Difference between revisions of "Cisplatin (Platinol)"

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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>
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==Diseases for which it is used==
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*[[Aggressive Non-Hodgkin lymphoma]]
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*[[Anal cancer]]
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*[[Basal cell and squamous cell skin cancer]]
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*[[Bladder cancer]]
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*[[Bone cancer]]
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*[[Breast cancer]]
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*[[Central nervous system (CNS) cancer]]
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*[[Cervical cancer]]
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*[[Esophageal cancer]]
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*[[Gastric cancer]]
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*[[Head and neck cancer]]
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*[[Hepatobiliary cancer]]
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*[[Hodgkin lymphoma]]
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*[[Mantle cell lymphoma]]
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*[[Melanoma]]
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*[[Mesothelioma]]
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*[[Multiple myeloma]]
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*[[Neuroendocrine tumors]]
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*[[Non-small cell lung cancer]]
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*[[Ovarian cancer]]
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*[[Pancreatic cancer]]
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*[[Penile cancer]]
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*[[Small cell lung cancer]]
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*[[T-cell lymphoma]]
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*[[Testicular cancer]]
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*[[Thymoma]]
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*[[Unknown primary]]
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*[[Uterine cancer]]
  
 
==Patient drug information==
 
==Patient drug information==
 
*[http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx Cisplatin (Platinol) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx Cisplatin (Platinol) patient drug information (Chemocare)]</ref>
 
*[http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx Cisplatin (Platinol) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/cisplatin.aspx Cisplatin (Platinol) patient drug information (Chemocare)]</ref>
 
*[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]</ref>
 
*[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cisplatin-patient-drug-information Cisplatin (Platinol) patient drug information (UpToDate)]</ref>
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==History of changes in FDA indication==
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* 12/19/1978: Initial FDA approval
  
 
==Also known as==
 
==Also known as==
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[[Category:Thymoma medications]]
 
[[Category:Thymoma medications]]
 
[[Category:Uterine cancer medications]]
 
[[Category:Uterine cancer medications]]
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[[Category:Drugs FDA approved in 1978]]

Revision as of 15:30, 7 November 2014

General information

Class/mechanism: Platinum analog, alkylating-like, producing predominantly interstrand DNA crosslinks that are cell-cycle nonspecific.[1][2]
Route: IV
Extravasation: vesicant (concentration ≥0.5 mg/mL)/irritant (concentration <0.5 mg/mL)

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

  • 12/19/1978: Initial FDA approval

Also known as

Synonyms
Abiplatin Axiplat Biocisplatinum Bioplatino Blastolem Blastolem RU Briplatin Brisplatin
C-Platin CDDP Ceplatin Ciplatan Ciplexal cis-diamminedichloroplatinum III CIS-GRY cis-platinum
Cismaplat Cispatin Cisplamerck Cisplan Cisplasol Cisplatex Cisplatin-AQ Cisplatin-Ebewe I.A.
Cisplatin-Teva Cisplatin Comp Cisplatin DBL Cisplatine Cisplatin Ebewe Cisplatine Cytosafe Cisplatine Dakota Cisplatine Merck
Cisplatine Teva Cisplatin FOT Cisplatin Hexal Cisplatin Lederle Cisplatin Lens Cisplatin Maruko Cisplatin Mayne Cisplatin NC
Cisplatino Cisplatino Almirall Cisplatino Asofarm Cisplatino Deltafarma Cisplatino Ferrer Cisplatino Gador Cisplatino Labinca Cisplatino Martian
Cisplatino Microsules Cisplatino Pharmacia Cisplatino Teva Cisplatin Pharmachemie Cisplatin Pharmacia Cisplatin Sandoz Cisplatin Sanofi-Synthelabo Cisplatin Solution
Cisplatinum Cisplatyl Cisteen Citoplatino Cytoplatin Cytoplatin-AQ DACP DDP
Docistin Elvecis Fauldcispla IA COR Ifapla JIN Shun Kemoplat Lederplatin
Lyoph.cisplatin Metaplatin Neoplat Neoplatin Nippon Kayaku Cisplatin Noveldexis NSC 119875 NUO XIN
Oncoplatin AQ P&U Cisplatin Placis Platamin Platamine Platamine RTU Platiblastin Platiblastin-S
Platicis Platidiam Platikem Platil Platimit Platin Platinil Platino II Filaxis
Platinol Platinol AQ Platinox Platinoxan platinum Platiran Platistil Platistin
Platistine Platosin Pronto Platamine Randa Romcis Shun KE DA Sicatem Sinplatin
Sisplanil Tecnoplatin Tisplal Trav Cisplatin Unistin

References

  1. ↑ 1.0 1.1 Cisplatin (Platinol) package insert
  2. ↑ Cisplatin (Platinol) package insert (locally hosted backup)
  3. ↑ Cisplatin (Platinol) patient drug information (Chemocare)
  4. ↑ Cisplatin (Platinol) patient drug information (UpToDate)
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