Difference between revisions of "Anal cancer"
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{{#subobject:88896f |Variant=1}} | {{#subobject:88896f |Variant=1}} | ||
{{:Fluorouracil & cisplatin for anal cancer}} | {{:Fluorouracil & cisplatin for anal cancer}} | ||
| + | |||
| + | ==mDCF {{#subobject:70e20f|Regimen=1}}== | ||
| + | {| class="wikitable" style="float:right; margin-left: 5px;" | ||
| + | |- | ||
| + | |[[#top|back to top]] | ||
| + | |} | ||
| + | mDCF: '''<u>m</u>'''odified '''<u>D</u>'''ocetaxel, '''<u>C</u>'''isplatin, '''<u>F</u>'''luorouracil | ||
| + | ===Regimen {{#subobject:323b13|Variant=1}}=== | ||
| + | {| class="wikitable" style="width: 100%; text-align:center;" | ||
| + | !style="width: 50%"|Study | ||
| + | !style="width: 50%"|[[Levels_of_Evidence#Evidence|Evidence]] | ||
| + | |- | ||
| + | |[https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30321-8/fulltext Kim et al. 2018 (Epitopes-HPV02)] | ||
| + | | style="background-color:#91cf61" |Phase II | ||
| + | |- | ||
| + | |} | ||
| + | ====Chemotherapy==== | ||
| + | *[[Docetaxel (Taxotere)]] 40 mg/m<sup>2</sup> IV once on day 1 | ||
| + | *[[Cisplatin (Platinol)]] 40 mg/m<sup>2</sup> IV once on day 1 | ||
| + | *[[Fluorouracil (5-FU)]] 1200 mg/m<sup>2</sup>/day IV continuous infusion over 48 hours, started on day 1 (total dose per cycle: 2400 mg/m<sup>2</sup>) | ||
| + | |||
| + | '''14-day cycle for 8 cycles''' | ||
| + | |||
| + | ===References=== | ||
| + | # '''Epitopes-HPV02:''' Kim S, François E, André T, Samalin E, Jary M, El Hajbi F, Baba-Hamed N, Pernot S, Kaminsky MC, Bouché O, Desrame J, Zoubir M, Ghiringhelli F, Parzy A, De La Fouchardiere C, Smith D, Deberne M, Spehner L, Badet N, Adotevi O, Anota A, Meurisse A, Vernerey D, Taieb J, Vendrely V, Buecher B, Borg C. Docetaxel, cisplatin, and fluorouracil chemotherapy for metastatic or unresectable locally recurrent anal squamous cell carcinoma (Epitopes-HPV02): a multicentre, single-arm, phase 2 study. Lancet Oncol. 2018 Aug;19(8):1094-1106. Epub 2018 Jul 2. [https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(18)30321-8/fulltext link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/30042063 PubMed] | ||
[[Category:Anal cancer regimens]] | [[Category:Anal cancer regimens]] | ||
[[Category:Disease-specific pages]] | [[Category:Disease-specific pages]] | ||
[[Category:Gastrointestinal cancers]] | [[Category:Gastrointestinal cancers]] | ||
Revision as of 03:09, 6 January 2019
| Page editor | Section editor | ||
|---|---|---|---|
| coming soon | Ari Seifter, MD University of Illinois at Chicago Chicago, IL |
 |
Neeta K. Venepalli, MD, MBA University of Illinois at Chicago Chicago, IL |
9 regimens on this page
13 variants on this page
|
Guidelines
ESMO
- Anal cancer: ESMO-ESSO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up PubMed
NCCN
Definitive chemoradiotherapy for locally advanced disease
Capecitabine, Mitomycin, RT
| back to top |
Regimen
| Study | Evidence |
|---|---|
| Glynne-Jones et al. 2008 | Phase II |
Chemoradiotherapy
- Capecitabine (Xeloda) 825 mg/m2 PO BID on radiation days
- Mitomycin (Mutamycin) 12 mg/m2 IV once on day 1
- Concurrent radiation therapy: 1.8 Gy per day x 28 fractions (total dose: 50.4 Gy)
6-week course
References
- EXTRA: Glynne-Jones R, Meadows H, Wan S, Gollins S, Leslie M, Levine E, McDonald AC, Myint S, Samuel L, Sebag-Montefiore D; National Cancer Research Institute Anal Sub Group and Colorectal Clinical Oncology Group. EXTRA--a multicenter phase II study of chemoradiation using a 5 day per week oral regimen of capecitabine and intravenous mitomycin C in anal cancer. Int J Radiat Oncol Biol Phys. 2008 Sep 1;72(1):119-26. Epub 2008 May 9. link to original article contains protocol PubMed
Cisplatin, Fluorouracil, RT
Fluorouracil, cisplatin, radiation therapy for anal cancer
Fluorouracil, Mitomycin, RT
Fluorouracil, mitomycin, radiation therapy for anal cancer
Radiation therapy
Radiation therapy for anal cancer
Chemotherapy for metastatic disease
Cisplatin & Fluorouracil
Fluorouracil & cisplatin for anal cancer
mDCF
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mDCF: modified Docetaxel, Cisplatin, Fluorouracil
Regimen
| Study | Evidence |
|---|---|
| Kim et al. 2018 (Epitopes-HPV02) | Phase II |
Chemotherapy
- Docetaxel (Taxotere) 40 mg/m2 IV once on day 1
- Cisplatin (Platinol) 40 mg/m2 IV once on day 1
- Fluorouracil (5-FU) 1200 mg/m2/day IV continuous infusion over 48 hours, started on day 1 (total dose per cycle: 2400 mg/m2)
14-day cycle for 8 cycles
References
- Epitopes-HPV02: Kim S, François E, André T, Samalin E, Jary M, El Hajbi F, Baba-Hamed N, Pernot S, Kaminsky MC, Bouché O, Desrame J, Zoubir M, Ghiringhelli F, Parzy A, De La Fouchardiere C, Smith D, Deberne M, Spehner L, Badet N, Adotevi O, Anota A, Meurisse A, Vernerey D, Taieb J, Vendrely V, Buecher B, Borg C. Docetaxel, cisplatin, and fluorouracil chemotherapy for metastatic or unresectable locally recurrent anal squamous cell carcinoma (Epitopes-HPV02): a multicentre, single-arm, phase 2 study. Lancet Oncol. 2018 Aug;19(8):1094-1106. Epub 2018 Jul 2. link to original article PubMed