Difference between revisions of "Vincristine (Oncovin)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
<div style="column-count:3;-moz-column-count:3;-webkit-column-count:3"> | <div style="column-count:3;-moz-column-count:3;-webkit-column-count:3"> | ||
| − | |||
*[[Adult T-cell leukemia-lymphoma]] | *[[Adult T-cell leukemia-lymphoma]] | ||
*[[Anaplastic large cell lymphoma]] | *[[Anaplastic large cell lymphoma]] | ||
| − | *[[ | + | *[[B-cell acute lymphoblastic leukemia]] |
*[[Burkitt lymphoma]] | *[[Burkitt lymphoma]] | ||
*[[Central nervous system (CNS) cancer]] | *[[Central nervous system (CNS) cancer]] | ||
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*[[CNS lymphoma]] | *[[CNS lymphoma]] | ||
*[[Diffuse large B-cell lymphoma]] | *[[Diffuse large B-cell lymphoma]] | ||
| + | *[[Ewing's sarcoma]] | ||
*[[Extranodal NK/T-cell lymphoma, nasal type]] | *[[Extranodal NK/T-cell lymphoma, nasal type]] | ||
*[[Follicular lymphoma]] | *[[Follicular lymphoma]] | ||
| + | *[[Germ cell tumors]] | ||
*[[HIV-associated lymphoma]] | *[[HIV-associated lymphoma]] | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
| Line 29: | Line 30: | ||
*[[Penile cancer]] | *[[Penile cancer]] | ||
*[[Peripheral T-cell lymphoma]] | *[[Peripheral T-cell lymphoma]] | ||
| + | *[[Post-transplant lymphoproliferative disorder]] | ||
| + | *[[Primary mediastinal B-cell lymphoma]] | ||
*[[Sarcoma]] | *[[Sarcoma]] | ||
*[[Small cell lung cancer]] | *[[Small cell lung cancer]] | ||
| + | *[[T-cell acute lymphoblastic leukemia]] | ||
*[[Thrombotic thrombocytopenic purpura]] | *[[Thrombotic thrombocytopenic purpura]] | ||
*[[Thymoma]] | *[[Thymoma]] | ||
| + | *[[Transformed lymphoma]] | ||
*[[Transplant conditioning regimens]] | *[[Transplant conditioning regimens]] | ||
| + | *[[Waldenström macroglobulinemia]] | ||
</div> | </div> | ||
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[[Category:Vinca alkaloids]] | [[Category:Vinca alkaloids]] | ||
| − | |||
[[Category:Adult T-cell leukemia-lymphoma medications]] | [[Category:Adult T-cell leukemia-lymphoma medications]] | ||
| − | |||
[[Category:Anaplastic large cell lymphoma medications]] | [[Category:Anaplastic large cell lymphoma medications]] | ||
| − | [[Category: | + | [[Category:B-cell acute lymphoblastic leukemia medications]] |
[[Category:Burkitt lymphoma medications]] | [[Category:Burkitt lymphoma medications]] | ||
[[Category:Central nervous system (CNS) cancer medications]] | [[Category:Central nervous system (CNS) cancer medications]] | ||
| Line 145: | Line 149: | ||
[[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | [[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| + | [[Category:Ewing's sarcoma medications]] | ||
[[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | [[Category:Extranodal NK/T-cell lymphoma, nasal type medications]] | ||
[[Category:Follicular lymphoma medications]] | [[Category:Follicular lymphoma medications]] | ||
| + | [[Category:Germ cell tumors medications]] | ||
[[Category:HIV-associated lymphoma medications]] | [[Category:HIV-associated lymphoma medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
| Line 157: | Line 163: | ||
[[Category:Penile cancer medications]] | [[Category:Penile cancer medications]] | ||
[[Category:Peripheral T-cell lymphoma medications]] | [[Category:Peripheral T-cell lymphoma medications]] | ||
| + | [[Category:Post-transplant lymphoproliferative disorder medications]] | ||
| + | [[Category:Primary mediastinal B-cell lymphoma medications]] | ||
[[Category:Sarcoma medications]] | [[Category:Sarcoma medications]] | ||
[[Category:Small cell lung cancer medications]] | [[Category:Small cell lung cancer medications]] | ||
| + | [[Category:T-cell acute lymphoblastic leukemia medications]] | ||
[[Category:Thrombotic thrombocytopenic purpura medications]] | [[Category:Thrombotic thrombocytopenic purpura medications]] | ||
[[Category:Thymoma medications]] | [[Category:Thymoma medications]] | ||
| + | [[Category:Transformed lymphoma medications]] | ||
[[Category:Transplant medications]] | [[Category:Transplant medications]] | ||
| + | [[Category:Waldenström macroglobulinemia medications]] | ||
[[Category:Drugs FDA approved in 1963]] | [[Category:Drugs FDA approved in 1963]] | ||
[[Category:WHO Essential Cancer Medicine]] | [[Category:WHO Essential Cancer Medicine]] | ||
