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The "How I Treat" series has been published by Blood for several decades and covers a wide variety of topics in malignant and classical hematology. While these articles are not considered to be formal guidelines, they are considered highly reputable sources of expert opinion. They cover topics ranging from commonly encountered hematologic conditions with a large evidence base, to very rare conditions with only case reports to guide treatment. The purpose of this page is to consolidate the links to all known published How I Treat articles.

In the first two sections (malignant hematology and classical hematology), articles are presented by condition, in reverse chronological order. In the third section, articles are gathered under "special considerations" such as pregnancy and hematologic disease. Given the rapid change in evidence in many areas of hematology, readers are encouraged to consider any article published 5+ years ago to be for historical purposes, only.

Note: this page is currently under construction.

Malignant hematology

Myeloid neoplasms

Lymphoid neoplasms

Adult T-cell leukemia-lymphoma (ATLL)

2021: Cook & Phillips How I treat adult T-cell leukemia/lymphoma PubMed

Anaplastic large cell lymphoma

2018: Metha-Shah et al. How I treat breast implant-associated anaplastic large cell lymphoma PubMed

Burkitt lymphoma (BL)

2018: Gopal & Gross. How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa PubMed
2014: Jacobson & LaCasce. How I treat Burkitt lymphoma in adults PubMed

Castleman disease

2010: Bower. How I treat HIV-associated multicentric Castleman disease PubMed

Chronic lymphocytic leukemia (CLL/SLL)

2021: Lew et al. How I treat chronic lymphocytic leukemia after venetoclax
2019: Stephens & Byrd. How I manage ibrutinib intolerance and complications in patients with chronic lymphocytic leukemia
2018: Brown. How I treat CLL patients with ibrutinib PubMed
2018: Gribben. How and when I do allogeneic transplant in CLL PubMed
2017: Woyach. How I manage ibrutinib-refractory chronic lymphocytic leukemia PubMed
2009: Gribben. How I treat CLL up front PubMed

CNS lymphoma

2017: Chin & Cheah. How I treat patients with aggressive lymphoma at high risk of CNS relapse PubMed
2013: Rubenstein et al. How I treat CNS lymphomas PubMed

Cutaneous T-cell lymphoma (CTCL)

2019: Shinohara & Shustov How I treat primary cutaneous CD30 + lymphoproliferative disorders

Hodgkin lymphoma

2021: Epperla & Herrera. How I incorporate novel agents into the treatment of classical Hodgkin lymphoma
2020: Eichenauer & Engert. How I treat nodular lymphocyte-predominant Hodgkin Lymphoma

Diffuse large B-cell lymphoma (DLBCL)

2023: Lugtenburg & Mutsaers. How I treat older patients with DLBCL in the frontline setting PubMed

Follicular lymphoma (FL)

2019: Casulo & Barr. How I treat early-relapsing follicular lymphoma PubMed

High-grade B-cell lymphoma (HGBL)

2017: Friedberg. How I treat double-hit lymphoma PubMed

Large granular lymphocytic leukemia (T-LGL)

2011: Lamy & Loughran. How I treat LGL leukemia PubMed

NK- and T-cell lymphoma

2013: Tse & Kwong. How I treat NK/T-cell lymphomas PubMed

Prolymphocytic leukemia (T-PLL)

2012: Dearden. How I treat prolymphocytic leukemia PubMed

Waldenström macroglobulinemia (WM)

2019: Dimopoulos & Kastritis. How I treat Waldenström macroglobulinemia PubMed

Plasma cell dyscrasias

Light-chain (AL) amyloidosis

2022: Palladini & Merlini. How I treat AL amyloidosis
2012: Leung et al. How I treat amyloidosis: the importance of accurate diagnosis and amyloid typing PubMed

Multiple myeloma

2023: van de Donk. How We Manage Newly Diagnosed Multiple Myeloma With Circulating Tumor Cells
2022: Zamagni et al. How I treat high-risk multiple myeloma
2022: Kastritis et al. How I treat relapsed multiple myeloma
2022: Vaxman & Gertz. How I approach smoldering multiple myeloma

Histiocytic disorders

Hemophagocytic lymphohistiocytosis (HLH)

2015: Schram & Berliner. How I treat hemophagocytic lymphohistiocytosis in the adult patient PubMed

