;26(4):626-32. doi: 10.1200/JCO.2007.13.4452. link to original article contains verified protocol PubMed
4. Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST). Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1,640 patients. J Clin Oncol. 2010 Mar 1;28(7):1247-53. doi: 10.1200/JCO.2009.24.2099. Epub 2010 Feb 1. link to original article PubMed

Regorafenib (Stivarga)

Regimen - GRID

Patients in this study already had treatment failure with imatinib and sunitinib.

• Regorafenib (Stivarga) 160 mg PO once daily on days 1-21

28-day cycles, given until progression of disease or unacceptable toxicity

References

1. Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, Badalamenti G, Blackstein M, Le Cesne A, Sch�ffski P, Maki RG, Bauer S, Nguyen BB, Xu J, Nishida T, Chung J, Kappeler C, Kuss I, Laurent D, Casali PG; GRID study investigators. Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013 Jan 26;381(9863):295-302. doi: 10.1016/S0140-6736(12)61857-1. Epub 2012 Nov 22. link to original article contains verified protocol PubMed

Sunitinib (Sutent)

Regimen

Patients in this study had treatment failure with imatinib.

• Sunitinib (Sutent) 50 mg PO once daily on days 1-28
  • Dose may be decreased to 37.5 mg or 25 mg depending on tolerability

42-day cycles, given until progression of disease or unacceptable toxicity

References

1. Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet. 2006 Oct 14;368(9544):1329-38. link to original article contains verified protocol PubMed
2. Prior JO, Montemurro M, Orcurto MV, Michielin O, Luthi F, Benhattar J, Guillou L, Elsig V, Stupp R, Delaloye AB, Leyvraz S. Early prediction of response to sunitinib after imatinib failure by 18F-fluorodeoxyglucose positron emission tomography in patients with gastrointestinal stromal tumor. J Clin Oncol. 2009 Jan 20;27(3):439-45. doi: 10.1200/JCO.2008.17.2742. Epub 2008 Dec 8. link to original article contains verified protocol PubMed

Temozolomide (Temodar)

• Regimen is the same as Temozolomide (Temodar) single-agent therapy in soft tissue sarcoma, Garcia del Muro, et al. 2005

Angiosarcoma

Bevacizumab (Avastin)

Regimen, Agulnik et al. 2013

• Bevacizumab (Avastin) 15 mg/kg IV once on day 1

21-day cycles, given until progression of disease, intolerance, unacceptable toxicity, patient refusal, or physician discretion

References

1. Agulnik M, Yarber JL, Okuno SH, von Mehren M, Jovanovic BD, Brockstein BE, Evens AM, Benjamin RS. An open-label, multicenter, phase II study of bevacizumab for the treatment of angiosarcoma and epithelioid hemangioendotheliomas. Ann Oncol. 2013 Jan;24(1):257-63. doi: 10.1093/annonc/mds237. link to original article contains verified protocol PubMed

Paclitaxel (Taxol)

Regimen, Penel et al. 2008 - ANGIOTAX

• Paclitaxel (Taxol) 80 mg/m2 IV over 60 minutes once daily on days 1, 8, 15

28-day cycles x 6 cycles, given until progression of disease or unacceptable toxicity

Supportive medications:

• Dexamethasone (Decadron) 8 mg IV once prior to paclitaxel
• Cimetidine (Tagamet) 200 mg IV once prior to paclitaxel
• Dexchlorpheniramine (note: was spelled as dexchloropheramine in the Penel, et al. 2008) (Polaramine) 5 mg IV once prior to paclitaxel
• "Standard antiemetics (mainly metoclopramide) were prescribed as clinically indicated by the treating physician"

References

1. Penel N, Bui BN, Bay JO, Cupissol D, Ray-Coquard I, Piperno-Neumann S, Kerbrat P, Fournier C, Taieb S, Jimenez M, Isambert N, Peyrade F, Chevreau C, Bompas E, Brain EG, Blay JY. Phase II trial of weekly paclitaxel for unresectable angiosarcoma: the ANGIOTAX Study. J Clin Oncol. 2008 Nov 10;26(32):5269-74. doi: 10.1200/JCO.2008.17.3146. Epub 2008 Sep 22. link to original article contains verified protocol PubMed

HIV/AIDS-associated Kaposi Sarcoma

Liposomal Daunorubicin

Regimen, Gill et al. 1996

• Liposomal daunorubicin (DaunoXome) 40 mg/m2 IV over 30-60 minutes every 2 weeks

14-day cycles x minimum of 2 cycles, given until CR, unacceptable toxicity, disease progression, patient refusal, or death

Supportive medications:

• "No routine premedication was established by the protocol, but it could be provided at the discretion of the investigator"

References

1. Gill PS, Wernz J, Scadden DT, Cohen P, Mukwaya GM, von Roenn JH, Jacobs M,Kempin S, Silverberg I, Gonzales G, Rarick MU, Myers AM, Shepherd F, Sawka C, Pike MC, Ross ME. Randomized phase III trial of liposomal daunorubicin versus doxorubicin, bleomycin, and vincristine in AIDS-related Kaposi's sarcoma. J Clin Oncol. 1996 Aug;14(8):2353-64. link to original article contains verified protocol PubMed

Etoposide (Vepesid)

Regimen, Evans et al. 2002

• Etoposide (Vepesid) 50 mg PO daily, days 1-7

14-day cycles

References

1. Evans SR, Krown SE, Testa MA, Cooley TP, Von Roenn JH. Phase II evaluation of low-dose oral etoposide for the treatment of relapsed or progressive AIDS-related Kaposi's sarcoma: an AIDS Clinical Trials Group clinical study. J Clin Oncol. 2002 Aug 1;20(15):3236-41. link to original article contains verified protocol PubMed