Difference between revisions of "Cyclophosphamide (Cytoxan)"

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Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.<ref name="insert">[http://packageinserts.bms.com/pi/pi_cytoxan.pdf Cyclophosphamide (Cytoxan) package insert]</ref><ref>[[Media:Cyclophosphamide.pdf | Cyclophosphamide (Cytoxan) package insert (locally hosted backup)]]</ref>
 
Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.<ref name="insert">[http://packageinserts.bms.com/pi/pi_cytoxan.pdf Cyclophosphamide (Cytoxan) package insert]</ref><ref>[[Media:Cyclophosphamide.pdf | Cyclophosphamide (Cytoxan) package insert (locally hosted backup)]]</ref>
 
<br>Route: IV, PO
 
<br>Route: IV, PO
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<br>Extravasation: [[irritant]], n/a
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<br>Extravasation: [[irritant]] or [[neutral]], depending on reference; n/a
  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/cytoxan-cyclophosphamide-342214 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/cytoxan-cyclophosphamide-342214 Medscape],[http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
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[[Category:Intravenous chemotherapy]]
 
[[Category:Intravenous chemotherapy]]
 
[[Category:Irritant chemotherapy]]
 
[[Category:Irritant chemotherapy]]
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[[Category:Neutral chemotherapy]]
 
[[Category:Oral chemotherapy]]
 
[[Category:Oral chemotherapy]]
  

Revision as of 20:42, 23 April 2017

General information

Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.[1][2]
Route: IV, PO
Extravasation: irritant or neutral, depending on reference; n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape,UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 11/16/1959: initial FDA approval

Also known as

Synonyms
Alkyloxan Biodoxan Carloxan Ciclofosfamida Ciclofosfamida Filaxis Ciclofosfamida Martian Ciclokebir Cyclam
Cycloblastin Cycloblastine Cyclo Cell Cycloferon Cyclomide Cyclophar Cyclophospham Cyclophosphamid
cyclophosphamide monohydrate Cyclophosphamid Farmos Cyclophosphan Cyclophosphan Lens Cyclostin Cycloxan Cycram Cydoxan
Cyklofosfamid Cytophosphan Cytoxan Cytoxan Lyophilized Endoxan Endoxan-N Endoxana Endoxan Asta
Formitex Genoxal Genuxal Hidrofosmin Ledoxan Ledoxina Lyophilized Cytoxan Neosar
Oncomide Oncophos Procytox Revimmune Sendoxan Syklofosfamid Trav Cyclophosphamide Tymtran
Zycram

References

  1. ↑ 1.0 1.1 Cyclophosphamide (Cytoxan) package insert
  2. ↑ Cyclophosphamide (Cytoxan) package insert (locally hosted backup)
  3. ↑ Cyclophosphamide (Cytoxan) patient drug information (Chemocare)
  4. ↑ Cyclophosphamide (Cytoxan) patient drug information (UpToDate)
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