Classical hematology

Hemostasis and thrombosis

Acquired thrombotic thrombocytopenic purpura (aTTP)

2022: Akwaa et al. How I treat immune-mediated thrombotic thrombocytopenic purpura after hospital discharge
2020: Ferrari & Peyvandi. How I treat thrombotic thrombocytopenic purpura in pregnancy

Antiphospholipid antibody syndrome (APS)

2021: Cohen & Isenberg. How I treat anticoagulant-refractory thrombotic antiphospholipid syndrome PubMed

Arterial thromboembolism (ATE)

2020: May & Moll. How I treat unexplained arterial thrombosis

Hemophilia

2020: Leebeek et al. How I manage pregnancy in carriers of hemophilia and patients with von Willebrand disease
2019: Young. How I treat children with haemophilia and inhibitors

Thrombotic microangiopathy (TMA)

2023: Doreille et al. How I treat thrombotic microangiopathy in the era of rapid genomics
2021: Thomas & Scully. How I treat microangiopathic hemolytic anemia in patients with cancer

Venous thromboembolism (VTE)

2022: Schmidt & Lee. How I treat and prevent venous thrombotic complications in patients with lymphoma
2020: Klok & Huisman. How I assess and manage the risk of bleeding in patients treated for venous thromboembolism
2020: Middeldorp & Ganzevoort. How I treat venous thromboembolism in pregnancy
2020: Wang & Carrier. How I treat obese patients with oral anticoagulants
2019: Pabinger & Thaler. How I treat patients with hereditary antithrombin deficiency
2019: Chan & Eikelbloom. How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism
2019: Kraaijpoel & Carrier. How I treat cancer-associated venous thromboembolism
2018: Shet & Wun. How I diagnose and treat venous thromboembolism in sickle cell disease

von Willebrand disease (vWD)

2020: Biguzzi et al. How I treat gastrointestinal bleeding in congenital and acquired von Willebrand disease
2020: Leebeek et al. How I manage pregnancy in carriers of hemophilia and patients with von Willebrand disease
2019: Lavin & O'Donnell. How I treat low von Willebrand factor levels

Cytopenias

Anemia

2021: Gurnari & Maciejewski. How I manage acquired pure red cell aplasia in adults
2020: Anand & Gupta. How I treat anemia in heart failure
2020: Fishbane & Coyne. How I treat renal anemia
2020: Gilreath & Rodgers. How I treat cancer-associated anemia
2020: Shander et al. How I treat anemia in the perisurgical setting
2014: Hershko & Camaschella. How I treat unexplained refractory iron deficiency anemia

Autoimmune cytopenia

2022: Porpaczy & Jäger. How I manage autoimmune cytopenias in patients with lymphoid cancer PubMed

Immune thrombocytopenia (ITP)

2021: Ghanima et al. How I treat primary ITP in adult patients who are unresponsive to or dependent on corticosteroid treatment

Thrombocytopenia and platelet dysfunction

2023: Stanworth & Mumford How I diagnose and treat neonatal thrombocytopenia PubMed
2022: Stanworth & Shah How I use platelet transfusions PubMed
2022: Fiore et al. How I manage pregnancy in women with Glanzmann thrombasthenia
2021: Kyrle & Eichinger How I manage cyclic thrombocytopenia

Hemoglobinopathies

Beta thalassemia

2018: Taher & Cappellini. How I manage medical complications of β-thalassemia in adults PubMed

Sickle cell disease

2019: Stenger et al. How I treat sickle cell disease with hematopoietic cell transplantation
2018: Shet & Wun. How I diagnose and treat venous thromboembolism in sickle cell disease
2018: Thein & Howard. How I treat the older adult with sickle cell disease

Hemolytic disorders

Cold agglutinin disease (CAD)

2021: Berentsen. How I treat cold agglutinin disease

Atypical hemolytic uremic syndrome (aHUS)

2023: Fakhouri et al. How I diagnose and treat atypical hemolytic uremic syndrome PubMed

Paroxysmal nocturnal hemoglobinuria (PNH)

2021: Brodsky. How I treat paroxysmal nocturnal hemoglobinuria

Warm autoimmune hemolytic anemia (WAIHA)

2021: Barcellini & Fattizzo. How I treat warm autoimmune hemolytic anemia

Special considerations

Age-based recommendations

The majority of How I Treat articles focus on "standard" adults; below, articles that focus on other age populations are concatenated.