Revision as of 02:01, 20 July 2017
General information
Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Adult T-cell leukemia-lymphoma
- Anaplastic large cell lymphoma
- B-cell acute lymphoblastic leukemia
- Burkitt lymphoma
- Central nervous system (CNS) cancer
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- CNS lymphoma
- Diffuse large B-cell lymphoma
- Ewing's sarcoma
- Extranodal NK/T-cell lymphoma, nasal type
- Follicular lymphoma
- Germ cell tumors
- HIV-associated lymphoma
- Hodgkin lymphoma
- Hodgkin lymphoma, nodular lymphocyte-predominant
- Mantle cell lymphoma
- Marginal zone lymphoma
- Mediastinal gray-zone lymphoma
- Multiple myeloma
- Neuroendocrine tumors
- Penile cancer
- Peripheral T-cell lymphoma
- Post-transplant lymphoproliferative disorder
- Primary mediastinal B-cell lymphoma
- Sarcoma
- Small cell lung cancer
- T-cell acute lymphoblastic leukemia
- Thrombotic thrombocytopenic purpura
- Thymoma
- Transformed lymphoma
- Transplant conditioning regimens
- Waldenström macroglobulinemia
Notable side effects
- Neuropathy [3]
Patient drug information
- Vincristine (Oncovin) patient drug information (Chemocare)[4]
- Vincristine (Oncovin) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 7/10/1963: Initial FDA approval
Also known as
Precise Name: vinCRIStine Sulfate (RXCUI 11203)
| Synonyms | |||||||
|---|---|---|---|---|---|---|---|
| Alcrist | Biocrist | Biocrystin | Cellcristin | Citomid | Citomid RU | Crivosin | Cytomid |
| Farmistin CS | Fauldvincri | Krebin | Kyocristine | Nevexitin | Oncocristin AQ | Oncovin ELI Lilly | Oncovin INJ.LSG. |
| Oncovin Yamakawa | Onkocristin | P&U Vincristine | Pericristine | Pharmacristine | Tecnocris | Trav Vincristine | Vero Vincristin |
| Vincasar | Vincasar PFS | Vinces | Vincosid | Vincran | Vincrex | Vincrifil | Vincrin |
| Vincrisin | Vincrisol | Vincristin | Vincristina | Vincristina Faulding | Vincristina Filaxis | Vincristina Martian | Vincristin Biosyn |
| Vincristin CS | Vincristine | Vincristine Abic | Vincristine Comp | Vincristine DBL | Vincristine Lederle | Vincristine Mayne | Vincristine Mayne Pharma ( BEN ) |
| Vincristine Pharmachemie | Vincristinesulfaat | Vincristine Sulfate | Vincristine Sulfate Synthelabo | Vincristine Sulp | Vincristine Sulphate | Vincristine Teva | Vincristinsulfat |
| Vincristin Sulfate | Vincristinum | Vincrisul | Vinracin | Vinracine | Vinstin | Vintec | |
References
- ↑ 1.0 1.1 Vincristine (Oncovin) package insert
- ↑ Vincristine (Oncovin) package insert (locally hosted backup)
- ↑ Broyl A, Corthals SL, Jongen JL, van der Holt B, Kuiper R, de Knegt Y, van Duin M, el Jarari L, Bertsch U, Lokhorst HM, Durie BG, Goldschmidt H, Sonneveld P. Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. Epub 2010 Sep 21. link to original article contains verified protocol PubMed
- ↑ Vincristine (Oncovin) patient drug information (Chemocare)
- ↑ Vincristine (Oncovin) patient drug information (UpToDate)
Categories:
- Drug index
- Chemotherapy
- Intravenous chemotherapy
- Vesicant chemotherapy
- Microtubule inhibitors
- Vinca alkaloids
- Adult T-cell leukemia-lymphoma medications
- Anaplastic large cell lymphoma medications
- B-cell acute lymphoblastic leukemia medications
- Burkitt lymphoma medications
- Central nervous system (CNS) cancer medications
- Central nervous system (CNS) lymphoma medications
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Diffuse large B-cell lymphoma medications
- Ewing's sarcoma medications
- Extranodal NK/T-cell lymphoma, nasal type medications
- Follicular lymphoma medications
- Germ cell tumors medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Hodgkin lymphoma, nodular lymphocyte-predominant medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Mediastinal gray-zone lymphoma medications
- Multiple myeloma medications
- Neuroendocrine tumor medications
- Penile cancer medications
- Peripheral T-cell lymphoma medications
- Post-transplant lymphoproliferative disorder medications
- Primary mediastinal B-cell lymphoma medications
- Sarcoma medications
- Small cell lung cancer medications
- T-cell acute lymphoblastic leukemia medications
- Thrombotic thrombocytopenic purpura medications
- Thymoma medications
- Transformed lymphoma medications
- Transplant medications
- Waldenström macroglobulinemia medications
- Drugs FDA approved in 1963
- WHO Essential Cancer Medicine