Doxorubicin (Adriamycin)

General information

Class/mechanism: Anthracycline; binds and intercalates into DNA, inhibiting nucleotide replication and DNA/RNA polymerase activity. Intercalation of DNA triggers DNA cleavage via topoisomerase II. Toxic effects on organs may be related to cell membrane lipid binding activities; enzymatic electron reduction of doxorubicin creates reactive species, e.g. hydroxyl free radicals OH-, which has been implicated in cardiotoxicity by means of Cu (II) and Fe (III) reduction.^[1]^[2]
Route: IV
Extravasation: vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.^[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

8/7/1974: Initial FDA approval
5/8/2003: Earliest date with label information at Drugs @ FDA: "Doxorubicin has been used successfully to produce regression in disseminated neoplastic conditions such as acute lymphoblastic leukemia, acute myeloblastic leukemia, Wilms’ tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin’s disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types. Doxorubicin is also indicated for use as a component of adjuvant therapy in women with evidence of axillary lymph node involvement following resection of primary breast cancer.

Also known as

Synonyms
Adriablastina	Adriacept	Adriacin	Adriamycin HS	Adriamycin PFS	Adriamycin R-D	Adriamycin R.D.F	Adriamycin RDF
Adriblastin	Adriblastina	Adriblastina DR	Adriblastina R.D.	Adriblastina R.T.U.	Adriblastina RD	Adriblastina RTU	Adriblastine
Adriblastine RTU	Adriblastin PFS	Adriblastin RD	Adricept	Adricin	Adrim	Adrimedac	Adrosal
Antraciclin	Biorrub	Biorubina	Cadria	Carcinocin	Cloridrato DE	Doxorrubicina Colhidrol	Daxotel
Deldoxin	Dicladox	Dobicin	Dobixin	Doxo	Doxobin	Doxo Cell	Doxocris
Doxokebir	Doxolem	Doxolem RU	Doxonolver	Doxor	Doxorrubicina	Doxoruben	Doxorubicina
Doxorubicina Asofarma	Doxorubicina Ferrer	Doxorubicina Filaxis	Doxorubicina Gador	Doxorubicina Servycal	Doxorubicina Tedec	Doxorubicin Bigmar	Doxorubicin Comp
Doxorubicin DBL	Doxorubicine	Doxorubicin Ebewe	Doxorubicine Bristol	Doxorubicine Dakota	Doxorubicine G GAM	Doxorubicine HCl Eurocept	Doxorubicine Hydrochloride
Doxorubicine Sandoz HCl	Doxorubicine Teva	Doxorubicin FOT	Doxorubicin Funk	Doxorubicin HCl	Doxorubicin Hydrochloride	Doxorubicin KMP	Doxorubicin Meda
Doxorubicin Pharmachemie	Doxorubicin Teva	Doxorubicinum	Doxorubin	Doxotec	Doxtie	Duxocin	Evacet
Farmiblastina	Fauldoxo	Flavicina	hydroxydaunorubicin	Ifadox,L-Doxorubicin	Lipodox	Lyphidox	Myocet
Nagun	Neoxane	Nuaze	Oncodria	Onkodox	Onkostatil	Pallagicin	Ranxas
Rastocin	Ribodoxo	Ribodoxo-L	Roxorin	Rubex	Trav Doxorubicin	Urokit Doxo Cell Loesung	Varidoxo
Zodox

References

[insert-1] 1.0 ^1.1 ^1.2 Doxorubicin (Adriamycin) package insert

[2] Doxorubicin (Adriamycin) package insert (locally hosted backup)

[3] Doxorubicin (Adriamycin) patient drug information (Chemocare)

[4] Doxorubicin (Adriamycin) patient drug information (UpToDate)

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