Neonates

2023: Stanworth & Mumford How I diagnose and treat neonatal thrombocytopenia PubMed

Children

2023: Myers et al. How I use risk factors for success or failure of CD19 CAR T cells to guide management of children and AYA with B-cell ALL PubMed
2023: Si Lim et al. How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults PubMed
2020: Teachey & O'Connor How I treat newly diagnosed T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma in children PubMed
2019: Hijiya & Suttorp. How I treat chronic myeloid leukemia in children and adolescents
2018: Gopal & Gross. How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa PubMed
2012: Locatelli et al. How I treat relapsed childhood acute lymphoblastic leukemia PubMed

Adolescents and young adults (AYA)

2023: Si Lim et al. How I treat newly diagnosed and refractory T-cell acute lymphoblastic lymphoma in children and young adults PubMed
2019: Hijiya & Suttorp. How I treat chronic myeloid leukemia in children and adolescents
2019: Young. How I treat children with haemophilia and inhibitors
2018: Gopal & Gross. How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa PubMed
2015: Curran & Stock. How I treat acute lymphoblastic leukemia in older adolescents and young adults PubMed

Older adults

2023: Lugtenburg & Mutsaers How I treat older patients with DLBCL in the frontline setting PubMed
2019: Chan & Eikelbloom. How I manage anticoagulant therapy in older individuals with atrial fibrillation or venous thromboembolism
2018: Thein & Howard. How I treat the older adult with sickle cell disease
2014: Ossenkoppele & Löwenberg. How I treat the older patient with acute myeloid leukemia PubMed
2013: Gökbuget. How I treat older patients with ALL PubMed

Complications of treatment

Immune effector cells toxicity management

2023: Gutierrez et al. How I approach optimization of patients at risk of cardiac and pulmonary complications after CAR T-cell therapy PubMed
2023: Jain et al. How I treat refractory CRS and ICANS after CAR T-cell therapy PubMed
2023: Jain et al. How I treat cytopenias after CAR T-cell therapy PubMed
2023: Santomasso et al. How I treat unique and difficult-to-manage cases of CAR T-cell therapy-associated neurotoxicity PubMed

Infectious complications

2016: El Chaer et al. How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients PubMed
2016: Waghmare et al. How I treat respiratory viral infections in the setting of intensive chemotherapy or hematopoietic cell transplantation PubMed
2014: Nucci & Anaissie. How we treat invasive fungal diseases in patients with acute leukemia: the importance of an individualized approach PubMed

Pregnancy

2022: Fiore et al. How I manage pregnancy in women with Glanzmann thrombasthenia
2020: Ferrari & Peyvandi. How I treat thrombotic thrombocytopenic purpura in pregnancy
2020: Leebeek et al. How I manage pregnancy in carriers of hemophilia and patients with von Willebrand disease
2020: Middeldorp & Ganzevoort. How I treat venous thromboembolism in pregnancy

Regional considerations

2018: Gopal & Gross. How I treat Burkitt lymphoma in children, adolescents, and young adults in sub-Saharan Africa PubMed

Transplatation

Allogeneic HSCT

2023: DeFilipp & Chen. How I treat with maintenance therapy after allogeneic HCT PubMed
2020: Puerta-Alcalde et al. How I perform hematopoietic stem cell transplantation on patients with a history of invasive fungal disease PubMed
2019: McCurdy & Luznik. How we perform haploidentical stem cell transplantation with posttransplant cyclophosphamide PubMed
2018: Gribben. How and when I do allogeneic transplant in CLL PubMed
2017: Williams. How I treat bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation PubMed
2016: El Chaer et al. How I treat resistant cytomegalovirus infection in hematopoietic cell transplantation recipients PubMed
2012: Wingard et al. How I manage pulmonary nodular lesions and nodular infiltrates in patients with hematologic malignancies or undergoing hematopoietic cell transplantation PubMed

Graft versus host disease (GVHD)

2023: Cooper & Abkowitz. How I diagnose and treat acute graft-versus-host disease after solid organ transplantation
2023: Rimando et al. How I prevent GVHD in high-risk patients: posttransplant cyclophosphamide and beyond
2020: Martin. How I treat steroid-refractory acute graft-versus-host disease PubMed
2019: Sarantopoulos et al. How I treat refractory chronic graft-versus-host disease
2016: McDonald. How I treat acute graft-versus-host disease of the gastrointestinal tract and the liver PubMed
2014: Flowers & Martin. How we treat chronic graft-versus-host disease
2012: Treister et al. How we treat oral chronic graft-versus-host disease PubMed
2007: Deeg. How I treat refractory acute GVHD PubMed

@@ Line 92: / Line 92: @@
 *'''2019:''' Shinohara & Shustov [https://doi.org/10.1182/blood.2019000785 How I treat primary cutaneous CD30 + lymphoproliferative disorders]
-===Hodgkin lymphoma===
+===[[Classical Hodgkin lymphoma|Hodgkin lymphoma]]===
-*'''2021:''' Epperla & Herrera [https://doi.org/10.1182/blood.2020007900 How I incorporate novel agents into the treatment of classical Hodgkin lymphoma]
+*'''2021:''' Epperla & Herrera. [https://doi.org/10.1182/blood.2020007900 How I incorporate novel agents into the treatment of classical Hodgkin lymphoma]
-*'''2020:''' Eichenauer & Engert [https://doi.org/10.1182/blood.2019004044 How I treat nodular lymphocyte-predominant Hodgkin Lymphoma]
+*'''2020:''' Eichenauer & Engert. [https://doi.org/10.1182/blood.2019004044 How I treat nodular lymphocyte-predominant Hodgkin Lymphoma]
 ===[[Diffuse large B-cell lymphoma|Diffuse large B-cell lymphoma (DLBCL)]]===
-*'''2023:''' Lugtenburg & Mutsaers [https://doi.org/10.1182/blood.2020008239 How I treat older patients with DLBCL in the frontline setting] [https://pubmed.ncbi.nlm.nih.gov/36413153/ PubMed]
+*'''2023:''' Lugtenburg & Mutsaers. [https://doi.org/10.1182/blood.2020008239 How I treat older patients with DLBCL in the frontline setting] [https://pubmed.ncbi.nlm.nih.gov/36413153/ PubMed]
 ===[[Follicular lymphoma|Follicular lymphoma (FL)]]===
-*'''2019:''' Casulo & Barr [https://doi.org/10.1182/blood-2018-08-822148 How I treat early-relapsing follicular lymphoma] [https://pubmed.ncbi.nlm.nih.gov/30700421/ PubMed]
+*'''2019:''' Casulo & Barr. [https://doi.org/10.1182/blood-2018-08-822148 How I treat early-relapsing follicular lymphoma] [https://pubmed.ncbi.nlm.nih.gov/30700421/ PubMed]
+===[[High-grade B-cell lymphoma|High-grade B-cell lymphoma (HGBL)]]===
+*'''2017:''' Friedberg. [https://doi.org/10.1182/blood-2017-04-737320 How I treat double-hit lymphoma] [https://pubmed.ncbi.nlm.nih.gov/28600333/ PubMed]
 ===[[Large granular lymphocytic leukemia|Large granular lymphocytic leukemia (T-LGL)]]===
@@ Line 106: / Line 109: @@
 ===[[NK- and T-cell lymphoma]]===
-*'''2013:''' Tse & Kwong [http://www.bloodjournal.org/content/121/25/4997.long How I treat NK/T-cell lymphomas] [https://pubmed.ncbi.nlm.nih.gov/23652805/ PubMed]
+*'''2013:''' Tse & Kwong. [http://www.bloodjournal.org/content/121/25/4997.long How I treat NK/T-cell lymphomas] [https://pubmed.ncbi.nlm.nih.gov/23652805/ PubMed]
 ===[[T-cell prolymphocytic leukemia|Prolymphocytic leukemia (T-PLL)]]===
-*'''2012:''' Dearden [https://doi.org/10.1182/blood-2012-01-380139 How I treat prolymphocytic leukemia] [https://pubmed.ncbi.nlm.nih.gov/22649104/ PubMed]
+*'''2012:''' Dearden. [https://doi.org/10.1182/blood-2012-01-380139 How I treat prolymphocytic leukemia] [https://pubmed.ncbi.nlm.nih.gov/22649104/ PubMed]
 ===[[Waldenström macroglobulinemia|Waldenström macroglobulinemia (WM)]]===

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